Treatment Resistant Schizophrenia (DBCOND0116884)

Identifiers

Synonyms

Schizophrenia, Treatment-Resistant / Treatment-resistant Schizophrenia / Schizophrenia, unspecified / Schizophrenia NOS / Dementia praecox / Schizophrenic disorders (disorder) / Unspecified schizophrenia / Unspecified schizophrenia, unspecified state / Schizophrenia / Schizophrenia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Clozapine	An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients.	D(4) dopamine receptortarget Histamine H1 receptortarget D(2) dopamine receptortarget Neuron-specific vesicular protein calcyontarget Histamine H4 receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Ctarget D(1A) dopamine receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme D(3) dopamine receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Flavin-containing monooxygenase 3enzyme UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme Glutathione S-transferase Ptarget Alpha-1-acid glycoprotein 1carrier Albumincarrier D(1B) dopamine receptortarget Gamma-aminobutyric acid type B receptor subunit 1target Gamma-aminobutyric acid type B receptor subunit 2target Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter Gamma-aminobutyric acid receptor subunit alpha-1target Gamma-aminobutyric acid receptor subunit beta-1target Gamma-aminobutyric acid receptor subunit gamma-1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05956600	An Open-Label, Single-Arm Clinical Trial Evaluating the Safety and Efficacy of Amisulpride in Treating Patients With Schizophrenia and Schizoaffective Disorder Who Have Treatment-Resistant Positive Symptoms	Amisulpride	treatment	Not Available	withdrawn
NCT06361160	Reduction of Auditory-Verbal Hallucinations in Schizophrenia Through Cortical Neuromodulation	No drug interventions	treatment	Not Available	recruiting
NCT06505668	Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.	No drug interventions	other	Not Available	recruiting
NCT05944510	Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia	No drug interventions	treatment	4	recruiting
NCT06456983	Maintenance ElectroConvulsive Therapy in Clozapine RESISTant Schizophrenia - the MECT-RESIST Trial	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03807882	Comparison of Maintenance ECT Versus Clozapine in Treatment-resistant Schizophrenia	No drug interventions	treatment	4	completed
NCT03230864	Efficacy of Lu AF35700 in Patients With Early-in-disease or Late-in-disease Treatment-resistant Schizophrenia	No drug interventions	treatment	3	terminated
NCT05074732	Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.	No drug interventions	Not Available	Not Available	recruiting
NCT05694000	Hippocampus DBS in Treatment-resistant Schizophrenia	No drug interventions	treatment	Not Available	recruiting
NCT03983018	Rituximab for Schizophrenia Spectrum Disorder (RITS-PS-2019)	Rituximab	treatment	1	completed
NCT06060886	Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis	Aripiprazole Paliperidone	treatment	4	not_yet_recruiting
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT05337904	Deep Brain Stimulation Recovery in Treatment-Resistant Schizophrenia	No drug interventions	treatment	Not Available	unknown_status
NCT01105481	Amisulpride Augmentation Therapy for Clozapine-resistant Schizophrenic Patients	No drug interventions	treatment	4	completed
NCT06270108	The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia	No drug interventions	basic_science	0	recruiting
NCT06128408	The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05741502	An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine	No drug interventions	diagnostic	4	recruiting
NCT02361554	Deep Brain Stimulation in Treatment Resistant Schizophrenia	No drug interventions	treatment	Not Available	recruiting
NCT04054778	Comparaison of Avatar Therapy to Cognitive Behavioral Therapy in Schizophrenia With Treatment Refractory Hallucinations	No drug interventions	treatment	Not Available	recruiting
NCT05259306	Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia	No drug interventions	treatment	Not Available	suspended
NCT05299749	Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations	No drug interventions	treatment	Not Available	recruiting
NCT03868839	Telmisartan Pilot Study on Treatment Resistant Schizophrenia	No drug interventions	other	2	terminated
NCT03148639	Virtual Reality Therapy for Treatment-resistant Auditory Hallucinations in Schizophrenia	No drug interventions	treatment	Not Available	completed
NCT03585127	Avatar Therapy in Comparison to Cognitive Behavioral Therapy for Treatment-resistant Schizophrenia	No drug interventions	treatment	Not Available	completed
NCT03076346	Neural Biomarkers of Clozapine Response	No drug interventions	Not Available	Not Available	completed
NCT04528095	SMART Design to Compare Antipsychotic Treatments in Treatment-Resistant Schizophrenia	No drug interventions	treatment	3	unknown_status