BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
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| Glutethimide is a Gamma-aminobutyric acid receptor subunit alpha-1 agonist |
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| 1 | Gamma-aminobutyric acid receptor subunit alpha-1 potentiators | Amobarbital, Aprobarbital, Barbital, Butalbital, Butobarbital, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione, Dihydroquinidine barbiturate, Eszopiclone, Fludiazepam, Heptabarbital, Hexobarbital, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Quinidine barbiturate, Secobarbital, Talbutal, Thiopental, Zaleplon, Zopiclone |
| 2 | Gamma-aminobutyric acid receptor subunit alpha-1 agonists | Ethanol, Etomidate, Isoflurane, Meprobamate, Methoxyflurane, Methyprylon, Progabide, Sevoflurane, Thiamylal, Topiramate, Zolpidem |
| 3 | Gamma-aminobutyric acid receptor subunit alpha-1 antagonists | Amoxapine, Flumazenil, Methohexital, Picrotoxin |
| 4 | Gamma-aminobutyric acid receptor subunit alpha-1 negative modulators | Ginkgo biloba |
| 5 | Gamma-aminobutyric acid receptor subunit alpha-1 activators | Carisoprodol |
| 6 | Gamma-aminobutyric acid receptor subunit alpha-1 modulators | Carisoprodol |
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| Glutethimide is a GABA(A) Receptor positive allosteric modulator |
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| 1 | GABA(A) Receptor positive allosteric modulators | 1,2-Benzodiazepine, Adinazolam, Alprazolam, Bentazepam, Brexanolone, Bromazepam, Brotizolam, Butabarbital, Butalbital, Camazepam, Chlordiazepoxide, Cinazepam, Cinolazepam, Clobazam, Clonazepam, Clorazepic acid, Clotiazepam, Cloxazolam, Delorazepam, Desflurane, Diazepam, Doxefazepam, Estazolam, Eszopiclone, Ethchlorvynol, Ethyl loflazepate, Etizolam, Etomidate, Flumazenil, Flunitrazepam, Flurazepam, Halazepam, Halothane, Isoflurane, Ketazolam, Loprazolam, Lorazepam, Lormetazepam, Medazepam, Meprobamate, Metharbital, Methoxyflurane, Methyprylon, Mexazolam, Midazolam, Nitrazepam, Nordazepam, Oxazepam, Oxazepam acetate, Pentobarbital, Pinazepam, Prazepam, Primidone, Propofol, Quazepam, Remimazolam, Sevoflurane, Stiripentol, Talbutal, Temazepam, Triazolam |
| 2 | GABA(A) Receptor potentiators | Enflurane |
| 3 | GABA(A) Receptor binders | Amoxapine, Memantine |
| 4 | GABA(A) Receptor antagonists | Apalutamide, Lamotrigine, Prasterone, Thiocolchicoside |
| 5 | GABA(A) Receptor agonists | Stiripentol, Taurine |
| 6 | GABA(A) Receptor inducers | Lamotrigine |
| 7 | GABA(A) Receptor inhibitors | Medroxyprogesterone acetate |
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| Glutethimide is a Cholesterol side-chain cleavage enzyme, mitochondrial inhibitor |
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| 1 | Cholesterol side-chain cleavage enzyme, mitochondrial substrates | Cholecalciferol, Ergocalciferol, Stanolone |
| 2 | Cholesterol side-chain cleavage enzyme, mitochondrial inhibitors | Aminoglutethimide, Digitoxin, Digoxin, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate |