Sedative therapy (DBCOND0024331)

Identifiers

Synonyms

Sedation procedure / Sedation (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chloral hydrate	A mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.	No drug targets
Methohexital	An anesthetic used to induce deep sedation.	Gamma-aminobutyric acid receptor subunit alpha-1target
Promethazine	A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.	D(2) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Histamine H2 receptortarget Alpha adrenergic receptortarget P2 Purinoceptorstarget Voltage-gated sodium channel alpha subunittarget Voltage-gated Potassium Channelstarget ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Albumincarrier Calmodulintarget
Propofol	A medication used in general anesthesia and for sedation.	Cytochrome P450 2B6enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A9enzyme Gamma-aminobutyric acid receptor subunit beta-2target Gamma-aminobutyric acid receptor subunit beta-3target Albumincarrier Sodium channel protein type 4 subunit alphatarget Sodium channel protein type 2 subunit alphatarget Fatty-acid amide hydrolase 1enzyme Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1-6enzyme GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter

Clinical Trials

Not Available