Endogenous Cushing's Syndrome (DBCOND0063178)

Identifiers

Synonyms

Endogenous Cushing Syndrome

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Lanosterol 14-alpha demethylasetarget Androgen receptortarget Steroid 17-alpha-hydroxylase/17,20 lyasetarget Steroid 21-hydroxylasetarget Voltage-gated inwardly rectifying potassium channel KCNH2target Nuclear receptor subfamily 1 group I member 2target Nuclear receptor subfamily 1 group I member 3target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 4F12enzyme Cytochrome P450 4F2enzyme Albumincarrier Sex hormone-binding globulincarrier Aromataseenzyme UDP-glucuronosyltransferase 1A7enzyme Lanosterol 14-alpha demethylasetarget
Levoketoconazole	One of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome.	Cytochrome P450 11B1, mitochondrialtarget Lanosterol 14-alpha demethylasetarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Steroid 21-hydroxylaseenzyme ATP-dependent translocase ABCB1transporter Steroid 17-alpha-hydroxylase/17,20 lyasetarget Cytochrome P450 11B2, mitochondrialtarget Cholesterol side-chain cleavage enzyme, mitochondrialtarget Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 7A1enzyme Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06430528	A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement	Osilodrostat	Not Available	Not Available	recruiting
NCT06131580	Canadian Continuation of Roll-over Study in Patients With Endogenous Cushing's Syndrome	No drug interventions	treatment	4	active_not_recruiting
NCT05382156	Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome	Osilodrostat	Not Available	Not Available	active_not_recruiting
NCT01838551	Treatment for Endogenous Cushing's Syndrome	Levoketoconazole	treatment	3	completed
NCT03880513	Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome)	No drug interventions	Not Available	Not Available	completed
NCT03277690	A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.	Levoketoconazole	treatment	3	completed