Estrogen Replacement Therapy (DBCOND0031964)

Identifiers

Synonyms

Estrogen replacement therapy / Oestrogen replacement therapy

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Conjugated estrogens	A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.	Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Catechol O-methyltransferaseenzyme ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 6transporter Organic solute transporter subunit alphatransporter Organic solute transporter subunit betatransporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 4A1transporter ATP-binding cassette sub-family C member 11transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 3A1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Thyroxine-binding globulincarrier Sex hormone-binding globulincarrier Albumincarrier Estrogen receptor betatarget
Estriol	A weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.	Estrogen receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Estrogen receptor betatarget Sex hormone-binding globulintarget
Medroxyprogesterone acetate	A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.	Progesterone receptortarget Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A1enzyme Albumincarrier ATP-dependent translocase ABCB1target GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00318318	Beneficial Effects of Oral Premarin Estrogen Replacement Therapy Assessed by Human Genome Array	Conjugated estrogens	diagnostic	1	completed
NCT00401219	Study Comparing Bioavailability of 3 New Formulations of Premarin/MPA With Premarin/MPA (PREMPRO) Reference Formulation	Conjugated estrogens Medroxyprogesterone acetate	treatment	1	completed
NCT06544473	Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome	Estradiol	treatment	4	recruiting
NCT06570460	Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome	Estradiol	treatment	4	recruiting
NCT00173550	Perception and Attitude Toward Estrogen Therapy Among Surgically Menopausal Women	No drug interventions	Not Available	Not Available	unknown_status
NCT05483634	Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause	Estradiol	Not Available	Not Available	not_yet_recruiting
NCT00883662	Mirena Observational Program	Levonorgestrel	Not Available	Not Available	completed
NCT04050592	Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life	Estradiol	basic_science	4	unknown_status