Narcolepsy (DBCOND0017525)

Identifiers

Synonyms
Narcolepsy without cataplexy / Narcolepsy (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amphetamine
A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
Armodafinil
A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder.
Dextroamphetamine
A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Ephedrine
An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
Metamfetamine
A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
Methylphenidate
A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
Modafinil
A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
Pitolisant
An antagonist and inverse agonist at the histamine H3 receptor that is used to treat narcolepsy in adults.
Sodium oxybate
A central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
Solriamfetol
Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05869773
A Switch Study From High-Sodium Oxybate to XYWAV to Evaluate Changes in Blood Pressure in Participants With Narcolepsytreatment4recruiting
NCT06179407
Study of MK-6552 in Participants With Narcolepsy Type 1 (MK-6552-004)No drug interventionstreatment1recruiting
NCT06586138
Study of Psychological, Sociological and Professional Factors Associated With Maintenance of Wakefulness TestNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04647903
Study to Evaluate the Abuse Liability, Pharmacokinetics, Safety and Tolerability of an Abuse-Deterrent d-Amphetamine Sulfate Immediate Release Formulation (ADAIR)treatment1completed
NCT03267303
A Study to Evaluate the Safety and Efficacy of TS-091 in Patients With NarcolepsyNo drug interventionstreatment2completed
NCT00049803
Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patientstreatment3completed
NCT00001664
Sleep Disorders of Patients With Diseases of the Nervous SystemNo drug interventionsNot AvailableNot Availablecompleted
NCT05615584
Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With HypersomnolenceNo drug interventionsdiagnosticNot Availablerecruiting
NCT03748979
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Participants With Narcolepsytreatment1completed
NCT03378453
Narcolepsy Protect Against Alzheimer's Disease?No drug interventionsotherNot Availablecompleted
NCT00228553
Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepinesstreatment3completed
NCT04899947
Child and Adolescent Registry for Participants With NarcolepsyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06279247
Proteomics and Metabolomics of Body Fluid in Patients With NarcolepsyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01789398
Patient Narcoleptic Treated With BF2.649 (Pitolisant) in add-on to Sodium Oxybate (HARMONY IV)treatment3completed
NCT01792583
The Nuvigil and Provigil Pregnancy RegistryNot AvailableNot Availableterminated
NCT02785328
Sleep and Memory in ChildrenNo drug interventionsbasic_scienceNot Availablecompleted
NCT02348593
"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Narcolepsy"treatment3completed
NCT03173378
Evaluation of Academic and Professional Trajectories of Narcoleptic PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01719315
Neurophysiologic Correlates of HypersomniaNo drug interventionsNot AvailableNot Availablecompleted
NCT03881852
Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)treatment2completed
NCT01146600
Clarithromycin for the Treatment of Hypersomniatreatment2completed
NCT00066170
Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsytreatment3completed
NCT04940806
The Value of Combined Detection of Orexin-A, HLA Gene, PSG and MSLT in the Evaluation of Patients With NarcolepsyNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01399606
Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant)treatment3completed
NCT02799849
Metabolism Characteristics in the Children With NarcolepsyNo drug interventionsbasic_scienceNot Availableunknown_status
NCT02077036
Narcolepsy - New Potential TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT05008341
Evaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral Administrationtreatment1completed
NCT00107796
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsytreatment3completed
NCT04330963
International Swiss Primary Hypersomnolence and Narcolepsy Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04803786
A Patient-Centric, Prospective, Observational, Non-Interventional Switch Study of XYWAV in NarcolepsyNot AvailableNot Availablecompleted
NCT04316286
TElemedicine for NARcolepsyNo drug interventionssupportive_careNot Availablecompleted
NCT00484757
Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and NeurocognitionNo drug interventionsbasic_scienceNot Availableunknown_status
NCT00174174
Provigil (Modafinil) Study by Taiwan Biotech Co.treatmentNot Availablecompleted
NCT00132873
Trial of Xyrem® (Sodium Oxybate) for the Treatment of NarcolepsyNot Available3completed
NCT03626727
Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomniatreatment0withdrawn
NCT04923594
Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsytreatment2completed
NCT04141891
Advancing Understanding of Transportation OptionsNo drug interventionshealth_services_researchNot Availablecompleted
NCT01624480
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsytreatment1completed
NCT02769780
A Web-based Observational Study of Patient-reported Outcomes in Adults With NarcolepsyNo drug interventionsNot AvailableNot Availablecompleted
NCT04072380
A Study to Evaluate Safety, and Efficacy of SUVN-G3031 (Samelisant) in Patients With Narcolepsy With and Without Cataplexytreatment2completed
NCT03765892
Study of the Academic and Professional Course of Narcoleptic Patients (NARCOSCOL-NARCOVITAE)No drug interventionsNot AvailableNot Availablecompleted
NCT04419792
'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy'No drug interventionsNot AvailableNot Availablesuspended
NCT05773872
Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic HypersomniaNo drug interventionsscreeningNot Availablerecruiting
NCT04451668
An Open Label Study of FT218 in Subjects With NarcolepsyNo drug interventionstreatment3completed
NCT00214968
Assess the Safety and Effectiveness of PROVIGIL Treatment in Children and Adolescents With Excessive Sleepinesstreatment3completed
NCT00078312
Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disordertreatment3completed
NCT05884112
Treating Comorbid Depression of Patients With Narcolepsy by Intermittent Theta Burst StimulationNo drug interventionstreatmentNot Availablerecruiting
NCT05321355
Mainz Register of Patients With Sleep DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT05059223
A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsytreatment3completed
NCT04667338
A Study to Collect Information of People With Narcolepsy in SpainNo drug interventionsNot AvailableNot Availablecompleted
NCT01681121
A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With NarcolepsyNo drug interventionstreatment2completed
NCT05373979
Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes ScaleNo drug interventionsNot AvailableNot Availableunknown_status
NCT02913651
Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic HypersomniaNo drug interventionsNot AvailableNot Availablecompleted
NCT00916253
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness PathologiesdiagnosticNot Availablecompleted
NCT00078377
Safety and Efficacy Study of Armodafinil (CEP-10953) in the Treatment of Excessive Sleepiness Associated With Narcolepsytreatment3completed
NCT05530447
Expanded Access to SUVN-G3031 (Samelisant) for the Treatment of Subjects With NarcolepsyNot AvailableNot Availableno_longer_available
NCT05113745
A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsytreatment3enrolling_by_invitation
NCT05371483
Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their TreatmentsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05536011
WAKIX® (Pitolisant) Pregnancy RegistryNot AvailableNot Availablerecruiting
NCT05627388
Feasibility Study of At-Home EEG Monitoring for HypersomniaNo drug interventionsotherNot Availablewithdrawn
NCT02821715
Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patientstreatment2completed
NCT02348632
"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"treatment3completed
NCT04306952
Awareness and Self-Compassion Enhancing Narcolepsy TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT01485770
A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime SleepinessNo drug interventionstreatment2completed
NCT06383806
Decreasing Nightmares in Adults With NarcolepsyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02832336
The Effect of Caffeine on the Narcoleptic Patientssupportive_care1 / 2completed
NCT05055024
An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With Narcolepsytreatment2completed
NCT05870735
Discovering Factors in Narcolepsy Patients' Clinical Research ExperiencesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01067235
Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespytreatment3completed
NCT01067222
Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsytreatment3completed
NCT01006122
A Study Of A Novel Compound For Excessive Daytime Sleepiness Associated With Narcolepsytreatment2completed
NCT00107848
PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrometreatment3completed
NCT00228566
Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrometreatment3completed
NCT00244465
Observational Study to Evaluate Risks of Side Effects, Drug Abuse and Dependence in Patients Who Received Xyrem ® on PrescriptionNo drug interventionsNot AvailableNot Availablecompleted
NCT05875974
A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsytreatment4recruiting
NCT06413420
SUNOSI® (Solriamfetol) Pregnancy RegistryNot AvailableNot Availablerecruiting
NCT00424931
A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsytreatment2completed
NCT05015673
This is a Study to Determine the Effect of Multiple Doses of an Investigational Drug, Taken by Mouth, in People With Narcolepsy-cataplexy. Accepting Both Males and Females Ages of 18 Years to 55 Years. This Study Will be Conducted in the US and Will Require Approximately 13 Weeks Participation.treatment1completed
NCT05709873
Narcolepsy Nightmare StudyNo drug interventionstreatmentNot Availablecompleted
NCT00283894
Body Weight Regulation in Patients With NarcolepsyNo drug interventionsNot AvailableNot Availablecompleted
NCT04794491
An Interventional Safety Switch Study (Segue Study) of XYWAV in Narcolepsytreatment4completed
NCT00366080
Effectiveness Of The Drug GSK189254 In Treating Patients With NarcolepsyNo drug interventionstreatment2terminated
NCT04827329
Anesthetic Management of Patients With Chronic Sleep DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT02720744
Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsytreatment3completed
NCT04232644
Pilot Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Abuse Liability of an Abuse-Deterrent Immediate-Release Formulation (ADAIR)treatment1completed
NCT03376568
Investigation of Clinical Feature and Brain Function in Narcoleptic PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01394614
Risk of Narcolepsy Associated With Administration of H1N1 VaccineNo drug interventionsNot AvailableNot Availablecompleted
NCT03425214
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior DisorderNo drug interventionsdiagnosticNot Availableunknown_status
NCT02806908
Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsytreatment2completed
NCT03904238
Psychosocial Adjunctive Treatment for Hypersomnia (PATH)No drug interventionstreatmentNot Availablecompleted