conditioning regimens for allogeneic stem cell transplantation therapy (DBCOND0020486)

Identifiers

Synonyms

Conditioning regimens for allogeneic stem cell transplantation / Hematopoietic stem cell transplant conditioning therapy / Hematopoietic stem cell transplant conditioning / Bone marrow conditioning therapy / Bone marrow conditioning / Bone marrow conditioning regimen

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alemtuzumab	A monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.	CAMPATH-1 antigentarget Low affinity immunoglobulin gamma Fc region receptor III-Btarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget High affinity immunoglobulin gamma Fc receptor Itarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget
Busulfan	An alkylating agent used to treat chronic myelogenous leukemia.	DNAtarget Cytochrome P450 3A4enzyme Glutathione S-transferase A2enzyme Glutathione S-transferase A1enzyme Glutathione S-transferase Mu 1enzyme Glutathione S-transferase Penzyme Microsomal glutathione S-transferase 2enzyme
Carboplatin	A alkylating agent used to treat advanced ovarian cancer.	DNAtarget High affinity copper uptake protein 1transporter Protein SLC31A2transporter Xanthine dehydrogenase/oxidaseenzyme Myeloperoxidaseenzyme Glutathione S-transferase theta-1enzyme Metallothionein-1Aenzyme Metallothionein-2enzyme Superoxide dismutase [Cu-Zn]enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme NAD(P)H dehydrogenase [quinone] 1enzyme Copper-transporting ATPase 1transporter Copper-transporting ATPase 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter
Melphalan	An alkylating agent used to treat multiple myeloma, ovarian carcinoma, uveal melanoma with unresectable hepatic metastases, and for high-dose conditioning before hematopoietic stem cell transplant in patients.	DNAtarget Solute carrier family 22 member 3transporter Large neutral amino acids transporter small subunit 1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Asc-type amino acid transporter 1transporter

Clinical Trials

Not Available