Secondary Progressive Multiple Sclerosis (SPMS) (DBCOND0049960)

Identifiers

Synonyms
Secondary-progressive Multiple Sclerosis (SPMS) / Secondary Multiple Sclerosis, Progressive / Multiple Sclerosis, Secondary Progressive / Secondary-progressive Multiple Sclerosis / Secondary Progressive MS (SPMS) / Secondary Progressive MS / Secondary Progressive Multiple Sclerosis / Secondary progressive multiple sclerosis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Alemtuzumab
A monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.
Interferon beta-1b
A form of recombinant human interferon used to slow the progression of relapsing multiple sclerosis and to reduce the frequency of clinical symptoms.
Mitoxantrone
A chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
Natalizumab
A monoclonal anti-integrin antibody used to treat Crohn's disease or multiple sclerosis.
Peginterferon beta-1a
An interferon beta used to treat relapsing forms of multiple sclerosis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05177523
Imaging the Interplay Between Axonal Damage and Repair in Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT06436131
The Effects of In-phase Bilateral Exercise in People with Progressive Multiple SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT02305264
Imaging of Intracerebral Inflammation in MSdiagnosticNot Availablecompleted
NCT06526364
Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05168384
Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple SclerosisNo drug interventionstreatment1 / 2recruiting
NCT05357833
Novel Imaging Markers in SPMSdiagnostic0completed
NCT05663853
An Observational Biomarker Study in Multiple Sclerosis (MS) PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00888277
Bayer/Cognitive Assessments With Multiple Sclerosis SubjectsNo drug interventionsNot AvailableNot Availablecompleted
NCT01433497
Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosistreatment3completed
NCT03653585
Cortical Lesions in Patients With Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT02308137
Domperidone in Secondary Progressive Multiple Sclerosis (SPMS)treatment2completed
NCT01982942
Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosistreatment2completed
NCT06276634
Intermittent Hypoxia in Persons With Multiple SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT06516458
Development of Camera Based Gait Quality Measure for Persons With Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05013463
Hydroxychloroquine and Indapamide in SPMStreatment2unknown_status
NCT04918225
Motor Asymmetry in Progressive Multiple Sclerosis PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06390930
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MSNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06413602
The Synergistic Effects of AIH and FES in Persons With MSNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02506751
Open-label Study of Liothyronine in MStreatment1completed
NCT04260711
Discontinuing Disease-modifying Therapies in Stable Relapsing - Onset Multiple Sclerosis (DOT-MS).treatmentNot Availableunknown_status
NCT00468611
Efficacy and Safety of MBP8298 in Subjects With Secondary Progressive Multiple Sclerosistreatment3terminated
NCT06138132
A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosistreatment1recruiting
NCT02430532
BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosistreatment3terminated
NCT05122559
Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosistreatment2recruiting
NCT05204459
MS-ResearchBiomarkerSNo drug interventionsNot AvailableNot Availablerecruiting
NCT02273635
Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MStreatment1 / 2unknown_status
NCT04993274
Sensitivity of Motor Assessment in MS - a Prospective Cohort StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05385731
MUSCLE - Nordic Walking in MUltiple SCLErosisNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06384976
A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple SclerosisNo drug interventionstreatment2not_yet_recruiting
NCT00587691
Dose-Escalation Study of T Cell Vaccine in Multiple SclerosisNo drug interventionstreatment1 / 2completed
NCT05961644
Cladribine vs Placebo for Non-active Progressive Multiple Sclerosis (CLASP-MS).treatment2 / 3recruiting
NCT04211740
Phase II Clinical Trial of OCH-NCNP1No drug interventionstreatment2completed
NCT02988401
Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosistreatment1 / 2completed
NCT05496881
Exercise Effects in Multiple SclerosisNo drug interventionssupportive_careNot Availablerecruiting
NCT06588387
A Real-world Study to Assess the Use of Siponimod in Spain to Treat Patients With Secondary Progressive Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT02549703
Mitochondrial Dysfunction and Disease ProgressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02266121
Improving Cognitive Aptitudes With tDCS in Patients With Multiple SclerosisNo drug interventionstreatmentNot Availableterminated
NCT06526000
Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 TherapiesNo drug interventionsNot AvailableNot Availablecompleted
NCT06395909
A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT04047628
Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)treatment3recruiting
NCT03896217
Simvastatin in Secondary Progressive Multiple Sclerosistreatment2completed
NCT03783416
SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple SclerosisNo drug interventionsother1recruiting
NCT03493841
Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosistreatment1completed
NCT02228213
Safety and Efficacy Study of MIS416 to Treat Secondary Progressive Multiple SclerosisNo drug interventionstreatment2completed
NCT02207075
Measuring Active Microglia in Progressive Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT01950234
ACTH in Progressive Forms of MStreatment2terminated
NCT01910259
MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trialtreatment2completed
NCT01228396
AIMSPRO in the Treatment of Bladder Dysfunction in Secondary Progressive Multiple Sclerosistreatment2unknown_status
NCT01191996
Safety Study of an Immunomodulating Microparticle to Treat Progressive Multiple SclerosisNo drug interventionstreatment1 / 2completed
NCT00647348
Investigation of Simvastatin in Secondary Progressive Multiple Sclerosistreatment2completed
NCT00146159
Study Evaluating Mitoxantrone in Multiple Sclerosistreatment3terminated
NCT06360861
Evaluate the Safety and Feasibility of Allogeneic Mesenchymal Stem Cells in Patients With Multiple SclerosisNo drug interventionstreatment1completed
NCT04925557
Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosisdiagnostic2 / 3completed
NCT06372145
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.treatment3recruiting
NCT05826028
Mayzent (Siponimod) Onboarding of Secondary Progressive Multiple Sclerosis (SPMS) Patients With MSGoNo drug interventionsNot AvailableNot Availablecompleted
NCT05349474
Metformin Treatment in Progressive Multiple Sclerosistreatment0recruiting
NCT04239664
Acceptance Based Telephone Support When Transitioning to SPMSNo drug interventionssupportive_careNot Availablecompleted
NCT04688788
Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosistreatment3active_not_recruiting
NCT04634994
Novel Assessment of Synaptic Density in Progressive MSNo drug interventionsdiagnostic0unknown_status
NCT05029609
Phase 1b Multiple Ascending Dose Study of Foralumab in Primary and Secondary Progressive MStreatment1withdrawn
NCT06292923
A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patientstreatment2recruiting
NCT03315923
Comparison of Clinical Effects of Rituximab and Glatiramer Acetate in Secondary Progressive Multiple Sclerosis Patientstreatment2 / 3completed
NCT03283826
Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple SclerosisNo drug interventionstreatment1 / 2terminated
NCT02253264
A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patientstreatment1completed
NCT02495766
Autologous Mesenchymal Stromal Cells for Multiple Sclerosistreatment1 / 2completed
NCT01737372
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT01684761
Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple SclerosisNo drug interventionstreatment2completed
NCT01665144
Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)treatment3completed
NCT01647321
Functional Electrical Stimulation for Individuals With Secondary Progressive Multiple SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT01416181
A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosistreatment3terminated
NCT01181089
Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the Cerebrospinal Fluid (CSF)and Safety in Subjects With Secondary Progressive Multiple Sclerosis (SPMS)treatment1 / 2withdrawn
NCT01044576
Patient Research Cohort: Rapidly Evolving Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00869726
A Study for Patients With Secondary Progressive Multiple Sclerosistreatment2 / 3completed
NCT00870155
A Study for Patients With Multiple Sclerosistreatment2 / 3terminated
NCT00559702
Safety Study of Natalizumab to Treat Multiple Sclerosis (MS)treatment1completed
NCT03282760
Safety Study of Human Neural Stem Cells Injections for Secondary Progressive Multiple Sclerosis PatientsNo drug interventionstreatment1completed
NCT01466114
Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognitiontreatment2unknown_status
NCT04792567
Exploring the Immune Response to SARS-CoV-2 modRNA Vaccines in Patients With Secondary Progressive Multiple Sclerosis (AMA-VACC)treatment4completed
NCT05327322
Functional Outcomes From Diets in Multiple SclerosisNo drug interventionsotherNot Availablerecruiting
NCT04411641
Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168)treatment3active_not_recruiting
NCT03471338
Neuropsychological Management of Multiple Sclerosis: Benefits of a Computerised Semi-autonomous At-home Cognitive Rehabilitation ProgrammeNo drug interventionsotherNot Availableactive_not_recruiting
NCT02296346
Open-Label Study to Evaluate the Efficacy of ECP in Secondary Progressive Multiple SclerosisNo drug interventionstreatmentNot Availableterminated
NCT02330965
Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT02208050
A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MStreatment4completed
NCT01917019
A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosistreatment3completed
NCT01077466
Natalizumab Treatment of Progressive Multiple Sclerosistreatment2completed
NCT00813969
Autologous Mesenchymal Stem Cell (MSC) Transplantation in MSNo drug interventionstreatment1completed
NCT00257855
A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosistreatment2completed
NCT05893225
Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegenerationtreatment2recruiting
NCT03935529
Behavioural Activation for Low Mood in Multiple SclerosisNo drug interventionssupportive_careNot Availablecompleted
NCT06599307
The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosissupportive_care2recruiting
NCT01235455
Portuguese Observational Survey to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon by Using Elements of the BetaPlus Program - Nurse Support, Auto-injectorsNot AvailableNot Availablecompleted
NCT03696485
Study to Assess the Safety and Efficacy of an IT Administration of SCM-010 in SPMSNo drug interventionstreatment1 / 2withdrawn
NCT03387670
Multiple Sclerosis-Simvastatin Trial 2treatment3unknown_status
NCT04593927
Long Term Special Drug Use-results Surveillance for Mayzent in SPMS PatientsNot AvailableNot Availablecompleted
NCT01233245
BetaPlus Survey - Observational Study to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon® by Using Elements of the BetaPlus ProgramNot AvailableNot Availablecompleted
NCT01804647
Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01848327
Caprylic Triglyceride for Treatment of Cognitive Impairments in Multiple SclerosisNo drug interventionstreatmentNot Availablecompleted