Pulmonary Arterial Hypertension (PAH) (DBCOND0039281)

Identifiers

Synonyms
Pulmonary Arterial Hypertension (CHD) / Arterial Hypertension, Pulmonary / Pulmonary Arterial Hypertention / Pulmonary Arterial Hypertension / Hypertension, Pulmonary Arterial / Hypertension, Pulmonary Artery / PAH / Pulmonary Arterial Hypertension PAH / WHO Group 1 Pulmonary Arterial Hypertension (PAH) / Pulmonary hypertensive arterial disease (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Adenosine
A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia.
Epoprostenol
A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
Macitentan
An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression.
Riociguat
A stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.
Sildenafil
A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
Tadalafil
A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
Treprostinil
A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05967299
Study of Intravenous ZMA001 in Healthy SubjectsNo drug interventionsbasic_science1recruiting
NCT06454422
Implementing the Wuqinxi on Patients With Pulmonary Arterial HypertensionNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT06477640
Home Rehabilitation Improves Cardiac Effort in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablerecruiting
NCT04084678
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PHtreatment3terminated
NCT04796337
A Long-term Follow-up Study of Sotatercept for PAH Treatment (MK-7962-004/A011-12)treatment3recruiting
NCT06553937
Bioequivalence Study of Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mgother1completed
NCT06553924
Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mgother1completed
NCT03449524
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)treatment2terminated
NCT03683186
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extensiontreatment3enrolling_by_invitation
NCT02276872
Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 YearsNo drug interventionstreatment2completed
NCT02149095
Dose Escalation, MTD, Safety and PK Study of a Single Dose SC Injection of TransCon PEG Treprostinil in Healthy Male VolunteersNo drug interventionstreatment1withdrawn
NCT04309838
Observation Study With Implantable Medication Pump for Intravenous Treprostinil Therapy in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT04053543
CXA-10 Study in Subjects With Pulmonary Arterial Hypertensiontreatment2terminated
NCT01092897
Pulmonary Hypertension and ImatinibNo drug interventionsNot AvailableNot Availablecompleted
NCT03626688
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH PatientsNo drug interventionstreatment3recruiting
NCT01320865
Biomarkers in Pulmonary Arterial Hypertension Treated With NilotinibNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03362047
(RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)treatment2recruiting
NCT01347216
COMPERA / COMPERA-KIDSNo drug interventionsNot AvailableNot Availablerecruiting
NCT00586794
Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger PatientsNo drug interventionstreatment3terminated
NCT05947240
Effects of UE Aerobic Exercise on Exercise Capacity and PA in Patients With Pulmonary Arterial Hypertension.No drug interventionstreatmentNot Availablecompleted
NCT03523910
Right Ventricular Pulmonary Vascular Interaction in Pulmonary HypertensionNo drug interventionsdiagnosticNot Availablecompleted
NCT03145298
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApyNo drug interventionstreatment1completed
NCT06493461
A Study of HS135 for the Treatment of Pulmonary Arterial Hypertension in AdultsNo drug interventionstreatment1not_yet_recruiting
NCT05546125
a Non-interventional Study of Sildenafil in the Treatment of Pulmonary Arterial Hypertension (PAH) in Adults From ChinaNo drug interventionsNot AvailableNot Availablecompleted
NCT03235401
The PAH Disability and Bothersomeness QuestionnaireNo drug interventionsNot AvailableNot Availableunknown_status
NCT01800292
Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.No drug interventionsdiagnostic4completed
NCT04663217
Exercise Hemodynamic, Right Ventricular Coupling and Echocardiography in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT05029167
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)No drug interventionstreatmentNot Availableunknown_status
NCT06172790
The Effects of the Otago Exercise ProgramNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03863990
Study Performed at Various Medical Centers to Learn More About Survival and Expected Course of Pulmonary Arterial Hypertension, a Type of High Blood Pressure in the Lungs Related to the Narrowing of the Small Blood Vessels in the LungsNo drug interventionsNot AvailableNot Availablecompleted
NCT04104490
Angiotensin Converting Enzyme (ACE2), Brain, Gut Dysbiosis in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT02631421
Dysregulation of Lipid Metabolism and Right Ventricular Function in PAHNo drug interventionsNot AvailableNot Availablecompleted
NCT05566002
Artificial Intelligence-assisted Evaluation of Pulmonary HYpertensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03928002
4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart DiseaseNo drug interventionsdiagnosticNot Availableunknown_status
NCT00423202
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.No drug interventionstreatment3completed
NCT04567602
A Study of Pulmonary Arterial Hypertension Participants Treated With Macitentan or SelexipagNo drug interventionsNot AvailableNot Availablecompleted
NCT03365479
Acute Response of Iloprost Inhalation Using the Breelib Nebulizer in Pulmonary Arterial HypertensionNo drug interventionsbasic_scienceNot Availablecompleted
NCT00878943
Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 StudyNo drug interventionsNot AvailableNot Availableno_longer_available
NCT04316143
Pharmacokinetics, Safety and Efficacy of BIA 5-1058 in PAHNo drug interventionstreatment2completed
NCT02112487
Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAHtreatment3completed
NCT01117987
Extension to QTI571A2301 to Evaluate the Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH)treatment3terminated
NCT00617487
Pulmonary Arterial Hypertension in Systemic SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT00705133
Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT05977933
Assessing the Utility of Submaximal CPET in Treatment Management of PAHNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00494533
Study of Intravenous Remodulin in Patients in India With Pulmonary Arterial HypertensionNo drug interventionstreatment4terminated
NCT02371733
Aerobic Exercise Training in Pulmonary Arterial HypertensionNo drug interventionssupportive_careNot Availablecompleted
NCT01477333
Addition of UT-15C SR to Pulmonary Arterial Hypertension Patients Currently Receiving Tyvaso®treatment2completed
NCT02579954
Cardiac Function and Exercise Capacity in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT00723554
Iloprost Power Disc-15 in Pulmonary Arterial HypertensionNo drug interventionstreatment3terminated
NCT04991454
Xenon MRI Pulm HypertensionNo drug interventionsdiagnostic2recruiting
NCT04489251
Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02734953
Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAHtreatment2completed
NCT01572077
Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial HypertensionNo drug interventionsbasic_scienceNot Availablecompleted
NCT03492177
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertensiontreatment2active_not_recruiting
NCT02676947
A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertensiontreatment2completed
NCT01165047
Nitric Oxide, GeNO Nitrosyl Delivery Systemtreatment2completed
NCT05828147
Anti-CD20 Antibodies for Treatment of SLE-PAHtreatment4recruiting
NCT01934647
Acute Dosing of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-003)No drug interventionstreatment1terminated
NCT00814645
Dose-Finding, Safety, Pharmacodynamic Effect Study of Sodium Nitrite Inhalation Solution in Normal, Healthy VolunteersNo drug interventionstreatment1completed
NCT01319045
Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart DiseasetreatmentNot Availableterminated
NCT04273945
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertensiontreatment3active_not_recruiting
NCT03838445
Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)No drug interventionstreatmentNot Availablerecruiting
NCT01647945
FK506 (Tacrolimus) in Pulmonary Arterial Hypertensiontreatment2completed
NCT02279745
Long-term Safety and Efficacy of Ralinepag in Pulmonary Arterial Hypertensiontreatment2completed
NCT02304198
Clinical Trial to Evaluate the Long-term Safety of Udenafil in Patient With PAHtreatment2 / 3completed
NCT01443598
Pulmonary Hypertension in Interstitial Lung DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03489005
Effect of BIA 5 1058 on Cardiac Repolarizationtreatment1completed
NCT00593905
Pharmacogenomics in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT06321705
Safety and Efficacy of Continued CS1 Treatment of Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableavailable
NCT00617305
Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)No drug interventionstreatment4completed
NCT05147805
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertensiontreatment2recruiting
NCT03954405
Multi-marker Approach for Risk Assessment in PAHNo drug interventionsNot AvailableNot Availablerecruiting
NCT06317805
Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patientstreatment4recruiting
NCT04266197
Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Studytreatment2recruiting
NCT01077297
Tezosentan in Pulmonary Arterial Hypertensiontreatment2terminated
NCT04908397
Carnitine Consumption and Augmentation in Pulmonary Arterial HypertensionNo drug interventionsother1completed
NCT06104228
129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)No drug interventionsdiagnostic2not_yet_recruiting
NCT03057028
Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertensiontreatment1completed
NCT03795428
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004treatment2terminated
NCT01447628
IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patientstreatment2completed
NCT01433328
Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Paintreatment4terminated
NCT01520493
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial HypertensionNo drug interventionsdiagnosticNot Availablecompleted
NCT04207593
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemiatreatment2completed
NCT01723371
Beta Blockers for Treatment of Pulmonary Arterial Hypertension in Childrentreatment1 / 2withdrawn
NCT00964678
Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertensiontreatment1 / 2completed
NCT03187678
Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertensiontreatment3completed
NCT00705588
Long Acting Phosphodiesterase 5 Inhibitors as Add-on Therapy for Patients With Pulmonary Hypertension Treated With Prostanoids.No drug interventionstreatment4unknown_status
NCT03197688
Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United StatesNo drug interventionsNot AvailableNot Availablecompleted
NCT00581607
Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary HypertensionNo drug interventionstreatment2 / 3completed
NCT01642407
Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertensiontreatment4completed
NCT02484807
Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAHNo drug interventionsNot AvailableNot Availablecompleted
NCT03496207
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)treatment2completed
NCT03078907
Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.other4completed
NCT05413109
COMPression of Left Main coRonary artEry in patientS With Pulmonary Arterial Hypertension aSymptomatIc fOr aNginaNo drug interventionsdiagnosticNot Availablerecruiting
NCT03889509
A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05179356
Dapagliflozin in Pulmonary Arterial Hypertensiontreatment2recruiting
NCT04972656
Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial HypertensiontreatmentNot Availablerecruiting
NCT01365585
Evaluate The Clinical Effectiveness, Safety And Tolerability Of Sildenafil Used In Doses ≥20mg TID For The Treatment Of Pulmonary Arterial HypertensionNot AvailableNot Availablecompleted
NCT03648385
Effects of DHEA in Pulmonary Hypertensiontreatment2active_not_recruiting
NCT01338415
FUTURE 3 Study Extensiontreatment3completed
NCT03612115
Neuromuscular Electrical Stimulation in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT02889315
LenusPro Pump in PAH Treated With TreprostinilNo drug interventionsNot AvailableNot Availableunknown_status
NCT03744637
A Study of Single Doses of MK -5475 on Pulmonary Vascular Resistance (MK-5475-002)No drug interventionstreatment1completed
NCT05818137
A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020)treatment3active_not_recruiting
NCT01560637
An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertensiontreatment3completed
NCT02284737
A Study to Investigate the Efficacy of PADN to Improved Functional Capacity and Hemodynamics in Patients With PAHtreatment4terminated
NCT04505137
A Study to Investigate Safe and Tolerable Dose of GMA301 Injection in Healthy VolunteersNo drug interventionstreatment1completed
NCT06350032
Investigational Trial to Evaluate Safety and Tolerability of Treprostinil in Children Diagnosed With PAHtreatment3recruiting
NCT05947032
Supervised Endurance Training Among Pulmonary Arterial Hypertension PatientsNo drug interventionstreatmentNot Availablecompleted
NCT06481852
A Placebo-controlled, Randomized Clinical Trial to Assess the Safety, Feasibility, and Pharmacokinetics of Microbiota Transplant Therapy With Antibiotic Preconditioning and Fiber Supplementation in Patients With Pulmonary Arterial HypertensionNo drug interventionssupportive_care1not_yet_recruiting
NCT01781052
Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension PatientsNot AvailableNot Availablecompleted
NCT01847352
Iron Status and Hypoxic Pulmonary Vascular Responsesbasic_scienceNot Availablecompleted
NCT02782052
Bronchodilator's Effects on Exertional Dyspnoea in Pulmonary Arterial Hypertensiontreatment3withdrawn
NCT01223352
Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertensiontreatment3completed
NCT03893500
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk TestNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT05587400
Consistency of Electrical Cardiometry and Pulmonary Artery CatheterdiagnosticNot Availablerecruiting
NCT04915300
Apabetalone for Pulmonary Arterial Hypertensiontreatment2not_yet_recruiting
NCT05135000
Study of Efficacy and Safety of LTP001 in Pulmonary Arterial HypertensionNo drug interventionstreatment2terminated
NCT06582459
Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associated Acute Respiratory FailureNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00303459
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)treatment4completed
NCT04650659
Functional Exercise Tests in Patients With Systemic SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05968859
A Study of Pulmonary Hypertension Peripheral LimitationsNo drug interventionstreatmentNot Availablerecruiting
NCT03344159
Spironolactone Therapy in Chronic Stable Right HF Trialtreatment4completed
NCT06476470
Taiwan Interstitial Lung Disease Multi-center Investigation and RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT05679570
Satralizumab in the Treatment of Pulmonary Arterial Hypertension (SATISFY-JP Trial)treatment2active_not_recruiting
NCT05624242
Assessment of Right Ventricular Function by Cardiac MRI in Patients With Pulmonary Arterial Hypertension (IRMA)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05557942
Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL)treatment3terminated
NCT03229499
Pulmonary Hypertension and Anastrozole Trialtreatment2completed
NCT01389206
Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension ProgramNot AvailableNot Availablecompleted
NCT03166306
Angiogenic Imaging in Pulmonary Arterial HypertensionNo drug interventionsdiagnostic1 / 2completed
NCT02999906
Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertensiontreatment3withdrawn
NCT02074449
Study Of Right Ventricular Performance In PAH Patients Treated With Rapid Dose Treprostinil (Remodulin)No drug interventionsNot AvailableNot Availablecompleted
NCT00377949
Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00609349
The Early Recognition of Pulmonary Arterial HypertensionNo drug interventionsscreeningNot Availablecompleted
NCT01798849
A Rising Single Dose Study of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics of MK-8892 (MK-8892-001)No drug interventionstreatment1completed
NCT01027949
An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertensiontreatment3completed
NCT01148836
Coenzyme Q-10 and Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT05521113
Home-based Pulmonary Rehabilitation With Remote Monitoring in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT05767918
StratosPHere (Non-interventional Study)No drug interventionsNot AvailableNot Availablecompleted
NCT05600218
RWD Patients With Pulmonary Arterial Hypertension Treated With IP Prostacyclin Receptor AgonistsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06528418
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled BreathNo drug interventionsNot AvailableNot Availablerecruiting
NCT02845518
Study of Cardiac MRI in the Follow up Assessment of Patients With PAH (EVITA)No drug interventionsdiagnosticNot Availablerecruiting
NCT03782818
Olaparib for PAH: a Multicenter Clinical Trialtreatment1 / 2recruiting
NCT00452218
Sorafenib Study: Dosing in Patients With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment1completed
NCT00554619
A Study to Evaluate GSK1325760A - a Long-Term Extension StudyNo drug interventionstreatment3completed
NCT04994119
Effect of BIA 5-1058 400 mg on Warfarin Pharmacokineticstreatment1completed
NCT00741819
Safety Evaluation of Inhaled Treprostinil Administration Following Transition From Inhaled Ventavis in Pulmonary Arterial Hypertension (PAH) SubjectsNo drug interventionstreatment4completed
NCT02800941
Bleeding Frequency Under Anticoagulant Treatment in Pulmonary HypertensionNot AvailableNot Availablecompleted
NCT02234141
Selonsertib in Adults With Pulmonary Arterial Hypertensiontreatment2completed
NCT05825417
Pulmonary Hypertension: Intensification and Personalisation of Combination Rxtreatment4recruiting
NCT03105934
Repeatability of OCT and IV-US in Pulmonary Arterial HypertensionNo drug interventionshealth_services_researchNot Availablecompleted
NCT01317134
Endothelial Function in Patients With Pulmonary Arterial HypertensionNo drug interventionsdiagnosticNot Availablecompleted
NCT06384534
Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy in Pulmonary Vascular Disease (PVD)No drug interventionsotherNot Availablenot_yet_recruiting
NCT04282434
DNA Methylation Dynamics Underlying Arterial Remodeling in PAH Patients: CLEOPAHTRA Clinical TrialNo drug interventionsNot AvailableNot Availablecompleted
NCT01560624
Phase III Clinical Worsening Study of UT-15C in Subjects With PAH Receiving Background Oral Monotherapytreatment3completed
NCT06092424
High Altitude (HA) Residents With Pulmonary Vascular Diseseases (PVD), Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) vs Sea Level (LA)No drug interventionssupportive_careNot Availableactive_not_recruiting
NCT00430716
To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.No drug interventionstreatment4terminated
NCT01494896
Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion MatchingNo drug interventionsNot AvailableNot Availableterminated
NCT04053296
Long-term Outcomes of Pregnant Women With PAHNo drug interventionsNot AvailableNot Availableunknown_status
NCT02958358
FDG Uptake and Lung Blood Flow in PAH Before and After Treatment With AmbrisentanNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01042158
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosistreatment4completed
NCT03522935
Subcutaneous Elafin in Healthy Subjectstreatment1completed
NCT00989963
Dose-response Study of the Safety and Efficacy of Beraprost Sodium Modified Release (BPS-MR) in Patients With Pulmonary Arterial Hypertension (PAH)treatment2completed
NCT02309463
Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01496963
Prevalence of Pulmonary Hypertension (PAH) in Patients With ThalassemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00086463
Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2completed
NCT05339386
Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial HypertensionNot AvailableNot Availablerecruiting
NCT00578786
A Long Term Study of Ambrisentan in Pulmonary Arterial Hypertension Subjects Having Completed AMB-320 (NCT00423748) or AMB-321 (NCT00423202)No drug interventionstreatment3completed
NCT05039086
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - PDE5 Inhibitors vs Endothelin Receptor AntagonistNo drug interventionsNot AvailableNot Availablecompleted
NCT01153386
Pharmacokinetic Linearity and Comparative Bioavailability of Treprostinil Diethanolaminetreatment1completed
NCT01649739
Vardenafil as add-on Therapy for Patients With Pulmonary Hypertension Treated With Inhaled Iloprosttreatment4unknown_status
NCT01409122
Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjectstreatment1completed
NCT05167825
A Study of Macitentan in Japanese Pediatric Participants With Pulmonary Arterial Hypertensiontreatment3active_not_recruiting
NCT03288025
Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)No drug interventionstreatmentNot Availableactive_not_recruiting
NCT04663230
Right Atrial Fibrosis in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT06429930
Safety, Tolerability and Pharmacokinetics Study of L608 in Healthy AdultsNo drug interventionstreatment1not_yet_recruiting
NCT04808830
Prevalence of Musculoskeletal Pain and Its Impact on Quality of Life and Functional Exercise Capacity in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT06550648
Evaluation of the Role of Epstein-Bar Virus in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT04813926
A Study to Learn About How Well Riociguat Works, How Safe it is and How it is Used Under Real World Conditions in Patients in the United States Who Are Receiving Riociguat for High Blood Pressure in the Arteries That Carry Blood From the Heart to the Lungs (Pulmonary Arterial Hypertension, PAH)Not AvailableNot Availableactive_not_recruiting
NCT05934526
Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)treatment3recruiting
NCT06405126
Validation of a Machine Learning Predictive Model to Distinguish Post-capillary Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01645826
Efficacy Study of Cardizem in Pulmonary Arterial HypertensiontreatmentNot Availablewithdrawn
NCT00483626
Hemodynamic Response After Six Months of SildenafilNo drug interventionstreatment4unknown_status
NCT01431326
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareNot AvailableNot Availablecompleted
NCT06409026
Sotatercept on Central Cardiopulmonary Performance and Peripheral Oxygen Transport During Exercise in Pulmonary Arterial Hypertensionother4recruiting
NCT00544726
Rehabilitation for Patients With Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availableunknown_status
NCT03282266
Safety and Efficacy of Pulmonary Artery Denervation in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT00995566
A Non-Interventional, Patient Registry For The Collection Of Pre-Defined Safety Data In Patients Prescribed ThelinNot AvailableNot Availableterminated
NCT05764265
Extension Study of Efficacy and Safety of LTP001 in Pulmonary Arterial Hypertension ParticipantsNo drug interventionstreatment2terminated
NCT03888365
Patient Global Impression Questions for Activity-Induced Symptoms in Participants With PAHNot AvailableNot Availablecompleted
NCT03556020
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAHtreatment2terminated
NCT01712620
Spironolactone for Pulmonary Arterial Hypertensiontreatment2recruiting
NCT01557582
Assessmet of Patients With PAH Right Ventricular VolumeNo drug interventionsNot AvailableNot Availablecompleted
NCT01934582
A Pharmacokinetic Substudy of the TDE-PH-304 Protocolother3completed
NCT04435782
A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magnetic Resonance Imagingtreatment4terminated
NCT02558231
The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertensiontreatment3completed
NCT01484431
A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertensiontreatment1 / 2completed
NCT01799473
Tyvaso Dosing and Titration Evaluation: TyTRATE RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT05417373
Algorithms to Diagnose Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01321073
DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support StudyNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT00963027
Effect of Esomeprazole on the Pharmacokinetics of Oral Treprostiniltreatment1completed
NCT01043627
Sildenafil to Tadalafil in Pulmonary Arterial Hypertension (SITAR)No drug interventionsNot AvailableNot Availablecompleted
NCT03401476
Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertensiontreatment2unknown_status
NCT05439460
Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertensiontreatment4completed
NCT02847260
Safety and Tolerability of Rapid Dose Titration of Subcutaneous Remodulin® Therapy in PAH Subjects (RAPID)treatment4completed
NCT04991194
Effect of Age-gender on the Pharmacokinetic and Pharmacodynamic Profiles of BIA 5 1058treatment1terminated
NCT02858791
MIF- Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01105091
Epoprostenol for Injection in Pulmonary Arterial Hypertensiontreatment4completed
NCT04450862
Anxiety Self-management Intervention for Pulmonary HypertensionNo drug interventionsotherNot Availableunknown_status
NCT01841762
Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrumenttreatment3completed
NCT01835080
Obstructive Sleep Apnea (OSA) in Pulmonary Arterial Hypertension (PAH)No drug interventionsNot AvailableNot Availableterminated
NCT01508780
Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral BosentanNo drug interventionsNot Available4withdrawn
NCT03718780
Assessment of Continuous Measurement of Transcutaneous CO2 for Evaluation of Alveolar Dead Space During ExerciseNo drug interventionsotherNot Availableunknown_status
NCT01355380
Efficacy of Ventavis Used in Real-life Setting.Not AvailableNot Availablecompleted
NCT05242380
Exercise Training in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT03476629
Effects of Different Types of Physical Training in Patients With Pulmonary Arterial Hypertension.No drug interventionstreatmentNot Availableunknown_status
NCT00433329
Combination Therapy in Pulmonary Arterial HypertensionNo drug interventionstreatment4completed
NCT03045029
ADAPT - A Patient Registry of the Real-world Use of Orenitram®Not AvailableNot Availableactive_not_recruiting
NCT03550729
Effects of Physical Training on Vascular Function as a Therapeutic Target in Pulmonary HypertensionNo drug interventionsbasic_scienceNot Availableactive_not_recruiting
NCT04930289
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05452889
PET Image in PAH PatientsNo drug interventionsdiagnostic0recruiting
NCT01623492
Eisenmenger Quality Enhancement Research InitiativeNo drug interventionsNot AvailableNot Availablecompleted
NCT04811092
Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13)No drug interventionstreatment3recruiting
NCT01470144
Epoprostenol for Injection in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT05948644
The Safety, Tolerability, and Pharmacokinetics of TPN171H Tablets in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment1completed
NCT03841344
Repeatability and Sensitivity to Change of Non-invasive Endpoints in PAHNo drug interventionsdiagnosticNot Availableunknown_status
NCT01302444
Treprostinil Combined With Tadalafil for Pulmonary HypertensionNo drug interventionstreatment4terminated
NCT01094067
Tezosentan in Patients With Pulmonary Arterial HypertensionNo drug interventionssupportive_care2terminated
NCT00319267
Bosentan in Children With Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT06196801
Efficacy of Triple-Combination Therapy in Severe PAH-CHDNo drug interventionsNot AvailableNot Availablerecruiting
NCT01743001
Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger SyndromeNo drug interventionstreatment3completed
NCT03251872
Olaparib for PAH: a Pilot StudyNo drug interventionstreatment0terminated
NCT02310672
REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtensionNo drug interventionstreatment4completed
NCT03567668
Surgical Valvuloplasty for Congenital Mitral InsufficiencyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02207868
3D Echo Evaluation of the Ventricles in Sclero Associated Severe PAHNo drug interventionsNot AvailableNot Availableunknown_status
NCT03016468
Safety of Transition From Selexipag to Remodulin® Then Oral Treprostinil in Symptomatic Adult PAHNo drug interventionstreatment2withdrawn
NCT00625469
Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With BosentanNo drug interventionstreatment4withdrawn
NCT01357746
Measuring Blood Pressure in the Lung Circulation With Sonar Technology (Echo-Doppler)No drug interventionsdiagnostic1terminated
NCT05938946
Safety, Tolerability and Pharmacokinetics of L608 in Healthy AdultsNo drug interventionstreatment1recruiting
NCT05587712
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)No drug interventionstreatment2recruiting
NCT02436512
Study to Assess Acute Vasodilation Response of Inhaled Nitric OxideNo drug interventionsdiagnostic3withdrawn
NCT00806312
The Expression and Significance of MiRNANo drug interventionsNot AvailableNot Availablecompleted
NCT02885012
Crossover Study From Macitentan or Bosentan Over to AmbrisentanNo drug interventionstreatment4terminated
NCT01397110
Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart DefectsNo drug interventionssupportive_careNot Availablerecruiting
NCT00796510
Study Providing Monotherapy (Sitaxsentan) And Combination Therapy (Sitaxsentan+Sildenafil) To Subjects With Pulmonary Arterial Hypertension (PAH) To Assess Long-Term SafetyNo drug interventionstreatment3terminated
NCT01457781
Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2completed
NCT05464095
The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) StudyNo drug interventionstreatmentNot Availablerecruiting
NCT03049995
Stress Echo 2020 - The International Stress Echo StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02893995
Safety, Tolerability, Pharmacokinetics and Efficacy of Two Different Rates of Subcutanous Remodulin® Dose Titration in Pulmonary Arterial HypertensionNo drug interventionstreatment4withdrawn
NCT03657095
A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial HypertensionNo drug interventionstreatment3terminated
NCT05622695
Non-invasive Pulmonary Artery PredictionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01907295
National Cohort Study of Idiopathic and Heritable Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01106014
Selexipag (ACT-293987) in Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT04791514
A Study of Treprostinil Palmitil Inhalation Powder (TPIP) In Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2terminated
NCT00453414
Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment2withdrawn
NCT01847014
Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT InstrumentNo drug interventionstreatment3terminated
NCT00990314
Extension of BPS-MR-PAH-203 in Pulmonary Arterial Hypertension (PAH) PatientsNo drug interventionstreatment2completed
NCT01451255
Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT04991155
Effect of Food on BIA 5-1058No drug interventionstreatment1completed
NCT04451850
HRV as a Marker of Treatment Response in PAH Arterial HypertensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT02835950
TReatment Of Pulmonary HYpertension 1-US StudyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00667823
Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT00926523
Biomarkers in the Evaluation of Chronic Lung DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02249923
Pediatric Pulmonary Hypertension Network (PPHNet) Informatics RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02961023
The Effect of Adding Exercise Training to Optimal Therapy in PAHNo drug interventionstreatmentNot Availablecompleted
NCT04280523
TranspulmonarY Estrogen Gradient and Estrogen Receptors (TYEGER) in PAHNo drug interventionsbasic_science2completed
NCT03638908
Fluoxetine in Pulmonary Arterial Hypertension (PAH) TrialNo drug interventionstreatment2completed
NCT04677608
Pulmonary Hypertension Modality of Death and Validation of REVEAL Risk ScoreNo drug interventionsNot AvailableNot Availableunknown_status
NCT00942708
Safety and Efficacy of Fluoxetine in Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT01330108
Safely Change From Bosentan to Ambrisentan in Pulmonary HypertensionNo drug interventionstreatment4completed
NCT00993408
Study of ACT-293987 (NS-304) in Pulmonary Arterial Hypertension (PAH)No drug interventionsother2completed
NCT01582438
An Open Label Access Study For Subjects Who Completed A1481156No drug interventionsNot AvailableNot Availableno_longer_available
NCT03810443
Prevalence of the Hyperventilation Syndrome in Pulmonary Arterial HypertensionNo drug interventionsdiagnosticNot Availableunknown_status
NCT01461343
Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography ImagingNo drug interventionsotherNot Availablecompleted
NCT02126943
OPsumit USers RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT03789643
Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial HypertensionNo drug interventionstreatment2withdrawn
NCT00902603
Ventavis® Registry ProtocolNo drug interventionsNot AvailableNot Availableterminated
NCT02081690
A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and SpainNo drug interventionstreatment3terminated
NCT04955990
A Study of Real-world Cohort of Pulmonary Arterial Hypertension (PAH) ParticipantsNo drug interventionsother4terminated
NCT01721564
Bosentan and Pulmonary Endothelial FunctionNo drug interventionstreatmentNot Availablecompleted
NCT03464864
Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal VolunteersNo drug interventionsother1completed
NCT04732221
A Study of the Efficacy and Safety of MK-5475 in Participants With Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007)No drug interventionstreatment2 / 3completed
NCT01553721
Efficacy and Safety Study of Udenafil in Patient With Pulmonary Arterial Hypertension(PAH)No drug interventionstreatment2completed
NCT03055221
TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment4completed
NCT03528902
Tamoxifen Therapy to Treat Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT01966302
Compassionate Use of Beraprost Sodium 314d Modified Release for Patients With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2completed
NCT03278002
A Registry for Patients Taking UptraviNo drug interventionsNot AvailableNot Availablecompleted
NCT04744584
Medication Reconciliation in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01181284
Modulating Effects of Lisinopril on Sildenafil Activity in Pulmonary Arterial Hypertension(PAH)( MELISSA)No drug interventionsNot AvailableNot Availablecompleted
NCT02799979
3D Imaging: Prognostic Role in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT00660179
Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT03933579
The PAH Platform for Deep Phenotyping in Korean SubjectsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05861479
Prognostic Value of Estimated Plasma Volume in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT00625079
Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With SildenafilNo drug interventionstreatment4withdrawn
NCT06567379
Myocardial Work Evaluation in Patients With PAHNo drug interventionsNot AvailableNot Availablerecruiting
NCT02980887
Pulmonary Vascular Disease Phenomics Program PVDOMICSNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02060487
Effects of Oral Sildenafil on Mortality in Adults With PAHNo drug interventionstreatment4terminated
NCT02080533
Feasibility of Slow-paced Respiration Therapy for Treatment of a Symptom Cluster in Pulmonary Arterial HypertensionNo drug interventionstreatment1 / 2completed
NCT02899533
[18F]FES PET/CT in PAHNo drug interventionsNot AvailableNot Availableterminated
NCT04503733
A Study of GMA301 in Subjects With Pulmonary Arterial HypertensionNo drug interventionstreatment1unknown_status
NCT03924154
A Study of RVT-1201 in Patients With Pulmonary Arterial Hypertension (ELEVATE 1)No drug interventionstreatment2terminated
NCT01260454
The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site PainNo drug interventionstreatment2completed
NCT04691154
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILDNo drug interventionstreatment3recruiting
NCT00722254
Reversible Secondary Myelofibrosis or Clonal Myeloproliferative DisorderNo drug interventionsNot AvailableNot Availableterminated
NCT01028651
A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01268553
Transition From Injectable Prostacyclin Medication to Inhaled Prostacyclin MedicationNo drug interventionstreatment4completed
NCT03819777
Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH)No drug interventionsNot AvailableNot Availableunknown_status
NCT01557647
Safety and Efficacy of Inhaled Treprostinil in Patients With PAHNo drug interventionstreatment3withdrawn
NCT06543745
Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial HypertensionNo drug interventionsotherNot Availablenot_yet_recruiting
NCT06351345
129 Xenon Imaging in Patients Treated With SotaterceptNo drug interventionsdiagnostic2not_yet_recruiting
NCT04125745
Oral CXA-10 in Pulmonary Arterial HypertensionNo drug interventionstreatment2terminated
NCT01066845
Post Marketing Observational Study in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01468545
Educational Training Influence in Patients With PAH(Pulmonary Artery Hypertension) on Inhaled Ventavis Treatment Adherence Evaluated Trough INSIGHT SystemNo drug interventionsNot AvailableNot Availablecompleted
NCT01131845
The Effect of Renal Impairment on the Pharmacokinetics of Oral TreprostinilNo drug interventionstreatment1completed
NCT04787445
Effects of Pulmonary Hypertension Therapy in Atypical Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT03688698
PET/MRI in PAH PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00709098
Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT01600898
Screening of Pulmonary Arterial Hypertension in BMPR2 Mutation CarriersNo drug interventionsNot AvailableNot Availablecompleted
NCT05975905
A Study to Investigate the Safety and Efficacy of KER-012 in Combination With Background Therapy in Adult Participants With Pulmonary Arterial Hypertension (PAH) (TROPOS Study).No drug interventionstreatment2recruiting
NCT01054105
Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01588405
Remodulin® to Oral Treprostinil TransitionNo drug interventionstreatment2completed
NCT00323297
Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial HypertensionNo drug interventionstreatment4completed
NCT04241497
Home-based Exercise Training in Patients With Pulmonary Arterial Hypertension: Effect on Skeletal Muscular Function and MetabolismNo drug interventionstreatmentNot Availableunknown_status
NCT01712997
Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension PatientsNo drug interventionstreatment3unknown_status
NCT01383083
Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT02471183
Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT03905083
miRNA and Myokines in Patients With PAHNo drug interventionsbasic_scienceNot Availablewithdrawn
NCT00866983
Local Open-Label Access Study For Patients Who Completed A1481244 Study In BrazilNo drug interventionsNot AvailableNot Availableno_longer_available
NCT04555161
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension SystemNo drug interventionstreatmentNot Availablerecruiting
NCT05745961
Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)No drug interventionsNot AvailableNot Availablerecruiting
NCT03422328
A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.No drug interventionstreatment3completed
NCT03977428
Central China Congenital Heart Disease Associated Pulmonary Arterial Hypertension Cohort StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT04570228
TROPHY PAH Pivotal Study - TReatment of Pulmonary HYpertension for PAH Pivotal StudyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06312111
Physical Activity and Various Aspects of Quality of Life in Patients With Pulmonary Arterial Hypertension (Ph-PAH)No drug interventionstreatmentNot Availablecompleted
NCT01659411
Adult Congenital Heart Disease Registry (QuERI)No drug interventionsNot AvailableNot Availablecompleted
NCT05185011
Study of the Pharmacokinetics and Safety of TPN171H Tablets in Subjects With Mild ,Moderate Hepatic Insufficiency and Normal Liver FunctionNo drug interventionstreatment1completed
NCT02507011
Beta-blockers in Pulmonary Arterial HypertensionNo drug interventionstreatment2terminated
NCT05618093
Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPHNo drug interventionsdiagnosticNot Availableenrolling_by_invitation
NCT03926793
Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial HypertensionNo drug interventionstreatment1completed
NCT02799771
HYPID (Pulmonary Hypertension in Interstitial Lung Disease) EXTENSIONNo drug interventionsNot AvailableNot Availablecompleted
NCT04884971
Microbiota Transplant Therapy for Pulmonary Arterial Hypertension: Early Safety and Feasibility StudyNo drug interventionstreatment1completed
NCT00792571
An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) PatientsNo drug interventionstreatment2completed
NCT01265888
Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl.No drug interventionstreatment2completed
NCT04576988
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)No drug interventionstreatment3completed
NCT04991207
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of BosentanNo drug interventionstreatment1completed
NCT03315507
A Study to Assess the Safety, Tolerability, and Hemodynamic Response of PB1046 in Subjects With PAHNo drug interventionstreatment1completed
NCT00832507
Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2terminated
NCT01926509
Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-005)No drug interventionstreatment1completed
NCT04528056
Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial HypertensionNo drug interventionstreatment1 / 2unknown_status
NCT00709956
Iloprost Power 15 in Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT02000856
BEET PAH: a Study to Assess the Effects of Beetroot Juice in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT01725256
A Phase 2 Study to Determine the Safety and Efficacy of AIR001 in Subjects With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2terminated
NCT05665556
REgistry of Pulmonary Arterial Hypertension Associated With CONNECTIVE Tissue Diseases (RECONNECTIVE)No drug interventionsNot AvailableNot Availablerecruiting
NCT06009185
Safety and Efficacy of BIA 5-1058 in PAHNo drug interventionstreatment2completed
NCT00781885
A Multi-Center, Open-Label, Multiple Dose, Dose Finding Study Exploring the Safety and Tolerability of Beraprost Sodium Modified Release in PAH PatientsNo drug interventionstreatment2completed
NCT01959815
Novel Screening Strategies for Scleroderma PAHNo drug interventionsNot AvailableNot Availablecompleted
NCT05060315
Evaluate Real-World Use of Next Generation Infusion Pumps to Administer RemodulinNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05124015
Exercise Capacity Respiratory Muscle Strength Dyspnea and Physical Activity in Pediatric Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT04483115
Acute Haemodynamic Study of TPN171H in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT04086537
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01179737
Efficacy, Safety, Tolerability and Pharmacokinetics (PK) of Nilotinib (AMN107) in Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2terminated
NCT05343637
A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT05564637
A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary HypertensionNo drug interventionstreatment2enrolling_by_invitation
NCT06072937
IntelliStent for Pulmonary Flow Adjustment in Congenital Heart Disease and Dilated CardiomyopathyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02746237
Single and Multiple Ascending Doses Clinical Pharmacology Study With KAR5585No drug interventionstreatment1completed
NCT06549452
Mobile Health Intervention to Improve Exercise in Pediatric PHNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01739400
Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger SyndromeNo drug interventionstreatment3terminated
NCT01092559
Pilot Study Evaluating the Safety and Performance of the GeNO NITROsyl Delivery System for Inhaled Nitric OxideNo drug interventionsdiagnostic2completed
NCT01827059
Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasENo drug interventionstreatment2unknown_status
NCT05641675
Non-invasive Pulmonary Artery Prediction (ADOPTS)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01637675
Efficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary HypertensionNo drug interventionstreatment2 / 3unknown_status
NCT00621075
Correlation OF Hemodynamics in Pulmonary Hypertension With Perfusion Lung ScansNo drug interventionsNot AvailableNot Availablecompleted
NCT00367770
BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger PhysiologyNo drug interventionstreatment4completed
NCT02036970
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIATNo drug interventionstreatment2completed
NCT01457170
Effects of Apelin on the Lung Circulation in Pulmonary HypertensionNo drug interventionsbasic_scienceNot Availableunknown_status
NCT06137742
A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial HypertensionNo drug interventionsbasic_science1recruiting
NCT02939599
Long-term Extension Study of the Safety and Pharmacokinetics of QCC374 in PAH PatientsNo drug interventionstreatment2terminated
NCT01908699
Beraprost-314d Added-on to Tyvaso® (BEAT)No drug interventionstreatment3completed
NCT02028299
Estimation of Pulmonary Vascular Resistance by Contrast EchocardiographyNo drug interventionsdiagnosticNot Availablecompleted
NCT02583906
Sleep Disordered Breathing in Precapillary Pulmonary Hypertension: Effect of CPAP TreatmentNo drug interventionstreatmentNot Availableterminated
NCT01112306
ACT-293987 in Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT02736149
Open-Label Extension Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1)No drug interventionstreatment2terminated
NCT01458236
A Multinational, Multicenter, Study to Assess the Efficacy and Safety of BPS-314d-MR in Subjects With Pulmonary Arterial Hypertension Currently Receiving Treatment With an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 InhibitorNo drug interventionstreatment3withdrawn
NCT02032836
Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)No drug interventionstreatment1 / 2completed
NCT01545336
Anastrozole in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT01100736
Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)No drug interventionsbasic_science0completed
NCT00811018
A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients With Pulmonary Arterial HypertensionNo drug interventionsNot Available3terminated
NCT03236818
Goal Oriented Strategy to Preserve Ejection Fraction TrialNo drug interventionstreatment4unknown_status
NCT06176118
Clinical Trial of 2-HOBA in Pulmonary Arterial HypertensionNo drug interventionstreatment2not_yet_recruiting
NCT02391441
Ventricular Reversed Remodeling After LTX in PAH PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04076241
Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT01105117
Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401No drug interventionstreatment4completed
NCT05437224
Efficacy and Safety Study of Ambrisentan in Chinese Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT01847716
Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availableterminated
NCT01431716
Epoprostenol for Injection (EFI/ACT-385781A) - Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT03069716
A Mobile Health Intervention in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT06180096
Bioequivalence Study of Riociguat 2.5 mg Film Coated Tablets and Adempas (Riociguat) 2.5 mg Film Coated TabletsNo drug interventionsother1completed
NCT01172496
A Bioavailability Study Comparing Treprostinil Diethanolamine Oral Tablets and Oral Solution in Healthy VolunteersNo drug interventionstreatment1completed
NCT04808596
Pulmonary Hypertension Biorepository and RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02664558
A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1)No drug interventionstreatment2completed
NCT05036135
A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2 / 3terminated
NCT02763735
Right Ventricular Metabolism in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT01251835
Effect Of Rifampin On Pharmacokinetics Of SitaxsentanNo drug interventionsbasic_science1withdrawn
NCT01864863
To Compare the Pharmacokinetics of Traclear 62.5 mg Tablets and HGP1206 125mg 1 Tablet in Healthy Male VolunteersNo drug interventionstreatment1completed
NCT05660863
A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of MN-08 TabletsNo drug interventionstreatment1not_yet_recruiting
NCT03051763
The Effects of Commercial Air Travel on Patients Suffering From Pulmonary HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02318186
Pharmacokinetic Study of Sub-q and IV Treprostinil in Kids With Pulmonary Arterial Hypertension (PAH)No drug interventionsNot AvailableNot Availablecompleted
NCT03950739
Open-label, Clinical Study to Evaluate the Safety and Tolerability of TreT in Subjects With PAH Currently Using TyvasoNo drug interventionstreatment1completed
NCT00795639
Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS)No drug interventionstreatment3terminated
NCT02516722
TReatment Of Pulmonary HYpertension 1 StudyNo drug interventionstreatmentNot Availableunknown_status
NCT01792622
Patient Reported Outcomes in Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03554330
Combined Use of Radiofrequency-ablation and Balloon-septostomy in the Creation of a Stable Inter-atrial CommunicationNo drug interventionstreatmentNot Availablerecruiting
NCT04903730
Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation SolutionNo drug interventionsbasic_science1completed
NCT00423748
Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.No drug interventionstreatment3completed
NCT01446848
Oral Iron Supplementation in Pulmonary HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT05649748
An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2 / 3recruiting
NCT03959748
DataBase of pulmoNary hyPertesion in PoLish Population - BNP-PLNo drug interventionsNot AvailableNot Availablerecruiting
NCT01251848
Drug Interaction Between Ritonavir And SitaxsentanNo drug interventionsbasic_science1withdrawn
NCT04041648
Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606other1completed
NCT01352026
Evaluation of Metformin Activity in Addition to Conventional Treatment of Grade II or III Pulmonary Arterial Hypertension (PAH)No drug interventionsNot Available2withdrawn
NCT02525926
Pulmonary Artery Denervation for Treatment of Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availableterminated
NCT02882126
An Open Label Extension Study to Evaluate the Safety of Continued Therapy of Subcutanous Remodulin® in Pulmonary Arterial HypertensionNo drug interventionstreatment4withdrawn
NCT02927366
Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH PatientsNo drug interventionstreatment2terminated
NCT01880866
(-)-Epicatechin and Pulmonary Arterial HypertensionNo drug interventionstreatment1withdrawn
NCT00796666
Study Looking at Combination Therapy (Sitaxsentan+Sildenafil) Vs. Monotherapy (Sitaxsentan Alone) SR-PAAS -Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding SildenafilNo drug interventionstreatment3terminated
NCT03045666
Impact of Rehabilitation Program on PAH Patients Treated With Macitentan.No drug interventionssupportive_careNot Availableunknown_status
NCT04090866
Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot StudyNo drug interventionsNot AvailableNot Availableterminated
NCT04062565
Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAHtreatment3unknown_status
NCT03884465
Hemodynamic Evaluation of Dose-response and Safety of Dry Powder Inhalation of TreprostinilNo drug interventionstreatment2terminated
NCT01266265
Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH TherapiesNo drug interventionsNot AvailableNot Availablecompleted
NCT00159874
A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Childrentreatment3completed
NCT00902174
Imatinib (QTI571) in Pulmonary Arterial HypertensionNo drug interventionstreatment3completed
NCT00319020
Bosentan in Children With Pulmonary Arterial Hypertension Extension StudyNo drug interventionstreatment3completed
NCT01244620
A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple DosesNo drug interventionstreatment1terminated
NCT03683082
Oxygen Treatment and Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availableunknown_status
NCT00706082
Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc)No drug interventionsNot AvailableNot Availableterminated
NCT05224531
Effect of CS1 in Subjects With Pulmonary Arterial HypertensionNo drug interventionstreatment2recruiting
NCT00435331
6R-BH4 Pulmonary Arterial Hypertension StudyNo drug interventionstreatment1completed
NCT06445673
A Prospective Non-interventional Observational Study to Observe Long-term Treatment and Outcomes in Pulmonary Arterial Hypertension (PAH) PatientsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01445873
Pilot Chart Review Study Of Sitaxentan Sodium (Thelin) In Patients With Pulmonary Arterial Hypertension (PAH)No drug interventionsNot AvailableNot Availablecompleted
NCT06484673
Bioequivalence Study to Compare Bosentan 32 mg Dispersible Tablets Versus Tracleer® 32 mg TabletsNo drug interventionsother1completed
NCT01174173
Ranolazine and Pulmonary HypertensionNo drug interventionstreatment3completed
NCT04071327
Pulmonary Hypertension Association RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT01615627
Hypotonic Treprostinil Subcutaneous Infusion for Control of Treprostinil Related Site PainNo drug interventionstreatment4withdrawn
NCT01165476
Comparative Bioavailability of Treprostinil Diethanolamine Manufactured by Two Independent FacilitiesNo drug interventionstreatment1completed
NCT04994860
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of SildenafilNo drug interventionstreatment1completed
NCT01557660
Inhaled Treprostinil for PAH: Open-label ExtensionNo drug interventionstreatment3withdrawn
NCT02279160
Safety and Efficacy of APD811 in Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT02253394
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension StudyNo drug interventionstreatment4terminated
NCT05343091
Prognostic Value of the Right Ventricular Function by Portable Ultrasound in Patients With Pulmonary Hypertension.No drug interventionsNot AvailableNot Availableunknown_status
NCT03554291
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary HypertensionNo drug interventionstreatment2completed
NCT05427162
A Study of Single and Multiple Doses of Different Formulations of a Prostacyclin Receptor AgonistNo drug interventionstreatment1completed
NCT06053580
Repurposing Valsartan May Protect Against Pulmonary HypertensionNo drug interventionstreatment2recruiting
NCT00058929
A Transition Study From Flolan® to Remodulin® in Patients With Pulmonary Arterial Hypertensiontreatment4completed
NCT02652429
Long-Term Extension Study of Inhaled Nitric Oxide (iNO) for PAHNo drug interventionstreatment3unknown_status
NCT01905189
Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availableunknown_status
NCT04254289
Pilot Randomized Trial of Ambulatory Exercise in Pulmonary HypertensionNo drug interventionssupportive_careNot Availablewithdrawn
NCT01607489
Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed TomographyNo drug interventionsdiagnosticNot Availablecompleted
NCT03497689
EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial HypertensionNo drug interventionstreatment4completed
NCT02691689
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt LesionsNo drug interventionsdiagnosticNot Availablerecruiting
NCT01208792
Auto-immunity and Pulmonary Arterial HypertensionNo drug interventionsdiagnosticNot Availablecompleted
NCT04675944
Effect of BIA 5-1058 on the Steady State Pharmacokinetics of TreprostinilNo drug interventionstreatment1completed
NCT02911844
Estrogen Receptor Antagonist in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT03364244
Revatio Special Investigation for Long-term Use in Pediatric PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01897740
Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With SildenafilNo drug interventionsNot AvailableNot Availableno_longer_available
NCT05368467
National Registry and Cohort Study of Pulmonary Vascular DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06274801
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)No drug interventionstreatment3not_yet_recruiting
NCT00963001
Effect of Food on the Pharmacokinetics of Oral TreprostinilNo drug interventionstreatment1completed
NCT06554301
A Study on the Efficacy and Safety of Empagliflozin in the Treatment of Pulmonary Arterial HypertensionNo drug interventionstreatment1not_yet_recruiting
NCT02968901
Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA)No drug interventionstreatment4terminated
NCT04278404
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)Not AvailableNot Availablerecruiting
NCT03655704
Apabetalone for Pulmonary Arterial Hypertension: a Pilot StudyNo drug interventionsscreening0completed
NCT04816604
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment2recruiting
NCT01391104
Responsiveness of Exercise Tests in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT01829672
Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed TomographyNo drug interventionsdiagnosticNot Availablecompleted
NCT02725372
Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAHNo drug interventionstreatment3terminated
NCT01392469
Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension ParticipantsNo drug interventionstreatment3completed
NCT04712669
A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (ELEVATE 2)No drug interventionstreatment2completed
NCT01725269
Long-term Study of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension Who Completed AIR001-CS05No drug interventionstreatment2terminated
NCT00477269
Safety and Efficacy of Imatinib Mesylate in Patients With Pulmonary Arterial HypertensionNo drug interventionstreatment2 / 3completed
NCT00439946
Safety, Efficacy, and Treatment Satisfaction Switching From Flolan to Remodulin Using the Crono Five Ambulatory Pump in Patients With PAHNo drug interventionstreatment4terminated
NCT03708146
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 5-1058No drug interventionstreatment1completed
NCT04778046
Pulmonary Hypertension SOLARNo drug interventionsdiagnostic2recruiting
NCT02932410
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment3active_not_recruiting
NCT04968210
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)No drug interventionsNot AvailableNot Availablerecruiting
NCT05203510
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial HypertensionNo drug interventionstreatment4recruiting
NCT05655481
Telerehabilitation Program Via Videoconference PAH - Randomized Clinical TrialNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03602781
Study of PAH Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled NitricNo drug interventionstreatment3withdrawn
NCT04991181
Absorption, Distribution, Metabolism and Excretion of BIA 5-1058No drug interventionstreatment1completed
NCT01392495
Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment3terminated
NCT05208814
a Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insufficiency and Healthy SubjectsNo drug interventionstreatment1completed
NCT02885155
Contribution of Echocardiography to Prognostic Evaluation of Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT05569655
Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAHNo drug interventionstreatmentNot Availableunknown_status
NCT01548950
Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary HypertensionNo drug interventionstreatmentNot Availablecompleted
NCT05318950
A nUtrition and Lifestyle Intervention in Patients With Pulmonary Arterial HypertensIonNo drug interventionstreatmentNot Availablecompleted
NCT02023450
Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial HypertensionNo drug interventionstreatment0unknown_status
NCT03738150
A Study of Sotatercept for the Treatment of Pulmonary Arterial HypertensionNo drug interventionstreatment2completed
NCT04416750
Positioning Imatinib for Pulmonary Arterial HypertensionNo drug interventionstreatment2active_not_recruiting
NCT00403650
Inhaled Iloprost for Sarcoidosis-associated Pulmonary HypertensionNo drug interventionstreatment4completed
NCT02891850
Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapyNo drug interventionstreatment4completed
NCT01795950
Safety Study of PLX-PAD Cells to Treat Pulmonary Arterial Hypertension (PAH)No drug interventionstreatment1terminated
NCT03833323
Implantable System for Remodulin Post-Approval StudyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00566423
Biomarkers in the Diagnosis and Assessment of Pulmonary Arterial Hypertension (PAH)No drug interventionsdiagnosticNot Availablecompleted
NCT01757808
A Study of Ranolazine Acute Administration and Short Term Administration in Pulmonary Arterial HypertensionNo drug interventionstreatment1completed
NCT04896008
A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH)No drug interventionstreatment3active_not_recruiting
NCT06454838
Exercise Capacity Muscle Oxygenation and Arterial Stiffness in Children With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01417338
Registry for Pulmonary Hypertension in ChinaNo drug interventionsNot AvailableNot Availableunknown_status
NCT04130243
Biomarkers in Pediatric Congenital Heart Disease and PAHNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01953965
Look at Way the Heart Functions in People With Pulmonary Hypertension (PH) Who Have Near Normal Right Ventricle (RV) Function and People With Pulmonary Hypertension Who Have Impaired RV Function. Using Imaging Studies PET Scan and Cardiac MRI.diagnostic2terminated
NCT01247805
A Pivotal Bioequivalence Study Between The Sildenafil Powder For Oral Suspension (10 Mg/Ml) And The Sildenafil 10 Mg Immediate Release (IR) Tablet Relative To The Revatio 20 Mg IR Tablet In Healthy Volunteers Under Fasting ConditionsNo drug interventionstreatment1completed
NCT05731492
A Study of Macitentan in Children Below 2 Years of AgeNo drug interventionsbasic_science1withdrawn
NCT05996302
HA Residents With PVD, 6MWD Assessed at HA (2840m) vs LA (Sea Level)No drug interventionssupportive_careNot Availableactive_not_recruiting
NCT06429579
Potts-shunt for the Treatment of Pediatric Patients With Severe Pulmonary HypertensionNo drug interventionstreatmentNot Availablerecruiting
NCT04456998
GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)treatment2completed
NCT00502398
Is There Intravascular Hemolysis in Patients With Pulmonary Hypertension?No drug interventionsNot AvailableNot Availableunknown_status
NCT06035861
Endothelial Cell Activation and Total Pulmonary Resistance in PAHbasic_scienceNot Availablenot_yet_recruiting
NCT04610788
Cardiac Assessment by PV Loop in IPAH and Scleroderma PAHNo drug interventionsNot AvailableNot Availablerecruiting
NCT05056532
Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT04194632
Right Ventricular Pacing in Pulmonary Arterial HypertensionNo drug interventionstreatmentNot Availableunknown_status
NCT06122922
Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN)No drug interventionsdiagnostic2withdrawn
NCT06544148
Non-Invasive Measurements of Changes in Pulmonary Artery Pressure in Intensive Care Unit Patients Using Electrical Impedance Tomography - A Feasibility StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06003244
High Altitude (HA) Residents With Pulmonary Vascular Diseases (PVD), 6 Minute Walk Distance (6MWD) Assessed at 2840m (HA) With and Without Supplemental Oxygen Therapy (SOT)No drug interventionsotherNot Availableactive_not_recruiting
NCT03198910
Retrospective Data Analysis of Data From the Zurich PH RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT03195543
Assessment of Blood Coagulation Disorders in Patients With Pulmonary HypertensionNo drug interventionsNot AvailableNot Availableunknown_status
NCT03189602
Pulmonary Artery Involvement in Takayasu's ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT04337671
Impact of Aerobic Training on Sleep Quality and Aerobic Fitness in Male Patients With Pulmonary Artery HypertensionNo drug interventionssupportive_careNot Availablecompleted
NCT06084559
HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)No drug interventionsotherNot Availableactive_not_recruiting
NCT05421949
Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAHNo drug interventionsNot AvailableNot Availablecompleted
NCT06072417
HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level)No drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03617458
Interventions Against Insulin Resistance in Pulmonary Arterial HypertensionNo drug interventionstreatment2active_not_recruiting
NCT03138863
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)No drug interventionstreatmentNot Availablerecruiting
NCT01581086
Vascular Subphenotypes of Lung Disease in HIV & COPDNo drug interventionsNot AvailableNot Availablecompleted
NCT02684786
A Study of Stellate Ganglion Block and / or Reserpine in Group 2 Pulmonary HypertensionNo drug interventionstreatment1withdrawn
NCT02966665
: Vascular Function in Health and DiseaseNo drug interventionsbasic_science1recruiting
NCT03979482
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAHNo drug interventionsNot AvailableNot Availablecompleted
NCT03152773
Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive GuidewiresNo drug interventionsdiagnosticNot Availablerecruiting
NCT04094272
Pulmonary Arterial Hypertension in Patients With Direct-Acting Antiviral Medications for Hepatitis C Virus InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT02102672
Trimetazidine in Pulmonary Artery HypertensionNo drug interventionstreatment2unknown_status
NCT01763112
Training With Whole Body Vibration Device in Patients With PAHNo drug interventionstreatmentNot Availableunknown_status
NCT06258850
REstoration of VItamin D in Pulmonary Arterial HypertensionNo drug interventionstreatment4not_yet_recruiting
NCT05339152
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic HerniaNo drug interventionstreatmentNot Availablenot_yet_recruiting