Pure Red Cell Aplasia (DBCOND0028424)

Identifiers

Synonyms

Red-Cell Aplasia, Pure / Aplasia, pure red cell / Pure red cell aplasia (PRCA) / Pure red cell aplasia / Aplasia pure red cell / Red cell aplasia / Pure red cell aplasia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Bupivacaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 10 subunit alphatarget Prostaglandin E2 receptor EP1 subtypetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme
Hydrocortisone succinate	A corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.	Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Annexin A1target 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme 11beta-hydroxysteroid dehydrogenaseenzyme Albumincarrier
Methylprednisolone hemisuccinate	A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00210951	Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin	No drug interventions	Not Available	Not Available	completed
NCT00211029	A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant Erythropoietins	No drug interventions	Not Available	Not Available	completed
NCT00005893	Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders	Busulfan Cyclophosphamide	treatment	Not Available	completed
NCT00315419	Identifying Characteristics of Bone Marrow Failure Syndromes	No drug interventions	Not Available	Not Available	unknown_status
NCT00229619	Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia	Rituximab	treatment	2	completed
NCT02648126	Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa	No drug interventions	diagnostic	4	unknown_status
NCT03364764	Sirolimus Treatment for Refractory PRCA	Sirolimus	treatment	4	completed
NCT00004143	Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes	Alemtuzumab	treatment	2	completed
NCT00391287	Surveillance Study to Estimate the Incidence of Pure Red Blood Cell Aplasia Among Patients With Chronic Kidney Failure	No drug interventions	Not Available	Not Available	completed
NCT03214354	Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor	Alemtuzumab Sirolimus	treatment	2	recruiting
NCT06065852	National Registry of Rare Kidney Diseases	No drug interventions	Not Available	Not Available	recruiting
NCT03918265	Tacrolimus Treatment for Refractory Autoimmune Cytopenia	Tacrolimus	treatment	4	unknown_status
NCT00001962	A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure	Daclizumab	treatment	2	terminated
NCT00211068	A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa	Erythropoietin	Not Available	Not Available	completed
NCT00314795	Efficacy and Safety of Peginesatide (AF37702) in the Treatment of Anemia in Participants With Chronic Kidney Disease	Peginesatide	treatment	2	completed
NCT01362595	Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia	Leucine	treatment	1 / 2	completed
NCT00006055	Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases	Cyclophosphamide Cyclosporine Filgrastim Methylprednisolone Prednisone	treatment	Not Available	unknown_status
NCT03966053	The Use of Trifluoperazine in Transfusion Dependent DBA	Trifluoperazine	treatment	1 / 2	terminated
NCT00004378	Stem Cell Transplantation (SCT) for Genetic Diseases	No drug interventions	treatment	Not Available	completed
NCT00211042	A Study of Patients With Pure Red Cell Aplasia Associated With Recombinant Human Erythropoietin Treatment	No drug interventions	Not Available	Not Available	completed
NCT03540472	Tacrolimus Treatment for Refractory PRCA	Tacrolimus	treatment	4	unknown_status