Pancreatic Adenocarcinoma Locally Advanced (DBCOND0060223)

Identifiers

Synonyms

Locally Advanced Pancreatic Adenocarcinoma

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Gemcitabine	A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.	Ribonucleoside-diphosphate reductase large subunittarget UMP-CMP kinasetarget Thymidylate synthasetarget Cytidine deaminaseenzyme Deoxycytidine kinaseenzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 10transporter Equilibrative nucleoside transporter 1transporter DNAtarget Sodium/nucleoside cotransporter 1transporter Equilibrative nucleoside transporter 2transporter Solute carrier family 28 member 3transporter Thymidine kinase 2, mitochondrialenzyme UMP-CMP kinaseenzyme Nucleoside diphosphate kinase Aenzyme Ribonucleoside-diphosphate reductase subunit M2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01715142	Effect on Tumor Perfusion of a Chemotherapy Combining Gemcitabine and Nab-paclitaxel (Abraxane) in Pancreatic Cancer	Gemcitabine Paclitaxel	treatment	0	completed
NCT04570943	Sequential Treatment with GEMBRAX and Then FOLFIRINOX Followed by Stereotactic MRI-guided Radiotherapy in Patients with Locally Advanced Pancreatic Cancer	No drug interventions	treatment	2	recruiting
NCT04669197	Study of Paclitaxel Protein Bound + Gemcitabine + Cisplatin + Hydrochloroquine as Treatment in Untreated Pancreas Cancer	Cisplatin Gemcitabine Hydroxychloroquine Paclitaxel	treatment	2	active_not_recruiting
NCT06132087	PROACTIVE: Surgical Resection Outcomes in Locally Advanced and Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy	No drug interventions	treatment	Not Available	suspended
NCT04172532	Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer	Benzalkonium Nedisertib	treatment	1 / 2	recruiting
NCT06453486	A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment	Gemcitabine Paclitaxel	treatment	2	not_yet_recruiting
NCT05524090	PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer	No drug interventions	Not Available	Not Available	recruiting
NCT04617821	AG vs mFOLFIRINOX as Neoadjuvant Therapy for Borderline Reseactable and Locally Advanced Pancreatic Cancer	Albumin human Gemcitabine Paclitaxel	treatment	3	unknown_status
NCT03673137	Phase II/III of Randomized Controlled Clinical Research on IRE Synchronous Chemotherapy for LAPC	Gemcitabine	treatment	2 / 3	completed
NCT04652206	Clinical Trial to Investigate Safety, Tolerability and MTD for SCO-101 in Combination With Gemcitabine and Nab-paclitaxel in Inoperable Pancreatic Cancer Patients.	Gemcitabine Paclitaxel	treatment	1 / 2	unknown_status
NCT01342224	Immunochemoradiotherapy in Patients With Pancreatic Cancer	Gemcitabine Sargramostim Tadalafil Tertomotide	other	1	completed
NCT05825066	Neoadjuvant Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma	Gemcitabine Paclitaxel	treatment	2	recruiting
NCT05679674	Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer	No drug interventions	treatment	Not Available	recruiting
NCT03536182	Trial of Carbon Ion Versus Photon Radiotherapy for Locally Advanced, Unresectable Pancreatic Cancer	No drug interventions	treatment	3	withdrawn
NCT06272162	Locally Advanced Pancreatic Cancer After Systemic Therapy: Ablative MR-guided Radiotherapy	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT04718701	Anlotinib, Toripalimab and Nab-paclitaxel in Locally Advanced/Metastatic Pancreatic Cancer	Anlotinib Paclitaxel Toripalimab	treatment	2	unknown_status
NCT06399172	OncoSil Pancreatic Cancer Post-marketing Clinical Registry - Italy	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01278368	Effect Of Preoperative Chemotherapy On Short-Term Outcome After Pancreatic Resection	No drug interventions	treatment	Not Available	completed
NCT06381154	Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer	Fluorouracil Irinotecan Leucovorin Oxaliplatin Pembrolizumab Verteporfin	treatment	2	not_yet_recruiting
NCT05607953	Pressure Enabled Intrapancreatic Delivery of SD-101 With Checkpoint Blockade for Locally Advanced Pancreatic Adenocarcinoma	No drug interventions	treatment	1	recruiting
NCT04665947	First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer	Lutetium Lu-177	treatment	0	recruiting
NCT01585805	Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer	Chloride ion Cisplatin Gemcitabine Platinum Veliparib	treatment	2	active_not_recruiting
NCT03077685	Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma	Paclitaxel	treatment	2	completed
NCT00669734	Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery	Falimarev Inalimarev Sargramostim	treatment	1	active_not_recruiting
NCT03878524	Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial	Abemaciclib Abiraterone Afatinib Albumin human Avobenzone Bevacizumab Bicalutamide Bortezomib Bortezomib D-mannitol Cabazitaxel Cabozantinib Capecitabine Carboplatin Celecoxib Cobimetinib Copanlisib Dabrafenib Dacomitinib Darolutamide Dasatinib Daunorubicin Doxorubicin Durvalumab Enasidenib Entrectinib Enzalutamide Erlotinib Everolimus Fluorouracil Idelalisib Imatinib Ipilimumab Lenvatinib Leucovorin Lorlatinib Losartan Neratinib Nivolumab Octinoxate Olaparib Oxaliplatin Paclitaxel Palbociclib Panobinostat Pembrolizumab Pertuzumab Ponatinib Regorafenib Ruxolitinib Sirolimus Sorafenib Sunitinib Trametinib Trastuzumab emtansine Tretinoin Vemurafenib Venetoclax Vismodegib Vorinostat	treatment	1	terminated
NCT02394535	Nab-Paclitaxel, Capecitabine, and Radiation Therapy Following Induction Chemotherapy in Treating Patients With Locally Advanced Pancreatic Cancer	Albumin human Capecitabine Paclitaxel	treatment	1	completed
NCT05356039	Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer	No drug interventions	Not Available	Not Available	recruiting
NCT03269526	BATs Treatment for Pancreatic Cancer, Phase Ib/II	No drug interventions	treatment	1 / 2	active_not_recruiting
NCT04423731	Neoadjuvant Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer	Fluorouracil Gemcitabine Leucovorin Paclitaxel	Not Available	Not Available	active_not_recruiting
NCT05034627	Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer	Asparaginase Escherichia coli Benzalkonium Calaspargase pegol Carbonate ion Cobimetinib	treatment	1	recruiting
NCT04395469	FAZA PET/MRI Pancreas	Fluoroazomycin arabinoside F-18	diagnostic	Not Available	active_not_recruiting