Severe Asthma (DBCOND0039302)

Identifiers

Synonyms
Severe asthma / Severe asthma (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Betamethasone
A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
Dupilumab
A monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
Epinephrine
A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
Omalizumab
A monoclonal anti-immunoglobulin E (IgE) antibody used to treat asthma, chronic idiopathic urticaria, chronic rhinosinusitis with nasal polyps, and IgE-mediated food allergy.
Prednisolone
A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
Tezepelumab
A human monoclonal IgG2λ thymic stromal lymphopoietin (TSLP)-blocking antibody for add-on maintenance therapy in severe asthma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06389058
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare SystemNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04520165
Effect of Biologicals on Alternative Functions of Eosinophils in Severe AsthmaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06625216
Severe Asthma Network ItalyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06035289
Register Schweres Asthma - German Asthma Net e.V.No drug interventionsNot AvailableNot Availablerecruiting
NCT06283290
PROPE Severe Asthma Study in EgyptNo drug interventionsNot AvailableNot Availablerecruiting
NCT06487065
Observational Retrospective Study To Characterize and Assess Clinical Outcomes of Patients Receiving Tezepelumab in the Framework Of Use in Special Situations Prior to Commercialisation in SpainNo drug interventionsNot AvailableNot Availablerecruiting
NCT06196879
A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)treatment2recruiting
NCT06472310
Clinical and demOgRaphic Features of Patients With Uncontrolled Severe Asthma in Russia (CORSAR)No drug interventionsNot AvailableNot Availablerecruiting
NCT06566885
Real-world Study Assessing Efficacy of TezepeLumaB in Patients With Severe Asthma Regardless of Phenotype in RussiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT04048343
Long-term Safety of Tezepelumab in Japanese Subjects With Inadequately Controlled Severe Asthmatreatment3completed
NCT06024902
Clinical Characteristics of Severe Childhood AsthmaNo drug interventionsNot AvailableNot Availablecompleted
NCT06473779
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.treatment3not_yet_recruiting
NCT04045587
International Severe Asthma Registry: Canadian CohortNo drug interventionsNot AvailableNot Availableunknown_status
NCT03931954
Prevalence of the Eosinophilic Phenotype Among Severe Asthma PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04022447
Dupilumab for Severe Asthma in a Real Life SettingNot AvailableNot Availablecompleted
NCT04565483
Predictive Signature of Benralizumab Responseother4recruiting
NCT04914078
Severe Asthma Exacerbations and Mepolizumab TreatmentNot AvailableNot Availableunknown_status
NCT03476109
Study of Magnitude and Prediction of Response to Omalizumab and Mepolizumab in Adult Severe Asthma.treatment4recruiting
NCT03532685
Clinical, Inflammatory and Functional Evaluation of a Population of Severe and Obese Asthmatics: Follow upNo drug interventionssupportive_careNot Availableunknown_status
NCT03925415
BRazilian Asthmatics Patients EOSinophilic Profile (BRAEOS)No drug interventionsNot AvailableNot Availablecompleted
NCT03435237
Phenotyping Asthma for Bronchial ThermoplastyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05018299
Evaluate the Efficacy and Safety of FB704A in Adult With Severe AsthmaNo drug interventionstreatment2recruiting
NCT04463836
Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA)No drug interventionsNot AvailableNot Availableunknown_status
NCT02114034
Cohort Analysis of Clinical and Biological Severe Childhood AsthmaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02433535
Trial of Simvastatin for the Treatment of Severe Asthmatreatment2withdrawn
NCT04272463
ChAracterisation of ItaliaN Severe Uncontrolled Asthmatic patieNts Key Features When Receiving BenralizumabNo drug interventionsNot AvailableNot Availablecompleted
NCT05164939
Precision Medicine Intervention in Severe Asthma (PRISM) StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03387722
Assessment of Treatment Patterns of Severe Asthmatic Patients Across the Gulf Region - SevEos StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03608566
Russian Severe Asthma RegistryNo drug interventionsNot AvailableNot Availableunknown_status
NCT03377920
Predictive Value of Spirometric PIF to Produce PIF Rate Needed for the Use of Current DPI's.No drug interventionsotherNot Availableunknown_status
NCT03629782
Characterisation of Patients With Severe Asthma in Primary and Secondary Care Settings in Europe Reported to be Eligible for Biological TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT04334031
Deployment o the Multidisciplinary Prospective Cohort ImminentNo drug interventionsotherNot Availablerecruiting
NCT04108962
Benralizumab in the Treatment of Patients With Severe Asthma With ABPAtreatment4withdrawn
NCT05001529
Flow Cytometry Analysis of Eosinophils in Severe Asthma Patients.No drug interventionsdiagnostic4unknown_status
NCT03784781
Type 2 Innate Lymphoid Cells in Severe Pediatric AsthmaNo drug interventionsNot AvailableNot Availablewithdrawn
NCT05946421
The BASA Study: Breath Analysis for Severe Asthma PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06421402
K-HEALTH in AIR - Barcelona Pilot - CohortNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04221802
Patient-reported Outcomes in Real-world Use of Benralizumab in Patients With Severe Eosinophilic Asthma in BelgiumNo drug interventionsNot AvailableNot Availablecompleted
NCT02975284
Unraveling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma (TASMA) Extension StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05576454
Evaluate the Pharmacokinetics of BAT2606 Injection in Healthy Chinese Male Subjectstreatment1completed
NCT03984253
Swiss Severe Asthma RegisterNo drug interventionsNot AvailableNot Availablerecruiting
NCT05603845
Patient-Reported OUTcomes of Benralizumab in Real-World Use in Severe EosiNophilic Asthma PatientsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04031261
National Validation and Sensitivity to Change of the SAQNo drug interventionsNot AvailableNot Availablecompleted
NCT03361111
BIOmarkers in Severe AsthMa Patients on Omalizumab TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT05032209
Follow-up of Children With Severe Asthma at Adult AgeNo drug interventionsNot AvailableNot Availableunknown_status
NCT04612556
Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO)Not AvailableNot Availableactive_not_recruiting
NCT03074942
Reslizumab in Patients With Severe Asthma Who Failed to Respond to Omalizumabtreatment2completed
NCT01350336
Bronchial Thermoplasty in Severe Persistent AsthmaNo drug interventionstreatmentNot Availablecompleted
NCT06239441
Effectiveness of Anti-IL-5/IL5R InhibitorsNot AvailableNot Availablecompleted
NCT04680117
Defining the Severe Paediatric Asthma EndotypeNo drug interventionsotherNot Availablerecruiting
NCT05472324
Evaluate the Efficacy and Safety of TQC2731 Injection in Patients With Severe Asthma.No drug interventionstreatment2recruiting
NCT01961258
"SEVERE ASTHMA" in the COMMUNITYNo drug interventionsNot AvailableNot Availableunknown_status
NCT04648839
Observational Retrospective Study on Clinical Outcomes of Patients Receiving Benralizumab in Spain.No drug interventionsNot AvailableNot Availablecompleted
NCT02038374
Clinico-biological Correlation of Severe Asthma in ChildrenNo drug interventionsNot AvailableNot Availableunknown_status
NCT03065920
African Severe Asthma Program: A Research Network for Characterisation of Severe Asthma in Africans (ASAP)No drug interventionsNot AvailableNot Availablecompleted
NCT05762627
Severe Eosinophilic Asthma Phenotypes During Childhood Have Various OriginsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06455462
Patient Characteristics, Treatment Patterns and Outcomes of Patients Enrolled in the Tezepelumab Patient Access Programme; a Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma CentresNot AvailableNot Availablerecruiting
NCT06126692
3TR Asthma Biologics Cohort (ABC) StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04714567
Portuguese Severe Asthma Registry: Getting Answers for Severe Asthma PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00621946
Treatment of Outpatients With Severe Asthma and Moderate or Severe Major Depressive Disordertreatment4completed
NCT05147155
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor InitiationNot AvailableNot Availablecompleted
NCT04980755
Adapting Body Reprogramming for Severe Asthma: a Feasibility StudyNo drug interventionsotherNot Availableunknown_status
NCT05331755
Real Life Experience Survey of Dupilumab in the NetherlandsNot AvailableNot Availablecompleted
NCT04438408
National Survey on Care Pathway and Quality of Life in Patients With Severe Asthma According to Their Phenotype.No drug interventionsNot AvailableNot Availableunknown_status
NCT05616338
Modeling Bronchial Epithelium in Severe Asthma With Human Induced Pluripotent Stem Cells (iPSC)No drug interventionsotherNot Availablecompleted