Pituitary gonadotropin hypofunction (DBCOND0025204)

Identifiers

Synonyms

Gonadotropin Deficiency / Hypogonadotropic Hypogonadism / Kallman syndrome / Fertile eunuch syndrome / Secondary hypogonadism / Hypogonadotrophic hypogonadism / Gonadotrophin deficiency

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fluoxymesterone	A synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.	Sex hormone-binding globulincarrier Estrogen receptortarget Androgen receptortarget Glucocorticoid receptortarget 11-beta-hydroxysteroid dehydrogenase type 2target
Testosterone cypionate	An androgen used to treat low or absent testosterone.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 3transporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02147964	ITT-5 Mechanisms of Spermatogenesis in Man	Acyline Chorionic Gonadotropin (Human) Dutasteride Ketoconazole Testosterone	treatment	2	withdrawn