Perioperative analgesia (DBCOND0024220)

Identifiers

Synonyms

Peri Operative Analgesia / Perioperative analgesia therapy

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alfentanil	An opioid agonist used to induce and maintain anesthesia, as well as an analgesic.	Mu-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier Albumincarrier Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter
Methotrimeprazine	A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.	D(3) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Cytochrome P450 2D6enzyme D(2) dopamine receptortarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(4) dopamine receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget Cytochrome P450 2E1enzyme
Nalbuphine	An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.	Kappa-type opioid receptortarget Mu-type opioid receptortarget Delta-type opioid receptortarget
Oxymorphone	An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.	Mu-type opioid receptortarget Cytochrome P450 2D6enzyme Delta-type opioid receptortarget Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05631834	ESP Versus TEA for Oeasophagus Cancer Surgery	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT04259502	Rhomboid Intercostal Block vs Erector Spina Plan Block for Peri-operative Analgesia in Mastectomy	No drug interventions	treatment	Not Available	unknown_status
NCT03105193	Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections	Lidocaine	treatment	4	completed
NCT06210503	PENG Block in Comparison With FICB for Hip Reconstruction in Children	No drug interventions	treatment	Not Available	recruiting
NCT05862922	Comparison Effects of Two Regional Anesthetic Technique on Pain During High Risk Hip Fracture Surgery	No drug interventions	Not Available	Not Available	recruiting
NCT05504265	Perioperative Analgesia Modes in Minimally Invasive Esophagectomy	Flurbiprofen axetil	treatment	2 / 3	unknown_status