Nasal Decongestants

Name
Nasal Decongestants
Accession Number
DBCAT000818
Description

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)

Drugs
DrugDrug Description
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
XylometazolineA direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations.
CirazolineCirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. It is believed...
SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
Drugs & Drug Targets
DrugTargetType
PhenylephrineAlpha-1A adrenergic receptortarget
PhenylephrineAlpha-1B adrenergic receptortarget
PhenylephrineAmine oxidase [flavin-containing] Aenzyme
PhenylephrineAlpha-1D adrenergic receptortarget
PhenylephrineCytochrome P450 1A2enzyme
PhenylephrineSulfotransferase 1A3/1A4enzyme
PhenylephrineAmine oxidase [flavin-containing] Benzyme
PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
PhenylpropanolamineDopamine D1 receptortarget
PhenylpropanolamineBeta-1 adrenergic receptortarget
PhenylpropanolamineBeta-2 adrenergic receptortarget
PhenylpropanolamineAlpha-2 adrenergic receptorstarget
PseudoephedrineAlpha-1A adrenergic receptortarget
PseudoephedrineAlpha-2A adrenergic receptortarget
PseudoephedrineBeta-2 adrenergic receptortarget
PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
PseudoephedrineBeta-1 adrenergic receptortarget
PseudoephedrineSodium-dependent dopamine transportertarget
PseudoephedrineSodium-dependent noradrenaline transportertarget
PseudoephedrineSodium-dependent serotonin transportertarget
PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
PseudoephedrineTumor necrosis factortarget
PseudoephedrineNuclear factor NF-kappa-B p105 subunittarget
Pseudoephedrineactivator protein 1target
PseudoephedrineInterleukin-2target
PseudoephedrineSerum albumincarrier
PseudoephedrineSodium-dependent noradrenaline transportertransporter
PseudoephedrineSodium-dependent dopamine transportertransporter
PseudoephedrineSodium-dependent serotonin transportertransporter
OxymetazolineAlpha-1A adrenergic receptortarget
OxymetazolineAlpha-2A adrenergic receptortarget
OxymetazolineAlpha-2C adrenergic receptortarget
OxymetazolineAlpha-2B adrenergic receptortarget
OxymetazolineAlpha-1B adrenergic receptortarget
OxymetazolineAlpha-1D adrenergic receptortarget
Oxymetazoline5-hydroxytryptamine receptor 1Atarget
Oxymetazoline5-hydroxytryptamine receptor 1Btarget
Oxymetazoline5-hydroxytryptamine receptor 1Dtarget
Oxymetazoline5-hydroxytryptamine receptor 1Ctarget
OxymetazolineUDP-glucuronosyltransferase 1-9enzyme
OxymetazolineCytochrome P450 2C19enzyme
XylometazolineAlpha-2A adrenergic receptortarget
XylometazolineAlpha-1A adrenergic receptortarget
XylometazolineAlpha-1B adrenergic receptortarget
XylometazolineAlpha-1D adrenergic receptortarget
XylometazolineAlpha-2B adrenergic receptortarget
XylometazolineAlpha-2C adrenergic receptortarget
NaphazolineAlpha-1A adrenergic receptortarget
NaphazolineAlpha-2A adrenergic receptortarget
TetryzolineAlpha-1A adrenergic receptortarget
CirazolineAlpha-1A adrenergic receptortarget
CirazolineAlpha-1B adrenergic receptortarget
CirazolineAlpha-1D adrenergic receptortarget
CirazolineAlpha-2 adrenergic receptorstarget
SynephrineAlpha-1 adrenergic receptorstarget