Puberty, Delayed (DBCOND0001010)

Identifiers

Synonyms

Puberty Delayed / Delayed Puberty / Delayed puberty (disorder) / Delay in sexual development AND/OR puberty (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fluoxymesterone	A synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.	Sex hormone-binding globulincarrier Estrogen receptortarget Androgen receptortarget Glucocorticoid receptortarget 11-beta-hydroxysteroid dehydrogenase type 2target
Methyltestosterone	A synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.	Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Androgen receptortarget Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Albumincarrier Sex hormone-binding globulincarrier Estrogen receptortarget Aromataseenzyme
Testosterone	A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.	Androgen receptortarget Cytochrome P450 3A4enzyme Aromataseenzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic anion transporter 3transporter Solute carrier family 22 member 7transporter Hepatic sodium/bile acid cotransportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget Solute carrier organic anion transporter family member 1B3transporter
Testosterone propionate	A slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.	Androgen receptortarget Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferase 1A1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Sex hormone-binding globulincarrier Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05417035	Pubertal Replacement In Boys Study Nebido and Testoviron Depot Treatment	Testosterone	treatment	Not Available	completed
NCT00494169	Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	No drug interventions	Not Available	Not Available	completed
NCT00734279	Follicle-Stimulating Hormone (FSH) and the Onset of Puberty	Ganirelix Leuprolide	basic_science	0	completed
NCT05971836	The Molecular Basis of Inherited Reproductive Disorders	No drug interventions	Not Available	Not Available	recruiting
NCT05541172	Testosterone Undecanoate Replacement Therapy in Boys With Pubertal Delay or Confirmed Hypogonadism	Testosterone undecanoate	Not Available	Not Available	recruiting
NCT02034487	Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment	No drug interventions	Not Available	Not Available	completed
NCT01626833	Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone	No drug interventions	treatment	2 / 3	completed
NCT01438034	Kisspeptin in the Evaluation of Delayed Puberty	Gonadorelin Kisspeptin	other	1	completed