Gram-Negative Bacterial Infections (DBCOND0030807)

Identifiers

Synonyms
Gram-negative infections / Gram-Negative Bacteria Infection / Gram-negative bacterial infection NOS / Gram-negative infections Bacterial infection / Gram-negative infections Bacterial Infections / Disease caused by Gram-negative bacteria (disorder) / Bacterial infection, unspecified / Bacterial infectious disease (disorder) / Bacterial infection / Bacterial Infections / Bacterial infection of unspecified site / Bacterial infectious disorders / Bacterial infection NOS / Infection bacterial

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amikacin
An aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.
Aztreonam
A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.
Benzylpenicillin
A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption.
Cefamandole
A beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections.
Cefiderocol
A cephalosporin antibiotic used in complicated urinary tract infections.
Cefodizime
A broad-spectrum, third-generation cephalosporin used to treat serious infections caused by susceptible bacteria.
No drug targets
Cefpirome
An antibiotic indicated in the treatment of a wide variety of infections in the body.
No drug targets
Demeclocycline
A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
Thiamphenicol
A semisynthetic derivative of chloramphenicol with a broad spectrum of antibacterial activity.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01431326
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareNot AvailableNot Availablecompleted
NCT05789199
Use of Cefiderocol in the Management of Gram-Negative InfectionsNot AvailableNot Availablecompleted
NCT00304330
Emergence of Gram-negative Resistance in Blood Culture Isolates of Solid-organ Transplant RecipientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04895657
Extended-infusion of Piperacillin-Tazobactam Versus Intermittent Infusiontreatment4completed
NCT04628572
Retrospective Analysis of Real World Use of Ceftazidime-avibactam in the Management of Gram Negative InfectionsNot AvailableNot Availablecompleted
NCT06462235
A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)No drug interventionsbasic_science2recruiting
NCT00723502
Efficacy and Safety Study of Finafloxacin Used in Helicobacter Pylori Infected Patientstreatment2completed
NCT05210387
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli InfectionsNo drug interventionstreatmentNot Availableterminated
NCT00490477
The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical TrialNo drug interventionsprevention3completed
NCT05639647
Study of 2 Medicines (Aztreonam and Avibactam) Compared to Best Available Therapy for Serious Gram-negative Infectionstreatment2recruiting
NCT04785924
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infectionstreatment4withdrawn
NCT02117986
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patientstreatment4unknown_status
NCT04055922
Comparison of Solid Organ TransplantNo drug interventionsNot AvailableNot Availableunknown_status
NCT04861922
Unfractioned Heparin for Treatment of Sepsis Caused by Abdominal Infectiontreatment3recruiting
NCT00177957
Gram Negative Bacteremia, Risk Factors for Failure of TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT00629382
Early Use of Polymyxin B Hemoperfusion in Abdominal SepsisNo drug interventionstreatment4completed
NCT02088840
Survey of Severe Infections by Gram Negative Bacteria in Patients Submitted to Stem Cell TransplantNo drug interventionsNot AvailableNot Availablecompleted
NCT01015014
Safety, Pharmacokinetics (PK) and Tolerability Study of a Novel Drug for Treatment of Bacterial Infectionstreatment1completed
NCT03397914
Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infectionstreatment4completed
NCT02007343
Burden of Antibiotic Resistance in Gram-Negative Infections in Dutch HospitalsNo drug interventionsNot AvailableNot Availablecompleted
NCT00394784
Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream IsolatesNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00406198
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe SepsisNo drug interventionssupportive_care4completed
NCT02285075
Temocillin Pharmacokinetic in Hemodialysistreatment4completed
NCT00563134
A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in AdultNo drug interventionstreatmentNot Availablesuspended
NCT02962934
An Observational Pharmacokinetic Sudy of Ceftolozane-Tazobactam in Intensive Care Unit in Patients With and Without CRRTNo drug interventionsNot AvailableNot Availablecompleted
NCT04335539
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participantstreatment2completed
NCT05171257
Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care UnitNo drug interventionsNot AvailableNot Availableunknown_status
NCT06086626
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infantstreatment2recruiting
NCT02666274
Feasibility Studies to Inform Novel Proposals to Avert Community-Based Antimicrobial Resistance SpreadNo drug interventionsNot AvailableNot Availableunknown_status
NCT04126031
Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants.basic_science2terminated
NCT04215991
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Pediatric Participantstreatment2recruiting
NCT04917380
The Clinical Character,Risk and Prognosis of Post-neurosurgical Intracranial Infection With Different Pathogens.No drug interventionsNot AvailableNot Availableunknown_status
NCT00079989
Study Evaluating Tigecycline in Selected Serious Infections Due to Resistant Gram-Negative Organismstreatment3completed
NCT03160040
A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World SettingNot AvailableNot Availablecompleted
NCT00874367
Early-Onset Sepsis Surveillance StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03182504
A Study to Investigate the Intrapulmonary Lung Penetration of Nacubactam in Healthy Participantstreatment1completed
NCT01600768
Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT00177814
Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT06135350
Clinical Trial to Study the Efficacy and Safety of Fluorothiazinone (N.F. Gamaleya NRCEM) in Prophylaxis of Nosocomial Bacterial Infections With Participation of Patients on MVNo drug interventionsprevention2not_yet_recruiting
NCT01732250
Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenemtreatment4completed
NCT03345992
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune Systemtreatment3completed