Vitamin supplementation (DBCOND0025906)

Identifiers

Synonyms

Vitamin supplement therapy (regime/therapy) / Medicinal product acting as vitamin supplement (product)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ascorbic acid	A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.	Prolyl 4-hydroxylase subunit alpha-1target Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1target Hyaluronate lyasetarget DNAtarget Xylose isomerasetarget Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2target Phytanoyl-CoA dioxygenase, peroxisomaltarget Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3target Gamma-butyrobetaine dioxygenasetarget Dopamine beta-hydroxylasetarget Peptidyl-glycine alpha-amidating monooxygenasetarget Prolyl 3-hydroxylase 1target 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target DNA oxidative demethylase ALKBH2target Prolyl 3-hydroxylase 2target Prolyl 3-hydroxylase 3target Prolyl 3-hydroxylase OGFOD1target Prolyl hydroxylase EGLN2target Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3target Lysine-specific demethylase 5Dtarget Egl nine homolog 1target Prolyl hydroxylase EGLN3target Trimethyllysine dioxygenase, mitochondrialtarget Transmembrane prolyl 4-hydroxylasetarget Solute carrier family 23 member 1transporter Solute carrier family 23 member 2transporter Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Albumincarrier Thioredoxin reductase 1, cytoplasmicenzyme Solute carrier family 23 member 2target Solute carrier family 23 member 1target
Cholecalciferol	A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.	Vitamin D-binding proteincarrier Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Vitamin D 25-hydroxylaseenzyme Sterol 26-hydroxylase, mitochondrialenzyme Cytochrome P450 2J2enzyme Cytochrome P450 3A4enzyme Vitamin D3 receptortarget Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme
Citrus bioflavonoids	Not Annotated	No drug targets
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Hemoporfin	A porphyrin derivative combined with vitamin B12 for the treatment of asthenia.	No drug targets
Lutein	Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.	Albumincarrier
Manganese cation	A transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).	Cytoplasmic aconitate hydrataseenzyme Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget TGF-beta-activated kinase 1 and MAP3K7-binding protein 1target Arginase-1target Serotransferrincarrier Albumincarrier Metal cation symporter ZIP14transporter Superoxide dismutase [Mn], mitochondrialtarget Glutamine synthetasetarget Phosphoenolpyruvate Carboxykinasestarget Natural resistance-associated macrophage protein 2transporter Calcium/manganese antiporter SLC30A10transporter Ceruloplasmincarrier Transient receptor potential cation channel subfamily M member 7transporter Serine/threonine-protein phosphatase PP1-gamma catalytic subunittarget
NADH	A nutrient used in some supplement products.	UDP-glucose 6-dehydrogenasetarget Alcohol dehydrogenase 1Atarget Sorbitol dehydrogenasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH4target Alcohol dehydrogenase 1Ctarget All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget L-lactate dehydrogenase A-like 6Atarget Alcohol dehydrogenase class-3target Aldo-keto reductase family 1 member B1target 3-hydroxyacyl-CoA dehydrogenase type-2target Malate dehydrogenase, mitochondrialtarget L-lactate dehydrogenase A chaintarget NAD-dependent malic enzyme, mitochondrialtarget Peroxisomal multifunctional enzyme type 2target L-lactate dehydrogenase A-like 6Btarget L-lactate dehydrogenase C chaintarget L-lactate dehydrogenase B chaintarget Peroxisomal bifunctional enzymetarget Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialtarget NADP-dependent malic enzyme, mitochondrialtarget D-beta-hydroxybutyrate dehydrogenase, mitochondrialtarget Malate dehydrogenase, cytoplasmictarget 3-hydroxyisobutyrate dehydrogenase, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 3target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget NADP-dependent malic enzymetarget D-3-phosphoglycerate dehydrogenasetarget 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7target Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 1target 17-beta-hydroxysteroid dehydrogenase type 2target Retinol dehydrogenase 5target GDH/6PGL endoplasmic bifunctional proteintarget (3R)-3-hydroxyacyl-CoA dehydrogenasetarget Aldo-keto reductase family 1 member C4target Inosine-5'-monophosphate dehydrogenase 2target Aldo-keto reductase family 1 member C3target 15-hydroxyprostaglandin dehydrogenase [NAD(+)]target GDP-L-fucose synthasetarget Aldo-keto reductase family 1 member C1target 11-beta-hydroxysteroid dehydrogenase 1target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Inosine-5'-monophosphate dehydrogenase 1target Trifunctional enzyme subunit alpha, mitochondrialtarget Aldehyde dehydrogenase, mitochondrialtarget 11-beta-hydroxysteroid dehydrogenase type 2target Aldo-keto reductase family 1 member C2target Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingtarget Aldehyde dehydrogenase family 3 member B2target Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrialtarget Aldehyde dehydrogenase, dimeric NADP-preferringtarget Aldehyde dehydrogenase 1A1target Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget 4-trimethylaminobutyraldehyde dehydrogenasetarget Retinaldehyde dehydrogenase 3target Aldehyde dehydrogenase X, mitochondrialtarget Aldehyde dehydrogenase family 3 member B1target Glyceraldehyde-3-phosphate dehydrogenasetarget Retinal dehydrogenase 2target Aldehyde dehydrogenase family 3 member A2target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Alpha-aminoadipic semialdehyde dehydrogenasetarget Flavin reductase (NADPH)target Pyrroline-5-carboxylate reductase 2target Pyrroline-5-carboxylate reductase 1, mitochondrialtarget Glutamate dehydrogenase 1, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit beta, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialtarget Biliverdin reductase Atarget Short-chain specific acyl-CoA dehydrogenase, mitochondrialtarget Dihydrofolate reductasetarget 2-oxoglutarate dehydrogenase complex component E1target Glutamate dehydrogenase 2, mitochondrialtarget 7-dehydrocholesterol reductasetarget Ribosyldihydronicotinamide dehydrogenase [quinone]target NADH-ubiquinone oxidoreductase chain 2target Alpha-aminoadipic semialdehyde synthase, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 3target NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialtarget C-1-tetrahydrofolate synthase, cytoplasmictarget Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialtarget NADH-cytochrome b5 reductase 3target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11target NADH-ubiquinone oxidoreductase chain 4target Dihydropteridine reductasetarget NADH-ubiquinone oxidoreductase chain 1target NAD(P) transhydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 4Ltarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1target NADH-ubiquinone oxidoreductase chain 6target NADH-ubiquinone oxidoreductase chain 5target Cytochrome c oxidase subunit NDUFA4target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6target Acyl carrier protein, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C2target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1target NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9target NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6target NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget Dihydrolipoyl dehydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialtarget Glutathione reductase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12target NADH dehydrogenase [ubiquinone] iron-sulfur protein 5target NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13target Cysteine dioxygenase type 1target NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2target NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialtarget Cytochrome P450 4A11target Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget Aminomethyltransferase, mitochondrialtarget Methylsterol monooxygenase 1target Heme oxygenase 1target Heme oxygenase 2target Steroid 17-alpha-hydroxylase/17,20 lyasetarget Tyrosinasetarget Xanthine dehydrogenase/oxidaseenzyme Aldehyde oxidaseenzyme Alcohol dehydrogenase 6enzyme Aldo-keto reductase family 1 member A1enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Alcohol dehydrogenase class-3enzyme All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme
Phylloquinone	A fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.	Vitamin K-dependent gamma-carboxylasetarget Osteocalcintarget Cytochrome P450 4F2enzyme UbiA prenyltransferase domain-containing protein 1enzyme Vitamin K epoxide reductase complex subunit 1enzyme
Pyridoxal phosphate	A vitamin available in many formulations to correct vitamin B6 deficiency.	Cystathionine beta-synthasetarget Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Glutamate decarboxylase 1target Kynureninasetarget Serine hydroxymethyltransferase, cytosolictarget Cysteine desulfurasetarget Aspartate aminotransferase, cytoplasmictarget Ornithine aminotransferase, mitochondrialtarget Ornithine decarboxylasetarget Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget 4-aminobutyrate aminotransferase, mitochondrialtarget Pyridoxine-5'-phosphate oxidasetarget Sphingosine-1-phosphate lyase 1target Tyrosine aminotransferasetarget Kynurenine--oxoglutarate transaminase 1target Glycogen phosphorylase, liver formtarget Serine palmitoyltransferase 2target Cysteine sulfinic acid decarboxylasetarget Histidine decarboxylasetarget Antizyme inhibitor 2target L-serine dehydratase/L-threonine deaminasetarget 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget Glycine dehydrogenase (decarboxylating), mitochondrialtarget Alanine aminotransferase 1target Phosphoserine aminotransferasetarget 5-aminolevulinate synthase, non-specific, mitochondrialtarget Alanine--glyoxylate aminotransferasetarget Chronophintarget Serine palmitoyltransferase 1target Cystathionine gamma-lyasetarget Branched-chain-amino-acid aminotransferase, cytosolictarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Pyridoxal phosphate homeostasis proteintarget Aspartate aminotransferase, mitochondrialtarget Glycogen phosphorylase, brain formtarget Glycogen phosphorylase, muscle formtarget Aromatic-L-amino-acid decarboxylasetarget Serine hydroxymethyltransferasetarget Glutamate decarboxylase 2target Kynurenine--oxoglutarate transaminase 3target Acidic amino acid decarboxylase GADL1target Selenocysteine lyasetarget Immunoglobulin superfamily member 10target 5-phosphohydroxy-L-lysine phospho-lyasetarget Serine hydroxymethyltransferase, mitochondrialtarget 5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget Alanine aminotransferase 2target Molybdenum cofactor sulfurasetarget Serine dehydratase-liketarget Serine racemasetarget O-phosphoseryl-tRNA(Sec) selenium transferasetarget Serine palmitoyltransferase 3target Glutamic acid decarboxylasetarget Aspartate aminotransferasetarget Prothrombintarget
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget
Riboflavin	A vitamin used to correct vitamin B2 deficiency.	Flavin reductase (NADPH)target Riboflavin kinasetarget Riboflavin synthasetarget Amine oxidase [flavin-containing] Aenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Solute carrier family 22 member 6transporter
Rutin	A flavonoid found in over-the-counter vitamin supplements.	Aldo-keto reductase family 1 member C3target Cytochrome P450 3A4enzyme Carbonyl reductase [NADPH] 1target
Selenic acid	An ingredient found in a variety of supplements and vitamins.	No drug targets
Sodium ascorbate	Not Available	No drug targets
Thiamine	A vitamin used to correct vitamin B1 deficiency.	Thiamine pyrophosphokinase 1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter Cytochrome P450 4B1enzyme Thiamine transporter 1transporter Thiamine transporter 2transporter Thiamine pyrophosphokinase 1enzyme Nucleoside diphosphate phosphatase ENTPD5enzyme Thiamine-triphosphataseenzyme Albumincarrier Pyruvate dehydrogenase E1 componenttarget
Zeaxanthin	Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some...	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04136119	Micronutrients in Critically Ill Patients	No drug interventions	Not Available	Not Available	completed