Idiopathic Hypogonadotropic Hypogonadism (DBCOND0037480)

Identifiers

Synonyms
Hypogonadism, Hypogonadotropic / Hypogonadotropic Hypogonadism / Central hypogonadism / Idiopathic hypogonadotropic hypogonadism / Hypopituitarism / Hypogonadotropic hypogonadism (disorder) / Secondary hypogonadism / Hypogonadotrophic hypogonadism / Idiopathic hypogonadotropic hypogonadism (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Chorionic Gonadotropin (Human)
A naturally-occurring hormone produced during human placenta used for the treatment of prepubertal cryptorchidism and hypogonadotropic hypogonadism in selected males, and induction of pregnancy in selected infertile women.
Fluoxymesterone
A synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.
Luteinizing hormone
Not Annotated
No drug targets
Methyltestosterone
A synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.
Testosterone
A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.
Testosterone enanthate
An androgen used to treat low or absent testosterone.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03245827
Hypogonadotropic Hypogonadism in Obese Young Malestreatment2terminated
NCT03490513
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadismtreatment4recruiting
NCT04733274
Patient and Healthcare Professional Views on Genetic/Genomic Information and TestingNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04927676
Hormones in Hypogonadotropic HypogonadismNo drug interventionsNot AvailableNot Availablerecruiting
NCT05569577
An Open Labeled RCT on the Effect of Additional hCG Injection for LPS on Pregnancy Outcomes in IHH PatientstreatmentNot Availablerecruiting
NCT01601327
Effects of Medications in Patients With Hypogonadismtreatment4completed
NCT06561594
To Evaluate Recombinant Human Follicle Stimulating Hormone-CTP Fusion Protein Injection or Placebo Combined With Chorionic Gonadotropin for Injectiontreatment3not_yet_recruiting
NCT02728440
Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With HypogonadismNot AvailableNot Availablecompleted
NCT01914172
Health Needs of Patients With Kallmann SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00493961
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadismother1completed
NCT01165619
Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency DisordersNo drug interventionsNot AvailableNot Availableterminated
NCT02310074
Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadismtreatment4unknown_status
NCT01758094
Plasma RBP Levels in Patients With Idiopathic Hypogonadotrophic HypogonadismNot AvailableNot Availablecompleted
NCT02042638
The Effects of Gonadotropin Replacement Therapy in Patients With HypogonadismNot AvailableNot Availablecompleted
NCT02154477
Effect of Intranasal Insulin on LH Concentrations in Mantreatment1 / 2completed
NCT05808647
Low Energy Availability and Pituitary Function (LEAP Study)No drug interventionsotherNot Availablerecruiting
NCT00383656
Pulsatile GnRH in Anovulatory Infertilitytreatment2unknown_status
NCT03019575
Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)treatment3completed
NCT06357442
Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05971836
The Molecular Basis of Inherited Reproductive DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT04975334
Opioid Antagonism in Hypogonadotropic Hypogonadismtreatment2enrolling_by_invitation
NCT02369796
A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadismtreatment2terminated
NCT00328926
LuverisĀ® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L])treatment4terminated
NCT05184374
Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HHdiagnosticNot Availableunknown_status
NCT01438073
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signalingother1completed
NCT05752591
Hypothalamic-pituitary Dysfunction in DiabetesNo drug interventionsNot AvailableNot Availablecompleted
NCT02880280
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadismtreatment4unknown_status
NCT02110368
Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditionstreatment3completed
NCT00494169
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT04648969
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadismtreatment2recruiting
NCT00914823
Kisspeptin Administration in the Adultother1completed
NCT03118479
Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)basic_science1terminated
NCT05896293
Kisspeptin Administration Subcutaneously to Patients With IHHother2recruiting
NCT01601171
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or PalateNo drug interventionsNot AvailableNot Availablerecruiting
NCT02062307
Bone Mineral Markers in HypogonadismNo drug interventionsNot AvailableNot Availablecompleted
NCT00392756
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)other1completed
NCT05205837
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trialtreatment4terminated
NCT01403532
Sequential Therapy for Hypogonadotropic Hypogonadismtreatment4completed
NCT01623570
Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HPtreatmentNot Availablecompleted
NCT01155518
Hypogonadism in Young Men With Type 2 Diabetestreatment2terminated
NCT01438034
Kisspeptin in the Evaluation of Delayed Pubertyother1completed
NCT04456296
A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadismtreatment4completed
NCT05633966
Kisspeptin Administration Subcutaneously to Patients With Reproductive Disordersother1recruiting
NCT02908074
A 6 Month Safety Extension Study of MBGS205treatment2completed
NCT00456274
Baselines in Reproductive DisordersNo drug interventionsdiagnosticNot Availableunknown_status
NCT01952782
Neuropeptides in Human Reproductionother1completed
NCT01709331
A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)treatment3completed
NCT04252001
Growing up With the Young Endocrine Support System (YESS!)No drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT02730169
Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic HypogonadismNo drug interventionstreatment2completed
NCT00697814
Clomiphene in Males With Prolactinomas and Persistent Hypogonadismtreatment2completed
NCT02705014
Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption SyndrometreatmentNot Availableunknown_status