Thyroid Eye Disease (DBCOND0051704)

Identifiers

Synonyms
Thyroid Eye Disease (TED) / Graves' Ophthalmopathy (GO) / Thyroid Related Eye Disease / Thyroid-Related Eye Disease / Endocrine ophthalmopathy / Graves' Ophthalmopathy / Thyroid Eye Disease, TED / Graves Ophthalmopathy / Thyroid eye disease / Thyroid eye disease (disorder) / Endocrine exophthalmos / Exophthalmos endocrine

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Prednisone
A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
Teprotumumab
A fully human monoclonal antibody directed against insulin-like growth factor-1 receptor for the treatment of thyroid eye disease.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03922321
Study of RVT-1401 for the Treatment of Patients With Moderate to Severe Active Graves' Ophthalmopathy (GO)No drug interventionstreatment2completed
NCT01056419
The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathytreatment4unknown_status
NCT02721992
Graves' Orbitopathy and HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02059655
Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)treatment4completed
NCT00430547
Thyroid-Associated Ophthalmopathy Subtypes and Orbital AntibodiestreatmentNot Availablecompleted
NCT00697528
Color Doppler Imaging of Orbital Venous Flow in Grave's OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT01969019
A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathytreatment4unknown_status
NCT00174057
The Role of TSH Receptor, PPAR-r, IGF-1R, IGF and Cytokines in Different Stages of Graves'OphthalmopathyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02290704
Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal PeopleNo drug interventionsNot AvailableNot Availableunknown_status
NCT03426696
Psychological Status and Related Factors of Thyroid Related Eye DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03938545
ASCEND GO-2: Study of RVT-1401 for the Treatment of Participants With Active, Moderate to Severe Graves' Ophthalmopathy ( GO )No drug interventionstreatment2terminated
NCT01297699
Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease)treatment3completed
NCT06226545
A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye DiseaseNo drug interventionstreatment2active_not_recruiting
NCT06588764
Modified Orbital Decompression in the Treatment of Moderate-to-severe Grave's OphthalmopathyNo drug interventionstreatmentNot Availablerecruiting
NCT01999790
Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's OrbitopathyNo drug interventionstreatmentNot Availableunknown_status
NCT03122847
Glucocorticoids and Bone in Graves' OphthalmopathyNot AvailableNot Availableactive_not_recruiting
NCT05775185
Therapeutic Efficacy of Orbital Radiotherapy in Patients With Graves' OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT04598815
Sirolimus for Graves' Orbitopathy (GO)treatment2not_yet_recruiting
NCT05793359
Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' OrbitopathyNot AvailableNot Availablecompleted
NCT02339142
Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Diseaseprevention4unknown_status
NCT01379196
Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathytreatment1 / 2withdrawn
NCT03324022
Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT02203682
Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathytreatment2unknown_status
NCT01727973
Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathytreatment1 / 2completed
NCT03590080
Impact of Intravenous Methylprednisolone Treatment on Blood PressureNot AvailableNot Availablecompleted
NCT06112340
A Phase 2b Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)treatment2 / 3recruiting
NCT05532072
Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.treatment0unknown_status
NCT01272414
Use of Botox in the Management of Thyroid Related Upper Eyelid Retractiontreatment4withdrawn
NCT01893450
Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune TreatmenttreatmentNot Availableterminated
NCT01114503
A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Diseasetreatment2terminated
NCT03535090
Coagulation After Intravenous Methylprednisolone AdministrationNot AvailableNot Availablecompleted
NCT03278964
Analysis Between the Results of Two Surgical Techniques of Orbital Decompression in Patients With Graves OrbitopathyNo drug interventionstreatmentNot Availablecompleted
NCT05126147
Hydroxychloroquine in Mild Graves' Orbitopathytreatment4recruiting
NCT04488406
Genetics and Epigenetics of Graves' OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT00348413
Thyroid Treatment TrialNo drug interventionstreatmentNot Availablecompleted
NCT05345119
Sirolimus in Graves' OrbitopathyNot AvailableNot Availablecompleted
NCT03498417
Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT04876534
Tocilizumab in Active Moderate-severe Graves' Orbitopathytreatment2unknown_status
NCT03195296
T and B Cells in Graves' OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05276063
A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)treatment2 / 3active_not_recruiting
NCT04391439
Heart Rhythm After Intravenous Methylprednisolone AdministrationNot AvailableNot Availablecompleted
NCT03667157
Liver Function After Intravenous Methylprednisolone AdministrationNo drug interventionssupportive_care4completed
NCT03131726
Treatment of Graves´Ophthalmopathy With Simvastatin (GO-S)treatment3recruiting
NCT05678374
Exploring Immunological Markers Associated With Mental Fatigue in Graves' DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06275373
The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid DysfunctionNot AvailableNot Availablerecruiting
NCT03708627
Bimatoprost as a Treatment for Graves' Orbitopathytreatment0recruiting
NCT03066076
Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathytreatment3unknown_status
NCT04927468
Supramaximal Rectus Recession for Strabismus in Grave's OphthalmopathyNo drug interventionstreatmentNot Availableunknown_status
NCT04704414
Exophthalmometry With 3D Face ScannersNo drug interventionsdiagnosticNot Availableunknown_status
NCT06510114
A Randomized Clinical Trial of Intravenous Methylprednisolone With 2 Protocols in Patients With Graves Orbitopathytreatment4not_yet_recruiting
NCT06413043
Study on Efficacy of Add on Selenium in Mild-to-moderate Graves OphthalmopathytreatmentNot Availablenot_yet_recruiting
NCT06569758
A Study of GensSci098 in Subjects With Active Thyroid Eye DiseaseNo drug interventionstreatment1not_yet_recruiting
NCT05002998
TEPEZZA® (Teprotumumab-trbw) Post-Marketing Requirement Studytreatment4active_not_recruiting
NCT05517421
Study to Assess Batoclimab in Participants With Active Thyroid Eye Diseasetreatment3recruiting
NCT05517447
Extension Study to Assess Batoclimab in Participants With Thyroid Eye Diseasetreatment3recruiting
NCT05987423
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Diseasetreatment3recruiting
NCT06088979
A Study to Investigate Efficacy and Safety of TOUR006 in Participants 18 to 80 Years of Age With Thyroid Eye DiseaseNo drug interventionstreatment2recruiting
NCT06401044
A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye DiseaseNo drug interventionstreatment1recruiting
NCT06557850
A Trial Investigating Lu AG22515 in Adult Participants With Moderate-to-Severe Thyroid Eye DiseaseNo drug interventionstreatment1recruiting
NCT06248619
A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Diseasetreatment3recruiting
NCT06307613
A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults with Thyroid Eye DiseaseNo drug interventionstreatment3recruiting
NCT06307626
A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults with Thyroid Eye Disease.No drug interventionstreatment3recruiting
NCT06625398
An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants with Chronic Thyroid Eye Disease (TED)No drug interventionstreatment3recruiting
NCT06625411
An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants with Active Thyroid Eye Disease (TED)No drug interventionstreatment3recruiting
NCT05176639
A Safety, Tolerability and Efficacy Study of Veligrotug (VRDN 001) in Healthy Volunteers and Participants with Thyroid Eye Disease (TED) ( THRIVE )treatment3active_not_recruiting
NCT05683496
Efficacy and Safety of Lonigutamab in Subjects with Thyroid Eye Disease (TED)treatment1 / 2recruiting
NCT06021054
An Efficacy, Safety, and Tolerability Study of Veligrotug (VRDN-001), in Participants with Chronic Thyroid Eye Disease (TED) (THRIVE-2)treatment3active_not_recruiting
NCT06525506
A Study of IBI311 in Subjects With Inactive or Active Thyroid Eye DiseaseNo drug interventionstreatment2recruiting
NCT05776121
Study of ZB001 in Chinese Patients With Thyroid Eye DiseaseNo drug interventionstreatment1active_not_recruiting
NCT05795621
A Study of IBI311 in Subjects With Active Thyroid Eye DiseaseNo drug interventionstreatment2 / 3completed
NCT04359979
Tamsulosin for Thyroid Lid RetractiontreatmentNot Availableunknown_status
NCT01738243
Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Diseasetreatment4terminated
NCT05012033
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic SettingNo drug interventionsNot AvailableNot Availablerecruiting
NCT05731154
Development of an AI Solution to Evaluate Clinical Activity of TAO Using Periocular Images Taken by Smartphones in Patients With Thyroid DysfunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT06384547
A Randomized, Active Controlled, Safety and Tolerability Study of VRDN-001 in Participants With Thyroid Eye Disease (TED)No drug interventionstreatment3recruiting
NCT03461211
Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Studytreatment3completed
NCT05524571
Study to Assess Batoclimab in Participants With Active Thyroid Eye Diseasetreatment3recruiting
NCT03103607
Disappearance of Graves' OrbitopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05331300
A Study to Evaluate the Safety, Preliminary Efficacy, and Pharmacokinetic Properties of LASN01 in Healthy Subjects and in Patients With Pulmonary Fibrosis or Thyroid Eye DiseaseNo drug interventionstreatment1 / 2active_not_recruiting
NCT06179875
An Open-label Study for Participants Who Are Non-responders at the End of Treatment Assessment on the VRDN-001-101 and VRDN-001-301 Pivotal StudiesNo drug interventionstreatment3recruiting
NCT01927406
The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.prevention4withdrawn
NCT04311606
Anti-VEGF Therapy for Acute Thyroid Eye Diseasetreatment2recruiting
NCT02845336
Celecoxib for Thyroid Eye Diseasetreatment2terminated
NCT06367517
Tocilizumab in Corticosteroid-Resistant Graves' Orbitopathy (Thyroid Eye Disease)Not AvailableNot Availablerecruiting
NCT04976816
Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye DiseaseNo drug interventionstreatment2 / 3completed
NCT04737330
A Study of the Efficacy and Safety of Secukinumab 300 mg in Patients With Thyroid Eye Disease (TED)treatment3terminated
NCT02316691
B-cell Depletion Therapy With Rituximab for Thyroid Eye DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT05627401
Customized Multiple Orbital Wall Decompression for Sight-threatening Graves's OphthalmopathyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04096612
The Therapeutic Effect of Dysthyroid Optic NeuropathyNo drug interventionsotherNot Availableunknown_status
NCT06359795
Exploring the Value of 18F-AlF-FAPI PET/CT in Assessing the Activity of Thyroid Eye DiseaseNo drug interventionsdiagnosticNot Availablerecruiting
NCT02393183
The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED)treatment2 / 3withdrawn
NCT06106828
A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Participants With Thyroid Eye Disease (SatraGO-2)treatment3recruiting
NCT06389578
A Study of TEPEZZA® Treatment in Participants With Thyroid Eye Diseasetreatment1completed
NCT04433936
Corneal Tomographic Parameters in TGDNo drug interventionsNot AvailableNot Availablecompleted
NCT06467435
Evaluation of K9 in Subjects With Thyroid Eye Disease (TED)treatment1recruiting
NCT04583735
A Study Evaluating TEPEZZA® Treatment in Patients With Chronic (Inactive) Thyroid Eye Diseasetreatment4completed
NCT05241626
AS-OCT of the Cornea in Thyroid DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT01798966
Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye DiseaseNo drug interventionsdiagnosticNot Availablecompleted
NCT04040894
Expanded Access Protocol of Teprotumumab (HZN-001) for Patients With Active Thyroid Eye DiseaseNot AvailableNot Availableapproved_for_marketing
NCT03298867
Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Studytreatment3completed
NCT06235372
Evaluation of the Corneal Endothelial Cell Layer by Specular Microscopy in Patients With Thyroid Eye DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02422368
The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Diseasetreatment2 / 3withdrawn
NCT00954057
Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED)No drug interventionstreatment2completed
NCT06126783
A Multicenter, Open-label Extension Study Evaluating the Efficacy and Safety of IBI311 in Subjects With Thyroid Eye DiseaseNo drug interventionstreatment3recruiting