Hansen's Disease (DBCOND0064479)

Identifiers

Synonyms

Leprosy / Hansen Disease / Hansen's disease / Leprosy, unspecified / Leprosy NOS / Leprosy (disorder) / Mycobacterium leprae infection NOS / Leprosy [Hansen's disease] / Leprous infections

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Brilliant green cation	An ingredient used in topical medications to prevent infections of the umbilical cord.	No drug targets
Dapsone	A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.	Inactive dihydropteroate synthase 2target Dihydropteroate synthasetarget Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Flavin-containing monooxygenase 3enzyme Prostaglandin G/H synthase 1enzyme Prostaglandin G/H synthase 2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Arylamine N-acetyltransferase 2enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Myeloperoxidaseenzyme Cytochrome P450 2C18enzyme
Ofloxacin	An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Organic cation/carnitine transporter 2transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Bile salt export pumptransporter DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Protionamide	An antitubercular thioamide-derivative used in the treatment of multi-drug resistant (MDR) tuberculosis and leprosy.	Enoyl-[acyl-carrier-protein] reductase [NADH]target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05091216	The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients	No drug interventions	prevention	Not Available	completed
NCT01885611	Virgin Coconut Oil Oral Supplementation for Leprosy Patients	No drug interventions	supportive_care	1 / 2	withdrawn
NCT05047809	The Effect of "Jinchuang Ointment" (JCO) on the Treatment of Wounds in Patients With Hansen's Disease.	No drug interventions	treatment	Not Available	completed
NCT05031091	Epidemiology of Leprosy in French Guiana	No drug interventions	Not Available	Not Available	unknown_status
NCT06627257	Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for Leprosy	G100	prevention	1	not_yet_recruiting
NCT01751503	Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer	No drug interventions	treatment	Not Available	terminated
NCT06416033	Serum Irisin Level In Leprosy Patients	No drug interventions	Not Available	Not Available	recruiting
NCT03683745	Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia	No drug interventions	Not Available	Not Available	completed
NCT00406861	Montelukast in ENL Reaction	Montelukast	treatment	Not Available	unknown_status
NCT00128193	Leprosy Skin Test Antigens Trial	Tuberculin purified protein derivative	diagnostic	2	completed
NCT00919815	Ciclosporin in the Management of New Type 1 Reactions in Leprosy	Cyclosporine Prednisolone	treatment	2 / 3	completed
NCT03947437	Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients	G100	treatment	1 / 2	not_yet_recruiting
NCT01006759	Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients	No drug interventions	prevention	1	completed
NCT03526718	Improved Understanding of Ongoing Transmission of Leprosy in the Hyperendemic Comoros (ComLep)	No drug interventions	Not Available	Not Available	completed
NCT03324035	Treatment of Neuropathic Pain in Leprosy	Amitriptyline Tramadol	treatment	3	unknown_status
NCT03662022	Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar	Rifampin	prevention	3	completed
NCT03807362	CC-11050 Trial in Nepalese Patients With Erythema Nodosum Leprosum	Dovramilast	treatment	2	recruiting
NCT02550080	Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome	Dapsone	treatment	4	unknown_status
NCT05597280	Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy	Bedaquiline Rifampin	prevention	3	recruiting
NCT06222372	Novel Interventions and Diagnostic Tests for Leprosy	Rifampin	prevention	Not Available	recruiting
NCT02484469	Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial	No drug interventions	Not Available	Not Available	completed
NCT01920750	Leprosy Skin Test Antigens Phase 1	No drug interventions	diagnostic	1	completed
NCT05406479	Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2)	Bedaquiline Rifampin	prevention	2	completed
NCT05243654	Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy	Metformin	treatment	2	recruiting
NCT00919451	Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy	Cyclosporine	treatment	2	completed
NCT00852345	Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy	No drug interventions	Not Available	Not Available	no_longer_available
NCT03302897	Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers	G100	prevention	1	completed
NCT00315809	Molecular Epidemiology of Leprosy - Philippines	No drug interventions	Not Available	Not Available	completed
NCT00138437	Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses	No drug interventions	Not Available	Not Available	completed
NCT00919542	Ciclosporin in the Management of New Erythema Nodosum Leprosum	Cyclosporine Prednisolone	treatment	2	completed
NCT00860717	The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients	No drug interventions	treatment	Not Available	completed
NCT00919776	Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum	Cyclosporine Prednisolone	treatment	2	completed
NCT01165840	Effect of Weight and/or Obesity on Dapsone Drug Concentrations	Dapsone	treatment	4	completed
NCT03084614	CD8 Reactivity to Microorganisms in Blood and Breast Milk	No drug interventions	Not Available	Not Available	terminated
NCT00669643	Uniform Multidrug Therapy Regimen for Leprosy Patients	Clofazimine Dapsone Rifampin	treatment	4	completed