Agents for Dermatitis, Excluding Corticosteroids

Agents for Dermatitis, Excluding Corticosteroids
Accession Number

Not Available

ATC Classification
DrugDrug Description
PimecrolimusA topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.
AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
CrisaboroleA non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
DupilumabA monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
TralokinumabA monoclonal antibody directed against interleukin-13 which is used in the treatment of moderate-to-severe atopic dermatitis in patients requiring systemic therapy.
AbrocitinibA kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults.
RuxolitinibA kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.
Drugs & Drug Targets
PimecrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
PimecrolimusSerine/threonine-protein kinase mTORtarget
PimecrolimusCytochrome P450 3A4enzyme
AlitretinoinRetinoic acid receptor alphatarget
AlitretinoinRetinoic acid receptor RXR-betatarget
AlitretinoinRetinoic acid receptor gammatarget
AlitretinoinRetinoic acid receptor betatarget
AlitretinoinRetinoic acid receptor RXR-gammatarget
AlitretinoinRetinoic acid receptor RXR-alphatarget
AlitretinoinCellular retinoic acid-binding protein 2carrier
AlitretinoinCellular retinoic acid-binding protein 1carrier
AlitretinoinP-glycoprotein 1transporter
AlitretinoinInsulin-like growth factor-binding protein 3target
AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
AlitretinoinCytochrome P450 26C1target
TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
TacrolimusCytochrome P450 3A4enzyme
TacrolimusCytochrome P450 3A5enzyme
TacrolimusP-glycoprotein 1transporter
TacrolimusATP-binding cassette sub-family A member 5transporter
TacrolimusSerum albumincarrier
TacrolimusAlpha-1-acid glycoprotein 1carrier
TacrolimusSolute carrier organic anion transporter family member 1B1transporter
Cromoglicic acidProtein S100-Ptarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CrisaboroleCytochrome P450 2B6enzyme
CrisaboroleCytochrome P450 2C8enzyme
CrisaboroleCytochrome P450 2C9enzyme
DupilumabInterleukin-4 receptor subunit alphatarget
AbrocitinibCytochrome P450 2C19enzyme
AbrocitinibCytochrome P450 2C9enzyme
AbrocitinibCytochrome P450 3A4enzyme
AbrocitinibCytochrome P450 2B6enzyme
AbrocitinibTyrosine-protein kinase JAK1target
AbrocitinibP-glycoprotein 1transporter
AbrocitinibSolute carrier family 22 member 1transporter
AbrocitinibTyrosine-protein kinase JAK2target
AbrocitinibTyrosine-protein kinase JAK3target
AbrocitinibNon-receptor tyrosine-protein kinase TYK2target
AbrocitinibSerum albumincarrier
AbrocitinibSolute carrier family 22 member 8transporter
RuxolitinibTyrosine-protein kinase JAK1target
RuxolitinibTyrosine-protein kinase JAK2target
RuxolitinibCytochrome P450 3A4enzyme
RuxolitinibCytochrome P450 2C9enzyme
RuxolitinibSerum albumincarrier
RuxolitinibTyrosine-protein kinase JAK3target
RuxolitinibNon-receptor tyrosine-protein kinase TYK2target