Tonsillitis streptococcal (DBCOND0014527)

Identifiers

Synonyms

Streptococcal tonsillitis / Streptococcal tonsillitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Azithromycin	A macrolide antibiotic used to treat a variety of bacterial infections.	23S ribosomal RNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Protein-arginine deiminase type-4target ATP-binding cassette sub-family C member 2transporter
Cefaclor	A second generation cephalosporin used to treat a wide variety of infections in the body.	Penicillin-binding protein 1Atarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 3target Myeloperoxidaseenzyme Organic anion transporter 3transporter Bile salt export pumptransporter
Cefadroxil	A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Penicillin-binding protein 3target Penicillin-binding protein 1Atarget Penicillin-binding protein 1btarget Penicillin-binding protein 2Btarget
Cefdinir	A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.	Myeloperoxidasetarget Penicillin-binding protein 2target PBP3target Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Peptidoglycan transpeptidasetarget
Cefditoren	A broad-spectrum third-generation cephalosporin antibiotic typically used to treat bacterial infections of the skin and respiratory tract.	Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Cefixime	A third generation cephalosporin used to treat susceptible Gram-negative and Gram-positive bacterial infections.	Solute carrier family 15 member 1transporter Penicillin-binding proteintarget Penicillin-binding protein 2target Solute carrier family 22 member 7transporter Organic anion transporter 3transporter Solute carrier family 15 member 2transporter
Cefpodoxime	A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.	Peptidoglycan synthase FtsItarget
Cefprozil	A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 2xtarget Penicillin-binding protein 2Btarget
Ceftibuten	A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Clarithromycin	A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.	50S ribosomal protein L10target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 7transporter Voltage-gated inwardly rectifying potassium channel KCNH2target Solute carrier organic anion transporter family member 1B1target Solute carrier organic anion transporter family member 1B3target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Phenoxymethylpenicillin	A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.	Penicillin-binding protein 1Atarget MecA PBP2' (penicillin binding protein 2')target D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin acylasetarget Solute carrier family 15 member 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03137823	Diagnosis of GABHS Tonsillitis - Comparison Between Culture From Tonsills and Culture From the Bucal Surface	No drug interventions	diagnostic	Not Available	unknown_status
NCT04215770	Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin	Amoxicillin Benzylpenicillin Clavulanic acid	treatment	Not Available	completed