Central Retinal Vein Occlusion (CRVO) (DBCOND0079871)

Identifiers

Synonyms

Central Retinal Vein Occlusion / Central retinal vein occlusion (disorder) / Occlusion of retinal vein (disorder) / Retinal Vein Occlusion / Occlusion retinal vein

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Streptokinase	A purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism.	Plasminogentarget Proteinase-activated receptor 1target Cytosolic phospholipase A2enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02585401	Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada	Aflibercept	Not Available	Not Available	completed
NCT05476926	A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products	Faricimab Ranibizumab	Not Available	Not Available	recruiting
NCT01348633	Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye	No drug interventions	Not Available	Not Available	unknown_status
NCT01724554	Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion	Aflibercept	treatment	1 / 2	completed
NCT02390245	Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study	No drug interventions	other	Not Available	completed
NCT00500045	Retrospective Study of the Effectiveness and Safety of Niacin and Steroid Eye Drops for Retinal Vein Occlusions	Niacin	treatment	2 / 3	terminated
NCT00567697	A Randomized Study Comparing Ranibizumab to Sham in Patients With Macular Edema Secondary to CRVO	Ranibizumab	treatment	3	completed
NCT01396083	Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Central Retinal Vein Occlusion (CRVO)	Dexamethasone Ranibizumab	treatment	3	completed
NCT00969293	Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion	Ecallantide	treatment	1	terminated
NCT01360385	Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab	No drug interventions	Not Available	Not Available	completed
NCT00906685	Bevacizumab for Central Retinal Vein Occlusion Study	Bevacizumab	treatment	3	completed
NCT04793100	Spontaneous Retinal Artery Pulses (SPARs) as a Prognostic Determinant of Central Retinal Vein Occlusions (CRVO) in Patients With or Without Intravitreal Aflibercept Injections	Aflibercept	other	Not Available	active_not_recruiting
NCT02274259	Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen	Aflibercept Ranibizumab	treatment	4	completed
NCT02800642	Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO	Aflibercept	treatment	4	completed
NCT01531842	A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye	No drug interventions	supportive_care	Not Available	unknown_status
NCT00532142	The ROVO Study: Radial Optic Neurotomy for CVO	Triamcinolone	treatment	2 / 3	completed
NCT03981549	Treatment of Central Retinal Vein Occlusion Using Stem Cells Study	No drug interventions	treatment	1 / 2	completed
NCT03810313	Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion	Aflibercept Brolucizumab	treatment	3	terminated
NCT01448018	Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion	Ranibizumab	treatment	4	completed
NCT00406796	Lucentis for Central Retinal Vein Occlusion (CRVO)	Ranibizumab	treatment	1	completed
NCT01827722	Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion	Dexamethasone Ranibizumab	treatment	4	unknown_status
NCT02169648	Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion	Ranibizumab	treatment	Not Available	unknown_status
NCT01678248	The Effectiveness of Intravitreal Avastin Injection for CRVO	No drug interventions	Not Available	Not Available	unknown_status
NCT04740931	A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion	Aflibercept Faricimab	treatment	3	completed
NCT00383773	Retinal Endo Vascular Surgery for Central Retinal Vein Occlusion	No drug interventions	treatment	Not Available	unknown_status
NCT02173873	Ziv-aflibercept in Eyes With Retinal Diseases and Poor Vision-phase I	Aflibercept	treatment	1	unknown_status
NCT01303276	Retinal Blood Flow in Response to an Intravitreal Injection of Ranibizumab for Central Retinal Vein Occlusion (CRVO)	No drug interventions	Not Available	Not Available	unknown_status
NCT02503540	Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO	Aflibercept	treatment	4	completed
NCT03417401	Surgical Stabilizer Assisted RVC With rtPA for CRVO	Alteplase	treatment	1	withdrawn
NCT01976312	Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Central Retinal Vein Occlusion (CRVO)	Ranibizumab	treatment	3	completed
NCT04667910	601 Versus Ranibizumab in Patients With Central Retinal Vein Occlusion (CRVO)	Ranibizumab	treatment	2	unknown_status
NCT01793181	Vitamin D Levels in Patients With Central Retinal Vein Occlusion- a Prospective Controlled Study	No drug interventions	Not Available	Not Available	completed
NCT03223714	Conbercept Ophthalmic Injection for Patients of Central Retinal Vein Occlusion	Conbercept	treatment	3	completed
NCT00952614	A Study of a Sustained Release Fluocinolone Implant for Treatment of Central Retinal Vein Occlusion	No drug interventions	treatment	Not Available	completed
NCT00556114	A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging	No drug interventions	Not Available	Not Available	completed
NCT01231633	Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)	Bevacizumab Dexamethasone	treatment	Not Available	completed
NCT02091505	Predictive Factors of Ranibizumab Treatment in Macular Edema With CRVO	Ranibizumab	treatment	Not Available	unknown_status
NCT01178697	Intravitreal Bevasizumab Versus Intravitreal Triamcinolone in Central Retinal Vein Occlusion (CRVO)	Triamcinolone	treatment	2	unknown_status
NCT00566761	Treatment of Bevacizumab and Triamcinolone in Treatment or Macular Edema Secondary to CRVO	Bevacizumab Triamcinolone	treatment	4	terminated
NCT01535261	Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion	Ranibizumab	treatment	3	completed
NCT01581411	Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion	Alteplase	treatment	1	completed
NCT01640171	Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival	Aflibercept Bevacizumab Ketorolac Lidocaine Proparacaine Ranibizumab Tetracaine Water	treatment	Not Available	completed
NCT00211471	Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 mg.).	Anecortave acetate	treatment	2	terminated
NCT02405741	Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients	No drug interventions	treatment	2	unknown_status
NCT02747030	Phase I RVC With Ocriplasmin for CRVO	Ocriplasmin	treatment	1	completed
NCT01028248	Lucentis for Macular Edema Associated With Central Retinal Vein Occlusion	Ranibizumab	treatment	1	completed
NCT00517257	Atorvastatin for the Treatment of Retinal Vein Occlusion	Atorvastatin	treatment	3	unknown_status
NCT01011374	Impact of Lucentis on Psychological Morbidity in Patients With Retinal Vein Occlusion	Ranibizumab	treatment	1	unknown_status
NCT01471691	Intravitreal Ranibizumab 0.5MG, or 1.0mg for RVO With Macular Edema Previously Receiving Bevacizumab	Ranibizumab	treatment	1 / 2	completed
NCT04601701	Central Retinal Vein Occlusion (CRVO) Treatment With Bevacizumab and Dexamethasone or Bevacizumab Only.	Bevacizumab Dexamethasone	treatment	Not Available	unknown_status
NCT01969708	Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2)	Aflibercept Bevacizumab	treatment	3	completed