Low-Grade Glioma (DBCOND0071589)

Identifiers

Synonyms
Low Grade Glioma (LGG) / Low Grade Glioma / Low-Grade Gliomas / Low Grade Gliomas / Low-grade glioma / Low grade glioma (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Dabrafenib
A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
Trametinib
A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02473380
Fluorescence Spectroscopy Guided SurgeryNo drug interventionsdiagnostic1completed
NCT03871257
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Gliomatreatment3recruiting
NCT03952598
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR SpectroscopyNo drug interventionsdiagnosticNot Availablerecruiting
NCT04166409
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Gliomatreatment3recruiting
NCT01089101
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Gliomatreatment1 / 2active_not_recruiting
NCT03718767
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotypetreatment2recruiting
NCT02023905
Everolimus With and Without Temozolomide in Adult Low Grade Gliomatreatment2terminated
NCT02840409
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)treatment2active_not_recruiting
NCT01288235
Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationNo drug interventionstreatment2active_not_recruiting
NCT04553757
Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade GliomaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03213665
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)treatment2active_not_recruiting
NCT01281982
(11C)dLop as a Marker of P-Glycoprotein Function in Patients With GliomasNo drug interventionsNot AvailableNot Availableterminated
NCT02286531
Evaluation de O-(2-[18F]-Fluoroethyl)-L-Tyrosine, a New Tracer PET, in the Diagnosis of Low Grade GliomadiagnosticNot Availablecompleted
NCT05964569
Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade GliomaNo drug interventionstreatment2recruiting
NCT03244995
Mind-Body Intervention in Glioma CouplesNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03749187
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomastreatment1recruiting
NCT02358187
A Vaccine Trial for Low Grade Gliomastreatment2recruiting
NCT01452854
Ovarian Aging in Low Grade Glioma (LGG) Treated With TemozolomideNo drug interventionsNot AvailableNot Availableterminated
NCT02455245
A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Gliomatreatment3unknown_status
NCT02607397
ROCOCO - Low Grade Glioma - Planning StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06132685
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trialtreatment2not_yet_recruiting
NCT04044937
Fluoroethyltyrosine for Evaluation of Intracranial Neoplasmsdiagnostic2completed
NCT01358058
Proton Radiation Therapy for GliomasNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02186262
Rotating Frame Relaxation and Diffusion Weighted Imaging of Human GliomasNo drug interventionsNot AvailableNot Availablecompleted
NCT03233204
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)treatment2completed
NCT01386450
AZD6244 in Children With Low-Grade Gliomastreatment1 / 2recruiting
NCT05566795
DAY101 Vs. Standard of Care Chemotherapy in Pediatric Patients with Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)treatment3recruiting
NCT04865315
A Living Tissue Bank of Patient-Derived Organoids From Glioma TumorsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06610851
Monitoring of Patients With Low-grade Gliomas Using Circulating miRNANo drug interventionsNot AvailableNot Availablerecruiting
NCT03948490
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade GliomasNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT06159478
Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)treatment2recruiting
NCT06104488
A Study of Avutometinib for People With Solid Tumor Cancerstreatment1recruiting
NCT04544007
A Phase II Trial of Poly-ICLC for Low-Grade Gliomastreatment2recruiting
NCT04775485
A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumorstreatment2recruiting
NCT05233215
GROW (Glioma Specialists Reaching Out With Support) SupportNo drug interventionssupportive_careNot Availablewithdrawn
NCT02197637
Phase II Trial of Oral Vinorelbine in Children With Recurrent or Progressive Unresectable Low-Grade Gliomatreatment2completed
NCT05406700
Niraparib In Recurrent IDH 1/2 Gliomastreatment0recruiting
NCT06381570
Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomastreatment0recruiting
NCT04316039
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgerytreatment2 / 3recruiting
NCT03763422
Trial in Low Grade Glioma Patients: Wait or Treattreatment3terminated
NCT04923126
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Gliomatreatment1 / 2recruiting
NCT00782626
Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomastreatment2completed
NCT04174820
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social CognitionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01497860
Vinorelbine for Children With Progressive or Recurrent Low-grade Gliomastreatment2completed
NCT01837862
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomastreatment1 / 2completed
NCT04734444
SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain TissueNo drug interventionsotherNot Availablerecruiting
NCT04346472
Longitudinal MRI Assessment in Patients With Diffuse Low-grade GliomasNo drug interventionsNot AvailableNot Availablecompleted
NCT05873946
Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT03429803
DAY101 In Gliomas and Other Tumorstreatment1active_not_recruiting
NCT04659421
Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade GliomasNo drug interventionstreatment2completed
NCT05996653
CEST in Low-grade Glioma StudyNo drug interventionsdiagnosticNot Availablerecruiting
NCT04485559
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)treatment1recruiting
NCT03363217
Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.treatment2active_not_recruiting
NCT05760586
Expanded Access Program (EAP) for Tovorafenib (DAY101) in RAF-Altered, Relapsed or Refractory Low-Grade GliomaNot AvailableNot Availableapproved_for_marketing
NCT05373394
Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor AreaNo drug interventionsNot AvailableNot Availablecompleted
NCT05555550
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGGdiagnostic0not_yet_recruiting
NCT00901849
Tarceva/Rapamycin for Children With Low-grade Gliomas With or Without Neurofibromatosis Type 1 (NF1)treatment1completed
NCT02285439
Study of MEK162 for Children With Low-Grade Gliomastreatment1 / 2active_not_recruiting
NCT00517959
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain TumorsNo drug interventionstreatment3unknown_status
NCT00681473
Late Effects of Proton Radiation Therapy in Patients With Low-Grade GliomaNo drug interventionstreatmentNot Availablecompleted