Immunosuppressive Treatment (DBCOND0081801)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Antithymocyte immunoglobulin (rabbit)	A purified form of rabbit anti-thymocyte antibodies used for immunosuppression in patients receiving kidney transplants.	T-cell surface glycoprotein CD1atarget Major histocompatibility complex class I-related gene proteintarget Integrin alpha-Ltarget T-lymphocyte activation antigen CD86target Low affinity immunoglobulin gamma Fc region receptor II-btarget T-cell surface glycoprotein CD4target Integrin beta-1target Integrin alpha-Vtarget Integrin beta-3target
Basiliximab	A monoclonal anti-C25 antibody (interleukin-2 receptor alpha subunit) used as immunosuppressive therapy in kidney transplant patients.	Interleukin-2 receptor subunit alphatarget Interleukin-2 receptor subunit betatarget
Belimumab	A B-lymphocyte stimulator (BLyS)-specific inhibitor used to treat systemic lupus erythematosus and active lupus nephritis as an add-on therapy.	Tumor necrosis factor ligand superfamily member 13Btarget
Caplacizumab	A von Willebrand factor (vWF)-directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP).	von Willebrand factortarget
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.	Thrombopoietin receptortarget Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme Solute carrier organic anion transporter family member 1B1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A9enzyme
Tacrolimus	A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.	Peptidyl-prolyl cis-trans isomerase FKBP1Atarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Cholesterol transporter ABCA5transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Solute carrier organic anion transporter family member 1B1transporter Protein phosphatase 3 catalytic subunit alphatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03015974	Registry of IgA Nephropathy in Chinese Children	Angiotensin II Cyclophosphamide Deflazacort Dipyridamole Methylprednisone Mycophenolate mofetil Prednisolone Prednisone	Not Available	Not Available	recruiting
NCT03791827	Multicenter Registry of Pediatric Lupus Nephritis in China	Azathioprine Cyclophosphamide Cyclosporine Hydroxychloroquine Methylprednisone Mycophenolate mofetil Prednisolone Prednisone Rituximab Tacrolimus	Not Available	Not Available	recruiting