Genotype 4 Chronic Hepatitis C (DBCOND0074476)

Identifiers

Synonyms

Chronic hepatitis C genotype 4 / Hepatitis C virus genotype 4 / Hepatitis C virus genotype 4 (organism) / Chronic viral hepatitis C / Chronic hepatitis C (disorder) / Hepatitis C, Chronic / Chronic hepatitis C

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Asunaprevir	An NS3 protease inhibitor used to treat hepatitis C genotype 1b.	Genome polyproteintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter Gag-Pol polyproteintarget
Elbasvir	An antiviral and NS5A inhibitor used to treat hepatitis C infections.	Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 3A43enzyme
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.	Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter NS3 proteasetarget Cytochrome P450 3A4enzyme Genome polyproteintarget
Grazoprevir	An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections.	ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Cytochrome P450 3A4enzyme Genome polyproteintarget Albumincarrier Alpha-1-acid glycoprotein 1carrier
Ledipasvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Genome polyproteintarget
Pibrentasvir	A Hepatitis C NS5A inhibitor used to treat Hepatitis C.	Nonstructural protein 5Atarget Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Simeprevir	A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.	NS3 proteasetarget Albumincarrier Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 2B1transporter Hepatic sodium/bile acid cotransportertransporter Bile salt export pumptransporter Genome polyproteintarget Genome polyproteintarget
Sofosbuvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter RNA-dependent RNA-polymerasetarget Lysosomal protective proteinenzyme Carboxylesteraseenzyme Adenosine 5'-monophosphoramidase HINT1enzyme UMP-CMP kinaseenzyme Nucleoside diphosphate kinase Aenzyme Genome polyproteintarget
Velpatasvir	A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis.	Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02250807	Efficacy and Safety Study of Simeprevir in Combination With Sofosbuvir in Subjects With Chronic Genotype 4 Hepatitis C Virus Infection	Simeprevir Sofosbuvir	treatment	3	completed