Immunocompromised

Also known as: Patient immunosuppressed / Immunocompromised Host / Immunodeficiency syndromes / Immunodeficiency, unspecified / Immunodeficiency NOS / Immunodeficiency / Unspecified immunity deficiency / Immunologic Deficiency Syndromes

DrugDrug NameDrug Description
DB00787AcyclovirA guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.
DB15718BamlanivimabA neutralizing human IgG1κ monoclonal antibody against the SARS-CoV-2 spike (S) protein for use in patients aged 12 and over at high risk of developing severe COVID-19.
DB15897EtesevimabEtesevimab in combination with bamlanivimab is used to treat mild to moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients, including neonates, with positive results of direct SARS-CoV-2 viral...
DB00529FoscarnetAn antiviral used to treat CMV, HIV, and HSV infections.
DB01004GanciclovirA DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
DB01263PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
DB01015SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
DB00864TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
DB00440TrimethoprimAn antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.
DB01157TrimetrexateA folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.
DrugDrug NameTargetType
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00787AcyclovirThymidine kinaseenzyme
DB00787AcyclovirGuanylate kinaseenzyme
DB00787AcyclovirNucleoside diphosphokinaseenzyme
DB00787AcyclovirPyruvate Kinasesenzyme
DB00787AcyclovirCreatine Kinasesenzyme
DB00787AcyclovirPhosphoglycerate Kinasesenzyme
DB00787AcyclovirSuccinyl-CoA Synthetasesenzyme
DB00787AcyclovirPhosphoenolpyruvate Carboxykinasesenzyme
DB00787AcyclovirAdenylosuccinate Synthetasesenzyme
DB00787AcyclovirSerum albumincarrier
DB15718BamlanivimabSpike glycoproteintarget
DB15897EtesevimabSpike glycoproteintarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB01004GanciclovirDNA polymerase catalytic subunittarget
DB01004GanciclovirThymidine kinasetarget
DB01004GanciclovirSolute carrier family 22 member 1transporter
DB01004GanciclovirSolute carrier family 22 member 6transporter
DB01004GanciclovirSolute carrier family 22 member 8transporter
DB01004GanciclovirSolute carrier family 22 member 7transporter
DB01004GanciclovirDNAtarget
DB01004GanciclovirMultidrug and toxin extrusion protein 1transporter
DB01004GanciclovirMultidrug and toxin extrusion protein 2transporter
DB01263PosaconazoleCytochrome P450 3A4enzyme
DB01263PosaconazoleP-glycoprotein 1transporter
DB01263PosaconazoleCytochrome P450 51target
DB01015SulfamethoxazoleCytochrome P450 2C9enzyme
DB01015SulfamethoxazoleSerum albumincarrier
DB01015SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
DB01015SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
DB01015SulfamethoxazoleDihydropteroate synthasetarget
DB01015SulfamethoxazoleCytochrome P450 3A4enzyme
DB01015SulfamethoxazoleBile salt export pumptransporter
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusP-glycoprotein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DB00864TacrolimusSolute carrier organic anion transporter family member 1B1transporter
DB00440TrimethoprimDihydrofolate reductasetarget
DB00440TrimethoprimCytochrome P450 2C8enzyme
DB00440TrimethoprimCytochrome P450 3A4enzyme
DB00440TrimethoprimP-glycoprotein 1transporter
DB00440TrimethoprimCytochrome P450 2C9enzyme
DB00440TrimethoprimCytochrome P450 1A2enzyme
DB00440TrimethoprimMultidrug and toxin extrusion protein 1transporter
DB00440TrimethoprimMultidrug and toxin extrusion protein 2transporter
DB01157TrimetrexateDihydrofolate reductasetarget
DB01157TrimetrexateFolate transporter 1transporter