Essential Thrombocythemia (ET) (DBCOND0048758)

Identifiers

Synonyms
ET (Essential Thrombocythemia) / Thrombocythemia Essential / Essential Thrombocytosis / Essential Thrombocythaemia / Essential Thrombocythemia / Thrombocythemia, Essential / Primary hemorrhagic thrombocythemia / Primary haemorrhagic thrombocythaemia / Essential (hemorrhagic) thrombocythemia / Essential thrombocythemia (disorder) / Essential thrombocythemia (morphologic abnormality) / Idiopathic thrombocytosis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Busulfan
An alkylating agent used to treat chronic myelogenous leukemia.
Hydroxyurea
An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip).
Pacritinib
A kinase inhibitor used for the treatment of primary and secondary myelofibrosis in adult patients with significantly reduced platelet counts.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04279847
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasmstreatment1recruiting
NCT03212053
Prospective Study of Different Biological Tests (Multiplate, ROTEM) in a Cohort of Patients Followed for Essential Thrombocytemia (ET)No drug interventionsscreeningNot Availablecompleted
NCT06218628
Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibitiontreatment1recruiting
NCT00433862
Molecular Changes and Biomarkers in Chronic Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00586651
Open-Label Study of Oral CEP-701 (Lestaurtinib) in Patients With Polycythemia Vera or Essential Thrombocytosistreatment2completed
NCT02158858
A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosistreatment1 / 2active_not_recruiting
NCT01467661
Long-term Safety of SPD422 in Japanese Adults With Essential Thrombocythaemiatreatment3completed
NCT01816256
Screening for Asymptomatic Portal Vein Thrombosis and Portal Hypertension in Patients With Philadelphia Negative Myeloproliferative NeoplasmsNo drug interventionsscreeningNot Availablecompleted
NCT01352585
Exploratory Multi-centre Trial In Patients With ET Treated With XAGRID®Not AvailableNot Availablecompleted
NCT01214915
Effect of SPD422 on Platelet Lowering and Safety in Japanese Adults With At Risk Essential Thrombocythaemiatreatment3completed
NCT06541249
MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trialtreatment2not_yet_recruiting
NCT01198717
Pediatric Disease Registry in Essential Thrombocythaemia (ET)No drug interventionsNot AvailableNot Availablecompleted
NCT04243122
Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patientsprevention2completed
NCT02577926
The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemiatreatment2active_not_recruiting
NCT03625895
Agrylin Drug Use-Result SurveyNo drug interventionsNot AvailableNot Availablecompleted
NCT06514807
A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patientstreatment3recruiting
NCT01230775
Anagrelide Retard vs. Placebo: Efficacy and Safety in "At-risk" Patients With Essential Thrombocythaemiaprevention3completed
NCT00413634
The Pharmacokinetics of Anagrelide in Elderly and Young Patients With Essential Thrombocythaemia (ET)treatment2completed
NCT01065038
Anagrelide vs. Hydroxyurea - Efficacy and Tolerability Study in Patients With Essential ThrombocythaemiaNot Available3completed
NCT05031897
Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Undergo a Hematopoietic Stem Cell TransplantNo drug interventionstreatment2recruiting
NCT06378437
A Study of GLB-001 in Patients With Myeloid MalignanciesNo drug interventionstreatment1recruiting
NCT06456346
Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)treatment3recruiting
NCT06150157
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative NeoplasmsNo drug interventionstreatment1recruiting
NCT06079879
A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)treatment3recruiting
NCT00489203
Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancersupportive_care2completed
NCT00890747
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapytreatment1completed
NCT00715247
Polycythemia Vera, Myelofibrosis and Essential Thrombocythemia: Identification of PV, MF & ET GenesNo drug interventionsNot AvailableNot Availablecompleted
NCT02897297
Myeloproliferative Neoplastic Diseases Observatory From BrestNo drug interventionsNot AvailableNot Availablerecruiting
NCT01998828
Safety and Efficacy of Momelotinib in Subjects With Polycythemia Vera or Essential Thrombocythemiatreatment2terminated
NCT04644211
Ruxolitinib in Thrombocythemia and Polycythemia Veratreatment2recruiting
NCT05482971
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ETtreatment2recruiting
NCT03745378
Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study)No drug interventionsNot AvailableNot Availablecompleted
NCT04254978
Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)treatment2completed
NCT05025488
Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasmtreatment1recruiting
NCT02962388
The Ruxolitinib Versus Best Available Therapy Trial in Patients With High Risk ET in Second Linetreatment2 / 3terminated
NCT04051307
Dual Vaccine Trial in Myeloproliferative NeoplasmsNo drug interventionstreatment1 / 2completed
NCT02076815
Anagrelide Retard in Essential Thrombocythemiatreatment3completed
NCT00025415
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunctiontreatment1completed
NCT01787552
A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MFtreatment1 / 2completed
NCT03116542
18F-FLT (PET/CT) in Prefibrotic/Early Primary Myelofibrosis and Essential ThrombocythemiaNo drug interventionsdiagnosticNot Availableunknown_status
NCT03878199
Testing the Effect of Taking Ruxolitinib and CPX-351 in Combination for the Treatment of Advanced Phase Myeloproliferative Neoplasmstreatment1 / 2recruiting
NCT00666549
Research Tissue BankNo drug interventionsNot AvailableNot Availablecompleted
NCT03907436
The NUTRIENT Trial (NUTRitional Intervention Among myEloproliferative Neoplasms): Feasibility PhaseNo drug interventionstreatmentNot Availablecompleted
NCT01384513
A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignanciestreatment2completed
NCT00397813
Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorderstreatment2completed
NCT04285086
Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerancetreatment3active_not_recruiting
NCT06063486
Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative NeoplasmsNo drug interventionstreatment2recruiting
NCT03862157
Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemiatreatment1 / 2active_not_recruiting
NCT05123365
An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasmstreatment1 / 2recruiting
NCT01520220
Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasmstreatment1completed
NCT02556931
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignanciestreatment2completed
NCT05882773
Asian Myeloproliferative Neoplasm (MPN) RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT06371573
Ultrasound Examination for Spleen Volume Evaluation in Myeloproliferative NeoplasmsNo drug interventionsNot AvailableNot Availablecompleted
NCT03869476
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.No drug interventionsdiagnosticNot Availablerecruiting
NCT05198960
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasmsprevention3recruiting
NCT00588991
Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorderstreatment1active_not_recruiting
NCT00227591
Lenalidomide and Prednisone in Treating Patients With Myelofibrosistreatment2completed
NCT01199562
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantNot AvailableNot Availablecompleted
NCT00866762
A Study of the Efficacy of MK-0683 in Patients With Polycythaemia Vera and Essential Thrombocythaemiatreatment2unknown_status
NCT06552429
Peginterferon α-2b Injection for Hydroxyurea Resistant or Intolerant ETNo drug interventionstreatment2not_yet_recruiting
NCT00445744
Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic SyndrometreatmentNot Availablecompleted
NCT03566446
CALR Exon 9 Mutant Peptide Vaccine to Patients With CALR-mutant Myeloproliferative NeoplasmsNo drug interventionstreatment1completed
NCT03289910
Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemiatreatment2active_not_recruiting
NCT00745550
A Phase 1/2 Study of Oral SB1518 in Subjects With Chronic Idiopathic Myelofibrosistreatment1 / 2completed
NCT02760238
Myeloproliferative Neoplasms (MPNs) Patient RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT00047190
Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasiatreatment2completed
NCT00668421
CEP-701 (Lestaurtinib) in Myelofibrosistreatment1 / 2unknown_status
NCT02823184
Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative NeoplasmsNo drug interventionsNot AvailableNot Availablecompleted
NCT04282187
Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasmstreatment2recruiting
NCT03232177
Anagre Cap. in Patients With High-Risk Essential ThrombocythemiaNo drug interventionstreatment4completed
NCT01192347
French Observational Xagrid (FOX) Study In Adult Patients With Essential ThrombocythemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00357305
Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorderstreatment1completed
NCT00089011
Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancertreatment2completed
NCT00112593
Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without CancertreatmentNot Availablecompleted
NCT01588015
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell TransplantNo drug interventionssupportive_care1completed
NCT00718159
Study of LY573636-sodium in Essential Thrombocythemia and Acute Myeloid Leukemiatreatment1completed
NCT03121599
18F-FLT (PET/CT) in Pediatrics With Myeloproliferative NeoplasmsNo drug interventionsdiagnosticNot Availableterminated
NCT06361641
Functional and Phenotypic Characterization of Monocytes in Myeloproliferative SyndromesNo drug interventionsdiagnosticNot Availablerecruiting
NCT04262141
IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)treatment2active_not_recruiting
NCT00039416
Imatinib Mesylate in Treating Patients With Myelofibrosistreatment2completed
NCT01831635
Myeloproliferative Neoplasms: an In-depth Case-control StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01387763
A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasmstreatment3completed
NCT01970930
Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02663648
Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00052520
Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantationtreatment1 / 2completed
NCT02611973
Hydroxyurea Versus Aspirin and Hydroxyurea in Essential Thrombocythemiatreatment3unknown_status
NCT01243073
Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Veratreatment2completed
NCT01053494
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for CancerNo drug interventionssupportive_careNot Availablecompleted
NCT02407080
Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemiatreatment1completed
NCT04942080
Interest of CALR Allele Burden in Diagnosis and Follow-up of Patients With CALR Mutated Myeloproliferative Syndromes (CALRSUIVI)No drug interventionsotherNot Availablerecruiting
NCT00666289
Familial Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00665067
Correlative Biomarker Study in Patients With Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT02129101
Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignanciestreatment1completed
NCT02311569
Sympathicomimetic Agonist in Patients With Myeloproliferative Neoplasms With JAK2-mutationtreatment2completed
NCT01014546
Arsenic Trioxide With or Without Ascorbic Acid in Treating Patients With Myelofibrosistreatment1terminated
NCT02124746
Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemiatreatment2completed
NCT02893410
Drug Observance and Side Effects of Cytoreductive Drugs in PV and ET PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00381550
3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemiatreatment2completed
NCT03972943
CPAP in Treating Obstructive Sleep Apnea in Patients With Polycythemia Vera or Essential ThrombocythemiaNo drug interventionstreatment0terminated
NCT05223920
Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005)treatment2completed
NCT06351631
A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)treatment3recruiting
NCT02912884
Treatment of Polycythaemia Vera and Essential Thrombocythaemia: Influence on the Clot StructureNo drug interventionsNot AvailableNot Availablecompleted
NCT00522574
A Safety Study of XL019 in Adults With Myelofibrosistreatment1terminated
NCT04081220
Hematology, IMG-7289, LSD1 (Lysine-Specific Demethylase 1) Inhibitor, Essential Thrombocythemia (ET), Ph 2treatment2active_not_recruiting
NCT01134120
A Study in Myeloproliferative Disorderstreatment1completed
NCT00567502
Safety and Pregnancy Outcomes in Thrombocythemia Patients Exposed to XAGRID® (Anagrelide Hydrochloride) Compared to Other TreatmentsNo drug interventionsNot AvailableNot Availablecompleted
NCT01816022
Myeloproliferative Neoplasms and Bone StructureNo drug interventionsNot AvailableNot Availableunknown_status