Uncomplicated Malaria caused by Plasmodium falciparum

Also known as: Uncomplicated Falciparum Malaria / Uncomplicated P. Falciparum Malaria / Plasmodium Falciparum Malaria (Uncomplicated) / Uncomplicated Plasmodium Falciparum Malaria

DrugDrug NameDrug Description
DB01611HydroxychloroquineAn antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.
DB06708LumefantrineAn antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.
DB00468QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
DrugDrug NameTargetType
DB01611HydroxychloroquineDNAtarget
DB01611HydroxychloroquineToll-like receptor 7target
DB01611HydroxychloroquineToll-like receptor 9target
DB01611HydroxychloroquineCytochrome P450 2D6enzyme
DB01611HydroxychloroquineP-glycoprotein 1transporter
DB01611HydroxychloroquineSerum albumincarrier
DB01611Hydroxychloroquinealpha1-acid glycoproteincarrier
DB01611HydroxychloroquineCytochrome P450 3A4enzyme
DB01611HydroxychloroquineSolute carrier organic anion transporter family member 1A2transporter
DB01611HydroxychloroquineAngiotensin-converting enzyme 2target
DB01611HydroxychloroquineCytochrome P450 2C8enzyme
DB06708LumefantrineCytochrome P450 2D6enzyme
DB06708LumefantrineCytochrome P450 3A4enzyme
DB00468QuininePlatelet glycoprotein IXtarget
DB00468QuinineIntermediate conductance calcium-activated potassium channel protein 4target
DB00468QuinineCytochrome P450 3A4enzyme
DB00468QuinineCytochrome P450 3A5enzyme
DB00468QuinineCytochrome P450 1A1enzyme
DB00468QuinineCytochrome P450 2D6enzyme
DB00468QuinineCytochrome P450 1A2enzyme
DB00468QuinineCytochrome P450 2C8enzyme
DB00468QuinineCytochrome P450 2C9enzyme
DB00468QuinineCytochrome P450 2C19enzyme
DB00468QuinineCytochrome P450 2E1enzyme
DB00468QuinineCytochrome P450 3A7enzyme
DB00468QuinineSolute carrier family 22 member 2transporter
DB00468QuinineSolute carrier family 22 member 1transporter
DB00468QuinineSolute carrier family 22 member 5transporter
DB00468QuinineP-glycoprotein 1transporter
DB00468QuinineSolute carrier organic anion transporter family member 1A2transporter
DB00468QuinineSolute carrier family 22 member 4transporter
DB00468QuinineFe(II)-protoporphyrin IXtarget
DB00468QuinineSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB00613Amodiaquine2Completed1
DB09274Artesunate2Completed4
DB00207Azithromycin2Completed1
DB00608Chloroquine2Completed1
DB12306Cipargamin2Recruiting1
DB16173Ganaplacide2Recruiting1
DB06708Lumefantrine2Recruiting1
DB13085Lumefantrine co-artemether2Recruiting2
DB09241Methylene blue2Completed1
DB01087Primaquine2Completed1
DB00205Pyrimethamine2Completed1
DB12975Pyronaridine2Completed1
DB01299Sulfadoxine2Completed1
DB00613Amodiaquine2 / 3Not Yet Recruiting1
DB11809Artefenomel2 / 3Completed1
DB06697Artemether2 / 3Active Not Recruiting1
DB06697Artemether2 / 3Not Yet Recruiting1
DB16097Artemisone2 / 3Withdrawn1
DB11638Artenimol2 / 3Active Not Recruiting1
DB11638Artenimol2 / 3Withdrawn1
DB09274Artesunate2 / 3Not Yet Recruiting1
DB09274Artesunate2 / 3Withdrawn1
DB06708Lumefantrine2 / 3Active Not Recruiting1
DB06708Lumefantrine2 / 3Not Yet Recruiting1
DB13085Lumefantrine co-artemether2 / 3Active Not Recruiting1
DB00358Mefloquine2 / 3Withdrawn1
DB13941Piperaquine2 / 3Active Not Recruiting1
DB13941Piperaquine2 / 3Completed1
DB00613Amodiaquine3Not Yet Recruiting1
DB00613Amodiaquine3Recruiting2
DB06697Artemether3Not Yet Recruiting1
DB06697Artemether3Recruiting2
DB11638Artenimol3Completed1
DB09274Artesunate3Completed1
DB09274Artesunate3Not Yet Recruiting1
DB09274Artesunate3Recruiting2
DB00608Chloroquine3Completed1
DB06708Lumefantrine3Not Yet Recruiting1
DB06708Lumefantrine3Recruiting2
DB13085Lumefantrine co-artemether3Not Yet Recruiting1
DB00358Mefloquine3Recruiting2
DB13941Piperaquine3Completed1
DB13941Piperaquine3Recruiting2
DB00205Pyrimethamine3Completed1
DB00613Amodiaquine4Active Not Recruiting1
DB00613Amodiaquine4Completed1
DB00613Amodiaquine4Unknown Status1
DB06697Artemether4Active Not Recruiting1
DB06697Artemether4Completed1
DB11638Artenimol4Completed1
DB09274Artesunate4Active Not Recruiting1
DB09274Artesunate4Completed1
DB09274Artesunate4Unknown Status1
DB06708Lumefantrine4Active Not Recruiting1
DB06708Lumefantrine4Completed1
DB13085Lumefantrine co-artemether4Active Not Recruiting1
DB13085Lumefantrine co-artemether4Completed1
DB13085Lumefantrine co-artemether4Unknown Status1
DB00358Mefloquine4Unknown Status1
DB13941Piperaquine4Completed1
DB09274ArtesunateNot AvailableCompleted1
DB13941PiperaquineNot AvailableSuspended1
DB01087PrimaquineNot AvailableSuspended1
DB00205PyrimethamineNot AvailableCompleted1
DB01299SulfadoxineNot AvailableCompleted1