Neoplasms, Hematologic (DBCOND0056760)

Identifiers

Synonyms
Hematological Neoplasm / Hematological Neoplasms / Hematologic Neoplasm / Hematologic Neoplasms / Haematological neoplasm / Malignant tumor of lymphoid hemopoietic and related tissue (disorder) / Haematological malignancy / Hematological malignancy / Hematologic neoplasm (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Midostaurin
An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02976558
The Influence of TaKeTiNa Music Therapy, Traditional Chinese Acupuncture and Clown Theatrical Performance on Quality of Life and the Therapeutic Process of Patients Undergoing Allogenic Stem Cell TransplantationNo drug interventionstreatmentNot Availableterminated
NCT05502887
The Endothelial Cell Dysfunction and Outcome Project for Hematological NeoplasmsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02223052
Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignanciestreatment1completed
NCT00410696
Pegfilgrastim Versus Filgrastim After High-dose ChemotherapyNo drug interventionstreatment2completed
NCT02544230
Granulocyte Transfusions in Hematological Patients With Febrile NeutropeniaNo drug interventionsNot AvailableNot Availablecompleted
NCT00440765
VALEO: A Post Authorization Study, Designed to Learn More About the Safety and Effectiveness of the Use of Bortezomib in the NetherlandsNo drug interventionsNot AvailableNot Availablecompleted
NCT02634294
Peg Interferon α-2b for Relapsed Hematological Malignancies After Allo-HSCTtreatment2 / 3completed
NCT00440479
ADVANCE: An Observational Study To Determine Bortezomib Safety and Effectiveness at First Relapse After Participation In First Line HOVON-49/50 Clinical Studies.No drug interventionsNot AvailableNot Availablecompleted
NCT03844360
Dose Individualization of Antineoplastic Drugs and Anti-Infective Drug in Children With Hematoplastic DiseaseNo drug interventionstreatment4unknown_status
NCT00582894
Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Malignant Hematological DiseasesNo drug interventionstreatmentNot Availablecompleted
NCT01594723
A Study of LY2784544 in Participants With Myeloproliferative NeoplasmsNo drug interventionstreatment2active_not_recruiting
NCT00001432
The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic MalignanciesNo drug interventionsNot AvailableNot Availablecompleted
NCT02494258
A Study to Evaluate Long-term Safety of CC-486 (Oral Azacitidine) in Subjects With Hematological Disorderstreatment2active_not_recruiting
NCT00001873
The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood CancersNo drug interventionstreatment2completed
NCT00001872
Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00001623
Bone Marrow Transplant Studies for Safe and Effective Treatment of LeukemiaNo drug interventionstreatmentNot Availablecompleted
NCT01855698
PENELOPE Observational Study: Prophylaxis and Treatment of Arterial and Venous ThromboembolismNo drug interventionsNot AvailableNot Availablecompleted
NCT00005785
Stem Cell (Modified Bone Marrow) Transplantation in HIV-Infected Patients With Blood CancerNo drug interventionstreatment1completed
NCT02745743
Phase I Trial of BAY1251152 for Advanced Blood CancersNo drug interventionstreatment1completed
NCT02635984
Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy RegimensNo drug interventionssupportive_care3completed
NCT04448184
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial)No drug interventionsother3recruiting
NCT04760184
Impact of COVID-19 After Autologous Hematopoietic Stem Cell Transplantation in SwedenNo drug interventionsNot AvailableNot Availablecompleted
NCT01802879
Study to Allow Access to Single Agent Panobinostat for Patients Who Are on s.a. Panobinostat Treatment in a Novartis-sponsored Study and Continue to Benefit From the Treatment as Judged by the InvestigatorNo drug interventionstreatment2completed
NCT01362179
National Marrow Donor Program Long-Term Donor Follow-UpNo drug interventionsNot AvailableNot Availablecompleted
NCT06422533
Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological PatientstreatmentNot Availablerecruiting
NCT00473577
Study of the Tolerability, Safety, and Pharmacokinetics of CRA-024781 in Cancer PatientsNo drug interventionstreatment1completed
NCT02329847
A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Combination of Ibrutinib With Nivolumab in Participants With Hematologic Malignanciestreatment1 / 2completed
NCT02504047
Use of Haploidentical Related Donors for Patients Without Matched Sibling, Unrelated Donor or Cord Blood UnitsNo drug interventionstreatmentNot Availablecompleted
NCT05902845
RD13-02 CAR-T Cell Injection for Patients With r/r CD7+ T-ALL/T-LBLNo drug interventionstreatment0recruiting
NCT01915498
Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutationtreatment1 / 2completed
NCT04323605
Assistance Program for Outpatients Following an Allogeneic Hematopoietic Stem-cell TransplantNo drug interventionsotherNot Availableunknown_status
NCT01021683
The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised ParticipantsNot AvailableNot Availablecompleted
NCT02061761
A Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab in Relapsed or Refractory B-Cell Malignanciestreatment1 / 2completed
NCT00389428
Multicenter Study of CPX-351(Cytarabine:Daunorubicin) Liposome Injection in Patients With Advanced Hematologic Cancer.No drug interventionstreatment1completed
NCT02033928
Comprehensive Frailty AssessmentNo drug interventionsNot AvailableNot Availablecompleted
NCT03301493
Genomic Testing and Resulting Medical DecisionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02477878
Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplanttreatment1active_not_recruiting
NCT00698685
Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem Cell Transplantationtreatment2terminated
NCT03320915
Efficacy and Safety of High Dose Vitamin D Supplementation in Patients Undergoing HSCTtreatment2unknown_status
NCT05549232
Hypoxic Red Blood Cells for Burns and Hematological Malignancies at Haukeland University HospitalNo drug interventionsNot AvailableNot Availablerecruiting
NCT05882175
Prospective Validation of the OHI IndexNo drug interventionsNot AvailableNot Availablerecruiting
NCT01332006
Intra-bone Cord Blood TransplantationNo drug interventionstreatment2unknown_status
NCT01244906
Post-transplant Cyclophosphamide and Sirolimus Following Reduced Intensity Conditioning (RIC) TransplantNo drug interventionstreatment2completed
NCT06433349
A Multi-center Investigation of Family Health.No drug interventionsNot AvailableNot Availablerecruiting
NCT00421213
Phase II Study of ZIO-101 in Advanced Blood and Bone Marrow CancersNo drug interventionstreatment2completed
NCT00028418
Clofarabine in Chronic Lymphocytic LeukemiaNo drug interventionstreatment1completed
NCT01869218
Feasibility Study of Genomic Sequencing to Find Potential Targets for Personalized TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT01374841
Hematopoietic Cell Transplantation for Patients With Hematologic Malignancies Using Related, HLA-Haploidentical Donorstreatment2recruiting
NCT03288441
Management and Outcomes of Anti-thrombotic Medication Use in ThrombocytopeniaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02367196
A Phase 1, Dose Finding Study of CC-90002 in Subjects With Advanced Solid and Hematologic Cancerstreatment1completed
NCT00997386
Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure Statestreatment2completed
NCT00001748
HLA-Mismatched Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematological MalignanciesNo drug interventionstreatment1completed
NCT00750126
Allogeneic Hematopoietic Stem Cell Transplantationtreatment2unknown_status
NCT04871165
Analysis of Immunogenicity, Safety and Efficacy of COVID-19 Vaccines in Immunosuppressed IndividualsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05054231
Immunological Profile for Patients Treated With CAR-T CellsNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT00038376
Phase II Study Of Roferon and Accutane For Patients With T-Cell MalignanciesNo drug interventionstreatment2completed
NCT02650791
Platelet Transfusion Requirements in Hematopoietic Transplantation Pilot Studyother3completed
NCT04303091
The Feasibility of a Physical Activity Intervention for Advanced Multiple Myeloma PatientsNo drug interventionsotherNot Availablecompleted
NCT05819762
Evaluation of ClearLLab LS Screening PanelNo drug interventionsNot AvailableNot Availablerecruiting
NCT02958462
Pre-myeloid Cancer and Bone Marrow Failure Clinic StudyNo drug interventionsscreeningNot Availablerecruiting
NCT00957580
Trial of Pimasertib in Hematological Malignanciestreatment2terminated
NCT03743480
Early Palliative Care and Hematological Cancer PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT04310592
Natural Killer Cell (CYNK-001) Infusions in Adults With AMLNo drug interventionstreatment1recruiting
NCT03680092
Comparing Cyclophosphamide and Abatacept With Standard of Care Treatment Following Stem Cell TransplantationNo drug interventionstreatment2active_not_recruiting
NCT03575767
Characteristics and Dynamics of TCR Repertoire in Patients With Hematological Malignancies After Allo-HSCTNo drug interventionsNot AvailableNot Availablecompleted
NCT04264767
Characterization of Methylation Patterns in Cancer and Non-Cancer cfDNANo drug interventionsNot AvailableNot Availablecompleted
NCT03349372
Impact of Pulmonary Follow-up After Stem Cell GraftNo drug interventionsNot AvailableNot Availablecompleted
NCT03648372
A Study of TAK-981 in People With Advanced Solid Tumors or Cancers in the Immune SystemNo drug interventionstreatment1 / 2terminated
NCT01790568
Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell TransplantNo drug interventionsprevention2completed
NCT05061095
Understanding What Matters Most to Patients: Establishing the Validity of a Best-Worst Scaling SurveyNo drug interventionsNot AvailableNot Availablecompleted
NCT00900614
Safety Study of APR-246 in Patients With Refractory Hematologic Cancer or Prostate CancerNo drug interventionstreatment1completed
NCT03983850
Optimizing PTCy Dose and TimingNo drug interventionstreatment1 / 2recruiting
NCT05327023
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic MalignanciesNo drug interventionstreatment1 / 2recruiting
NCT05907603
Research Development(RD)13-02 Chimeric Antigen Receptor(CAR) -T Cell Injection for Patients With r/r Cluster Of Differentiation 7(CD7)+ T-Acute Lymphoblastic Leukemia(ALL)/T-Lymphoblastic Lymphoma(LBL) /Acute Myelogenous Leukemia(AML)No drug interventionstreatment0recruiting
NCT03023202
UWCCC Molecular Tumor Board RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT04691284
Microbiome in Cancer Patients With High Dose Chemotherapy With Stem Cell TransplantationNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00987987
Amplifying Graft-Versus-Tumor Effect by Donor Regulatory T-Cell Depletion Before Donor Lymphocytes InfusionNo drug interventionstreatment1 / 2completed
NCT04275154
Immunological Parameters, Neurocognitive Changes, Activity, & Driving Fitness in Patients Undergoing CAR-T Cell TherapyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT05602051
Mindfulness-based Virtual Reality InterventionNo drug interventionssupportive_careNot Availablerecruiting
NCT03136445
TRial to EvaluAte Tranexamic Acid Therapy in ThrombocytopeniaNo drug interventionssupportive_care3completed
NCT00071045
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family MembersNo drug interventionsNot AvailableNot Availablerecruiting
NCT00526045
Phase I-II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 in Advanced Solid Malignancies, and Efficacy in HER2+ or ER+ Locally Advanced or Metastatic Breast Cancer PatientsNo drug interventionstreatment1 / 2completed
NCT02944045
Effect of Steroids During Pneumocystis Infection Among Non HIV Immunocompromised PatientsNo drug interventionstreatment3unknown_status
NCT00051311
Modified Stem Cell Transplant Procedure to Treat Patients With Blood and Immune System CancersNo drug interventionstreatment2completed
NCT02623309
Studyof Allogeneic Hematopoietic Stem Cell Transplantation From One Haplotype Mismatch Related Donor or From an Unrelated Donor in Elderly PatientsNo drug interventionstreatment3completed
NCT05256537
Fludarabine and Total Body Irradiation 800 Centigray (cGy) or 1125 cGy For Allogeneic Stem Cell Transplant Using Graft Versus Host Disease Prophylaxis With Post-Transplant Cyclophosphamide and Tacrolimus, Without Mycophenolate MofetilNo drug interventionstreatment2active_not_recruiting
NCT00044759
Study Comparing the Safety and Efficacy of Piperacillin/Tazobactam to Cefepime in Patients With Hematologic Malignancy or LymphomaNo drug interventionstreatment3completed
NCT04959175
Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic MalignanciesNo drug interventionstreatment1 / 2recruiting
NCT03403075
Therapeutic Education in Physical Activity (ETAF)No drug interventionstreatmentNot Availablecompleted
NCT00623870
A Study of RO5045337 [RG7112] in Patients With Hematologic Neoplasms.No drug interventionstreatment1completed
NCT00914849
Intravenous (IV) AMD3100 for Mobilization and Matched Related Transplant for Advanced Hematological MalignanciesNo drug interventionstreatment2completed
NCT05716113
CD7 CAR-T for Patients With r/r CD7+ T-ALL/T-LBLNo drug interventionstreatment0recruiting
NCT06339541
The ACC Preclinical Research Platform for Precision OncologyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01275534
Symptom Experience and Self-management After Haematopoietic Stem Cell TransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT03505086
Bleeding In Thrombocytopenia ExplainedNo drug interventionsNot AvailableNot Availablerecruiting
NCT00595686
Safety And Pharmacology Of SNX-5422 Mesylate In Subjects With Refractory Hematological MalignanciesNo drug interventionstreatment1completed
NCT03722186
Safety, Tolerability and Pharmacokinetics/Pharmacodynamics (PK/PD) of SHR-1603 in Subjects With Advanced MalignanciesNo drug interventionstreatment1suspended
NCT00067730
A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow TransplantationNo drug interventionstreatment4completed
NCT02900248
CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician ChoiceNo drug interventionsNot AvailableNot Availableterminated
NCT03094026
Cognitive Training Intervention and Attitudes Towards GeneticsNo drug interventionssupportive_careNot Availablerecruiting
NCT05672420
Umbilical Cord Derived Mesenchymal Stem Cells for Treatment-induced Myelosuppression in Hematologic MalignanciesNo drug interventionstreatment1 / 2not_yet_recruiting
NCT03087227
Shared Health Information System for Febrile NeutropeniaNo drug interventionshealth_services_researchNot Availablecompleted
NCT03083327
Prophylactic Early PN in HPT/BMTNo drug interventionspreventionNot Availableunknown_status
NCT03483194
Therapeutic Virtual Reality : Impact on the Management of Pain and Anxiety Related to Hematology Care (REVEH)No drug interventionsother2 / 3completed
NCT05895994
Research Development13(RD13)-02 Cell Injection in Patients With Relapsed or Refractory Cluster Of Differentiation 7(CD7)-Positive Hematological MalignanciesNo drug interventionstreatment0recruiting
NCT01488591
Biomarker Research for Personalized MedicineNo drug interventionsNot AvailableNot Availableunknown_status
NCT02193880
Safety of Post-transplant Alpha-beta Depleted T-cell Infusion Following Haploidentical Stem Cell Transplant (Haplo SCT)No drug interventionstreatmentNot Availablecompleted
NCT02895529
A Study Comparing the Efficacy of Intravenous Followed by Oral Itraconazole With Intravenous Caspofungin For Empiric Antifungal Therapy in Neutropenic Participants With Hematological MalignancyNo drug interventionstreatment4terminated
NCT00312429
Umbilical Cord Blood Stem Cell Transplantation in Adults With Advanced Blood Disorders or CancerNo drug interventionstreatment1 / 2completed
NCT03735992
Mind-body Medicine for Patients With Malignant Hematological DiseasesNo drug interventionstreatmentNot Availablerecruiting
NCT03219268
A Study of MGD013 in Patients With Unresectable or Metastatic NeoplasmsNo drug interventionstreatment1completed
NCT00618969
Peripheral Blood Stem Cell Transplantation (PBSCT)From Haploidentical Related DonorsNo drug interventionstreatment2completed
NCT03908138
RDD Versus VDD in Newly Diagnosed Patients With Multiple MyelomaNo drug interventionstreatment4unknown_status
NCT01553461
Transplants With Unlicensed Preserved Cord BloodNo drug interventionstreatment1 / 2recruiting