Prosthetic Joint Infections (DBCOND0059942)

Identifiers

Synonyms
Prosthetic-joint Infection / Infections Joint Prosthetic / Prosthetic Joint Infection / Prosthetic joint infection (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ceftriaxone
A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.
Rifampin
An antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06383611
Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange ArthroplastyNo drug interventionsNot AvailableNot Availableavailable
NCT05642013
SHort Interval Full Two-stage Implant ExchangeNo drug interventionsotherNot Availablerecruiting
NCT05399186
Arthroplasty and Modifiable Risk FactorsNo drug interventionspreventionNot Availablecompleted
NCT05434260
Surgiphor vs Saline JointsNo drug interventionspreventionNot Availableenrolling_by_invitation
NCT06427772
Incidence of Early Infection After Bipolar Hemiarthroplasty and Its Associated Factors in Fracture Neck of FemurNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05551572
Physiopathology of Prosthetic Joint InfectionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05530551
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OANo drug interventionspreventionNot Availablerecruiting
NCT05265598
Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05676411
Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium AcnesNo drug interventionsprevention4withdrawn
NCT05919888
SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder ArthroplastyNo drug interventionsprevention4completed
NCT05440032
LE as a Marker for Periprosthetic Joint InfectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT06293352
Real-component vs All-cement Articulating Spacers for Periprosthetic Knee InfectionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05607030
A Second Trial of the Abbreviated Protocol Two-Stage ExchangeNo drug interventionstreatment2active_not_recruiting
NCT05530174
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a FractureNo drug interventionspreventionNot Availablerecruiting
NCT06172010
Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint InfectionNo drug interventionstreatment4recruiting
NCT06023238
Knee Prosthetic Joint Infection Antibiotic ElutionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03769337
New Markers for Diagnosis of Prosthetic InfectionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01957228
Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic StrategyNo drug interventionsdiagnosticNot Availablecompleted
NCT01705496
[124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip JointNo drug interventionsdiagnostic2terminated
NCT06451224
Egyptian Arthroplasty Surgeons' Antibiotics Usage AwarenessNo drug interventionsNot AvailableNot Availablerecruiting
NCT05604157
Ancef Dosage in Knee Arthroplasty : Tourniquet Clinical TrialNo drug interventionspreventionNot Availablerecruiting
NCT04620395
Percutaneous Punch Biopsy for Diagnosis of Septic and Aseptic Prosthetic Joint FailureNo drug interventionsdiagnosticNot Availableunknown_status
NCT05902221
Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint InfectionsNo drug interventionstreatment3not_yet_recruiting
NCT04297592
Antibiotic Prophylaxis in High-Risk Arthroplasty PatientsNo drug interventionsprevention4enrolling_by_invitation
NCT04724603
Phage Safety Retrospective Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02805803
Quality of Life Assessment in Patients Undergoing Prolonged Suppressive Antibiotherapy for Prosthetic Joint Infection.No drug interventionshealth_services_researchNot Availablerecruiting
NCT03717090
Rapid Diagnosis of Prosthetic Joint Infection by Matrix-assisted Laser DesorptionNo drug interventionsNot AvailableNot Availablecompleted
NCT04042233
Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a ProtocolNo drug interventionsprevention4completed
NCT06062251
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint InfectionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02801253
Cohort of Prosthetic Joint InfectionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05211011
Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infectiontreatment4unknown_status
NCT04938193
68Ga-citrate PET/CT for the Diagnosis of Chronic Prosthetic Hip or Knee InfectionNo drug interventionsdiagnostic2recruiting
NCT00829556
Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint ReplacementNo drug interventionspreventionNot Availablecompleted
NCT04662632
Abbreviated Protocol for Two-Stage ExchangeNo drug interventionstreatment2completed
NCT03263832
Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT05060952
Calprotectin in Chronic Prosthetic Joint InfectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03200470
The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01373099
Study of Antibiotic Spacer Design to Treat Infection After Hip ReplacementNo drug interventionstreatmentNot Availablecompleted
NCT04858217
Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial MarkersNo drug interventionsNot AvailableNot Availablerecruiting
NCT05269134
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)No drug interventionstreatment2withdrawn
NCT03694925
Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee ArthroplastyNo drug interventionsNot AvailableNot Availablecompleted
NCT03378427
Tedizolid Prolonged Treatment for Prosthetic Joint InfectionsNo drug interventionstreatmentNot Availablecompleted
NCT04618276
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)No drug interventionsotherNot Availablecompleted
NCT03848091
Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03260010
Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint InfectionNo drug interventionstreatment4unknown_status
NCT05247281
NGS vs Culture Outcomes for Treatment of PJINo drug interventionsdiagnosticNot Availableenrolling_by_invitation
NCT04787250
Bacteriophage Therapy in Patients With Prosthetic Joint InfectionsNo drug interventionstreatment1 / 2withdrawn
NCT05000723
Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals LeuvenNo drug interventionsNot AvailableNot Availablerecruiting
NCT03826108
ARTHR-IS (Arthroplasties' Infections Due to Staphylococcus Aureus)No drug interventionsNot AvailableNot Availableunknown_status
NCT04067843
Effect of Photodynamic Treatment on Skin Microbiome. Single Center StudyNo drug interventionsotherNot Availablecompleted
NCT05269121
Bacteriophage Therapy in First Time Chronic Prosthetic Joint InfectionsNo drug interventionstreatment1 / 2withdrawn
NCT04661345
Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint InfectionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03426761
Dalbavancin For The Treatment of Gram Positive Osteoarticular InfectionsNo drug interventionstreatment4completed
NCT03721328
Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint IrrigationNo drug interventionstreatment2completed
NCT04650607
Phage Safety Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03784807
New Strategies for Biofilm Related InfectionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04390607
Leukocyte Esterase Sensor TestNo drug interventionsNot AvailableNot Availableunknown_status
NCT03307109
Quality of Life in Patients Having a Prosthetic Joint InfectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT04946500
Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA)No drug interventionsNot AvailableNot Availableunknown_status
NCT04763759
Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint InfectionsNo drug interventionstreatment1completed
NCT04762706
Measuring Distress in Prosthetic Joint Infection Using a Standardized Metric: CRUTCH Pathway Pilot.No drug interventionssupportive_careNot Availablecompleted
NCT02413034
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection CulturesNo drug interventionspreventionNot Availablecompleted
NCT04488458
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint InfectionsNo drug interventionsdiagnosticNot Availableunknown_status
NCT02806063
Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint InfectionNo drug interventionshealth_services_researchNot Availablecompleted
NCT03806166
Short or Long Antibiotic Regimes in OrthopaedicsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03714165
Alpha Defensin and 16S rRNA Gene in Diagnosis of PJINo drug interventionsNot AvailableNot Availableunknown_status
NCT03612076
Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT04294862
Tissue Distribution, Pharmacokinetics, Safety, and Tolerability After a Single Dose of TNP-2092 in Participants Undergoing Primary Total Hip or Knee ArthroplastyNo drug interventionsother1completed
NCT04056780
Integrated Microfluidic Systems for Diagnosis of Periprosthetic Joint InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT05169229
Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.No drug interventionstreatment2 / 3recruiting
NCT04409392
Staphylococcus Lugdunensis Prosthetic Joint InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT03473392
One-stage Exchange Arthroplasty for Chronic Prosthetic Joint InfectionsNo drug interventionsNot AvailableNot Availablecompleted
NCT05676801
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)No drug interventionsprevention0recruiting
NCT04746001
Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT05239312
Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From Assiut University HospitalNo drug interventionsNot AvailableNot Availableunknown_status
NCT01373112
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee InfectionNo drug interventionstreatmentNot Availablecompleted