Chronic Liver Disease (DBCOND0036087)

Identifiers

Synonyms
Liver Disease Chronic / Chronic Liver Disease (CLD) / Chronic Liver Diseases (CLD) / Chronic Liver Diseases / Focal liver disease / Chronic liver disease / Chronic liver disease (disorder) / Liver disease, unspecified / Hepatopathy / Hepatic disease NOS / Disorder hepatic / Hepatic disorder NOS / Disease hepatocellular / Disorder liver / Hepatic disease / Liver disorder / Liver Diseases / Unspecified disorder of liver / Disorder of liver (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ademetionine
S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
Avatrombopag
A thrombopoietin receptor agonist used pre-operatively to treat thrombocytopenia in patients with chronic liver disease and in patients with chronic refractory thrombocytopenia.
Gadoxetic acid
A gadolinium-based contrast agent (GBCA) used with contrasted magnetic resonance imaging (MRI) to detect and visualize the liver.
Lusutrombopag
A medication used to treat thrombocytopenia in patients with chronic liver disease scheduled to have a procedure.
Metenolone
An anabolic steroid indicated in the treatment and prevention of muscle wasting due to diseases, drug treatments, or other catabolic processes.
No drug targets
Plasma protein fraction (human)
A plasma protein solution used to treat coagulation factor deficiencies, reverse anticoagulant effects, and shock from a loss of plasma fluids, and is also used in plasma exchange procedures.
No drug targets
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05205954
HepHospital: A Hepatology Home Hospital Intervention for Patients With Advanced Liver DiseaseNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT05062967
Evaluation of Orthohepevirus C Infection as an Emerging Cause of Zoonotic Origin DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03130608
Inspiratory Muscle Training Post-Liver TransplantNo drug interventionstreatmentNot Availablecompleted
NCT03459521
Efficacy of HBVaxpro40© and Fendrix© in Patients With Chronic Liver Disease.otherNot Availablecompleted
NCT05017805
COVID-19 Vaccines in Patients With Chronic Liver DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT05956015
Albumin Catabolic Rate Measured by a Stable IsotopeNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT06111859
Effectiveness of Ultrasound in Liver Stiffness and Fat QuantificationNo drug interventionsdiagnosticNot Availablerecruiting
NCT04339725
Gut Microbiota Metagenomics for Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05998330
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver DiseaseNo drug interventionssupportive_careNot Availablerecruiting
NCT05193201
A Phase Ib Clinical Study for rhTPO in the Treatment of Thrombocytopenia in Patients With Chronic Liver Diseasetreatment1unknown_status
NCT05729269
Characterization of Gut Microbiota in Chronic Liver Disease With Decreased Muscle MassNo drug interventionsNot AvailableNot Availablecompleted
NCT02187601
Equivalence of New Breath AnalyzerCompared to Currently BreathID System in Assessment of Liver FunctionNo drug interventionsdiagnosticNot Availablecompleted
NCT01900808
Improvement of Transient Elastography Applicability and Diagnostic Accuracy to Identify Significant Fibrosis by Experienced Operators Using the M and XL Probe.No drug interventionsNot AvailableNot Availablecompleted
NCT02272504
A Protocol of the Canadian Prospective Study for Hepatocellular Carcinoma Surveillance Using BiomarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT02653846
Correlation of Liver and Spleen Stiffness by RT-2D-SWE and Severity of Portal Hypertension by HVPGNo drug interventionsNot AvailableNot Availableunknown_status
NCT05865691
Role of Coagulation, Inflammation and Vessels in Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT00629603
Polymorphisms of Fibrosis-Relating Genes on Outcome of HCV-Related Chronic Liver DiseaseNo drug interventionsbasic_scienceNot Availablecompleted
NCT05036603
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm NewbornsNo drug interventionstreatmentNot Availablecompleted
NCT05335603
An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic SteatosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01756690
Predicting Lung Injury From Transfusion in Patients With Liver DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT03440164
Superior Silybin Bioavailability in Healthy VolunteersNo drug interventionsNot AvailableNot Availablecompleted
NCT02389621
Safety and Efficacy Study of Lusutrombopag for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Elective Invasive Procedurestreatment3completed
NCT02652221
Determination of Liver Stiffness in Chronic Liver Disease Patients by Acoustic Radiation Force Imaging (ARFI) UltrasoundNo drug interventionsdiagnosticNot Availablecompleted
NCT04439084
COVID-19 in Patients With Chronic Liver DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT05312853
Evaluating the Diagnostic and Predictive Value of Non-invasive Tests (NITs) on the Progression of Chronic Liver Disease.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02859753
Comparison of Response and Recurrence Rates Following Percutaneous Microwave Coagulation Therapy Versus Percutaneous Radiofrequency AblationNo drug interventionsotherNot Availablecompleted
NCT03847753
Exploring the Comorbidity Between Mental Disorders and General Medical ConditionsNo drug interventionsNot AvailableNot Availablecompleted
NCT04588077
Comparison Between 2-dose Versus 3-dose Regimens of Heplisav B in Cirrhosisprevention4recruiting
NCT04751045
Comparison and Outcomes of Endoscopic Ultrasound Liver Biopsies Versus Percutaneous Liver BiopsiesNo drug interventionsdiagnosticNot Availablecompleted
NCT06387745
Referral of Patients to Hepatology With HepatoscopeNo drug interventionsscreeningNot Availablenot_yet_recruiting
NCT04146805
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BLD-0409 in Healthy Subjectstreatment1completed
NCT01600105
Detection of Liver Fibrosis With Magnetic Resonance Imaging (MRI)diagnostic4completed
NCT02802761
Nutritional Assessment Tool in Childhood Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01008293
Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Lifetreatment2 / 3completed
NCT00756171
Colesevelam Versus Placebo in Cholestatic Pruritustreatment2 / 3completed
NCT06227988
ASSESSMENT OF SURGICAL RISK IN PATIENTS WITH CHRONIC LIVER DISEASE USING VOCAL PENN SCORENo drug interventionsNot AvailableNot Availablerecruiting
NCT04099407
Pirfenidone and Advanced Liver Fibrosis.treatment2completed
NCT01644656
Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)No drug interventionsdiagnosticNot Availablecompleted
NCT00599352
Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease PatientsNo drug interventionsdiagnosticNot Availableterminated
NCT02184000
The Role of Strain Elastography in Staging Liver FibrosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04384159
Combination Diagnostic Strategies in NAFLDNo drug interventionsNot AvailableNot Availablecompleted
NCT02949375
Trial to Examine the Effect of Two Doses of GRI-0621 in Patients With Chronic Liver DiseaseNo drug interventionstreatment2terminated
NCT06493799
In Patients With Chronic Liver Diseases(Alcoholic Liver Disease and Non-Alcoholic Fatty Liver Disease), LAENNEC(Human Placenta Hydrolysate) is to Evaluate the Efficacy and Safety of Intravenous Droptreatment3not_yet_recruiting
NCT00630006
Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT04622449
Etiopathogenesis of Anemia in Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT01825213
Stratification of Patients With Chronic Liver Disease Using Multi Spectral CTNo drug interventionsNot AvailableNot Availablecompleted
NCT02347319
To Evaluate the Efficacy of DDB/Garlic Oil in Patients With Elevated Transaminase Chronic Liver Diseasetreatment4completed
NCT05809141
Comparison Between Thromboelastography and Conventional Coagulation Tests in Pediatrics With Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04022941
Efficacy and Safety of Sodium Benzoate in the Management of Hyperammonemia in Infants, Children and Adolescent With Chronic Liver Disease.treatmentNot Availablecompleted
NCT05296434
Delta Radiomics for Liver Function EvaluationNo drug interventionsNot AvailableNot Availableunknown_status
NCT02973516
Proof of Concept Study Concerning Efficacy of P03277 MR Imaging in HCC Diagnosisdiagnostic2completed
NCT03583996
The SHUNT-V Study for VaricesNo drug interventionsdiagnosticNot Availablecompleted
NCT05241158
Impact of Counselling and Visual Aid on Anxiety in Endoscopic PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT06160635
D-SOLVE Cohorts (Cohort A and B)No drug interventionsNot AvailableNot Availablerecruiting
NCT05097963
A Study to Evaluate Liver Stiffness With Shear Wave ElastographyNo drug interventionsdiagnosticNot Availablecompleted
NCT00629486
Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular CarcinomaNo drug interventionsbasic_scienceNot Availablecompleted
NCT01283230
Evaluation of Liver Fibrosis Staging With Acoustic Radiation Force Impulse ElastographyNo drug interventionsNot AvailableNot Availablecompleted
NCT03246048
Long Term Follow-up of Hepatitis C Cured PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02359266
Vitamin D Improves Depression in Liver PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01384565
G-CSF and Erythropoetin in Survival of Patients With Decompensated Liver Diseasetreatment3completed
NCT02060565
Prognosis Value of Non-invasive Methods for the Diagnosis of Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01205074
¹³C-Methacetin Breath Test (MBT) Methodology StudyNot Available2 / 3unknown_status
NCT06432582
hepatomiR cACLD StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05661331
VIATORR Device RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02084160
Prediction Value of the BreathID 13C-Methacetin Breath Test for Hepatic DecompensationNo drug interventionsNot AvailableNot Availablecompleted
NCT06267794
Prolonged Release Pirfenidone Versus Placebo in Compensated Cirrhosis.treatment2completed
NCT02294292
Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and MortalitytreatmentNot Availablecompleted
NCT03704792
Validation of the Second Generation of the Controlled Attenuation Parameter (CAP) Using the MRI-PDFF as ReferenceNo drug interventionsdiagnosticNot Availablecompleted
NCT03087344
Postprandial Liver and Spleen Stiffness Measurements in the Noninvasive Diagnosis of CirrhosisNo drug interventionsdiagnosticNot Availablecompleted
NCT00736840
BreathID 13C-Methacetin Breath Test for Detecting CirrhosisNo drug interventionsdiagnostic3completed
NCT02037867
Nottingham Community Liver Biomarkers CohortNo drug interventionsNot AvailableNot Availablerecruiting
NCT02530567
Non-invasive Evaluation of Portal Pressure by MRINo drug interventionsbasic_scienceNot Availableterminated
NCT03212872
Blood Ammonia as Predictor for Esophageal Varices and Risk of BleedingNo drug interventionsscreeningNot Availableunknown_status
NCT00945568
Preoperative Oral Supplementation With Branched-Chain Amino Acids (BCAA) Improves Postoperative Quality of LifeNo drug interventionssupportive_careNot Availablecompleted
NCT05095714
FAST-IRM for HCC suRveillance in pAtients With High risK of Liver Cancer.No drug interventionsscreeningNot Availablenot_yet_recruiting
NCT01314508
Increlex Treatment of Children With Chronic Liver Disease and Short StaturetreatmentNot Availablewithdrawn
NCT04455464
Effect of Midodrine on HVPG in Advanced Chronic Liver DiseasetreatmentNot Availablecompleted
NCT00402402
Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver DiseaseNo drug interventionsdiagnostic4completed
NCT00424684
Comparison of the Quantiferon®-TB GOLD (in Tube) Assay With Tuberculin Skin Testing for Detecting Latent Tuberculosis Infection in Patients With Chronic Liver Disease Being Evaluated for or Awaiting Liver TransplantationNo drug interventionsdiagnosticNot Availablewithdrawn
NCT03492879
Non Invasive Electrical Impedance Technology (EIT) for Diagnosing Liver Diseases SeverityNo drug interventionsdiagnosticNot Availableunknown_status
NCT04915287
Efficacy of Avatrombopag in Thrombocytopenic Patients With Chronic Liver Disease Undergoing an Elective Proceduretreatment4recruiting
NCT00678587
Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedurestreatment3terminated
NCT01948687
Real Time Elastography in Liver FibrosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04802954
Risk Stratification of Hepatocarcinogenesis Using a Deep Learning Based Clinical, Biological and Ultrasound Model in High-risk PatientsNo drug interventionsdiagnosticNot Availablerecruiting
NCT05204251
Evaluation of the Quality of Life in Patients Referred for Transjugular Intrahepatic Portosystemic ShuntNo drug interventionsNot AvailableNot Availablerecruiting
NCT02618798
Hepatic Venous Pressure Gradient and Platelet Activation in Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT01634698
Relative-dose-response Test (RDR) Adaptation for Chronic Liver DiseaseNo drug interventionsdiagnosticNot Availablecompleted
NCT03840928
PatientSpot Formerly Known as ArthritisPowerNo drug interventionsNot AvailableNot Availablerecruiting
NCT02650011
Clinical Features and Natural History of Acute-on-Chronic Liver Failure in Korean Patients With Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablesuspended
NCT04380493
The Use of the Transient Elastography Paediatric Probe, Compared to the M Probe, Indirect Biomarkers and HistologyNo drug interventionsNot AvailableNot Availablecompleted
NCT01393678
Study to Evaluate Efficacy and Safety of PENNEL Capsule in the Patients With Chronic Liver Diseasetreatment3completed
NCT04943978
Prospective Studies on Immunopathogenesis of Liver FibrosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01944878
The Association With Peptic Ulcer Disease and Hepatic Vein Pressure GradientNo drug interventionsNot AvailableNot Availablecompleted
NCT01246388
Non-Invasive Evaluation of Fibrosis and Steatosis in Chronic HepatopathyNo drug interventionsNot AvailableNot Availableunknown_status
NCT04806607
19Gauge Fine Needle Biopsy (FNB) Versus 22Gauge FNB for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB)No drug interventionsdiagnosticNot Availablecompleted
NCT04775056
A Study to Evaluate Vaccines Against COVID-19 in the Real WorldNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02499185
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative PatientsNo drug interventionsdiagnostic4terminated
NCT05224037
Comparative Efficacy of Liver Fibrosis and Steatosis Assessment With Fibroscan and iLivTouchNo drug interventionsdiagnosticNot Availablecompleted
NCT01851252
MBT Versus HVPG in Identifying Responders to Portal Hypertension TherapyNo drug interventionssupportive_care1completed
NCT04015570
Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver Injury With or Without Underlying Chronic Liver Disease.No drug interventionstreatmentNot Availableunknown_status
NCT06318949
Albumin Modifications as Early Biomarkers of Chronic Liver DiseasesNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT05744713
An Observational Study of Patients With Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04246918
Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD PatientsNo drug interventionstreatmentNot Availablecompleted
NCT05532124
Part A: In Patients With Chronic Liver Diseases, LAENNEC (Human Placenta Hydrolysate) is to Assess Safety and Tolerability After the Doses of Doses. Part B: Part A, it is to Determine the Optimal Dose by Evaluating Two Capacity and Placebo Groups.treatment2unknown_status
NCT01433016
Detection of Hepatocellular Carcinoma (HCC) With Octanoate Breath ID Test Compared to MRINo drug interventionsdiagnostic2terminated
NCT04734496
Evaluation of the Mechanisms of Sarcopenia in Chronic Inflammatory Disease: Protocol for a Prospective Cohort StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05849558
Study to Compare the Efficacy & Safety of Ursoplus Capsules vs. UDCA vs. Placebo Among Chronic Liver Disease PatientsNo drug interventionstreatment4recruiting
NCT05044663
Liver and Splenic Stiffness in Predicting Esophageal Varices Needing Treatment in NASH Related Compensated Advanced Chronic Liver Disease.No drug interventionsNot AvailableNot Availablecompleted
NCT02899325
FDGal PET/CT to Detect Hepatocellular CarcinomaNot AvailableNot Availablewithdrawn
NCT06272630
Study to Evaluate the Efficacy and Safety of DWJ1464 in Patients With Chronic Liver DiseaseNo drug interventionstreatment4enrolling_by_invitation
NCT05653830
Observational Clinical Study of the Natural Course and Long-term Prognosis of Patients With Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04526548
A Diagnostic Study on Patients With Drug-induced Liver InjuryNo drug interventionsNot AvailableNot Availableunknown_status
NCT01393665
Study to Evaluate Efficacy, Safety and Tolerability of PENNEL Capsule in the Patients With Chronic Liver DiseaseNo drug interventionstreatment2completed
NCT02715973
Nutritional Assessment Tool and Nutritional Intervention in Childhood Chronic Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT05788627
Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathytreatment4not_yet_recruiting
NCT05397860
Radiofrequency Ablation With Gradual Radiofrequency Energy Increment for Hepatocellular Carcinoma TreatmentNo drug interventionstreatmentNot Availableunknown_status
NCT01337440
Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseasestreatment4unknown_status
NCT04774601
Elastography in Chronic Liver Disease in ChildrenNo drug interventionsNot AvailableNot Availableunknown_status
NCT01747772
Sonoelastography: Ultrasound Method to Measure Liver FibrosisNo drug interventionsdiagnosticNot Availablecompleted
NCT00629668
Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver DiseaseNo drug interventionsbasic_scienceNot Availableunknown_status
NCT01335568
Hepatocyte Matrix Implant Study IndonesiaNo drug interventionstreatment1unknown_status
NCT04775069
Antibody Response to COVID-19 Vaccines in Liver Disease Patientsprevention4completed
NCT05836246
The Development of Quantitative Ultrasound Imaging Software PlatformNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01195181
Different PEG-interferon and Ribavirin Schedules for Chronic Hepatitis C in the Real Clinical Practice.treatment4completed
NCT05118308
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient MeasurementNo drug interventionsdiagnosticNot Availableunknown_status
NCT02086708
Ultrasound Method to Measure Fibrosis of the Liver in ChildrenNo drug interventionsdiagnosticNot Availableterminated
NCT05965843
Intervention, Prognosis and Mechanism of Covid-19 Infection in Patients With Underlying DiseasesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting