Skin and skin structure infections (DBCOND0023864)

Identifiers

Synonyms

Skin Structures and Soft Tissue Infections / Skin and skin-structure infections

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amoxicillin	A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Cytochrome P450 2C8enzyme Albumincarrier Beta-lactamase 2enzyme Penicillin binding proteintarget
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Cephalexin	A first generation cephalosporin used to treat certain susceptible bacterial infections.	Albumincarrier Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 1transporter Penicillin-binding protein 3target Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Clavulanic acid	A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.	Bacterial beta-lactamase enzymestarget Sodium/glucose cotransporter 1transporter Beta-lactamasetarget
Erythromycin	A macrolide antibiotic used to treat and prevent a variety of bacterial infections.	23S ribosomal RNAtarget Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Motilin receptortarget Voltage-gated inwardly rectifying potassium channel KCNH2target Cytochrome P450 3A5enzyme Solute carrier organic anion transporter family member 1B3transporter Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Oritavancin	An antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria.	Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Peptidoglycan precursorstarget Bacterial cell wall peptide bridging segmentstarget Pentaglycyl bridging segmenttarget Dihydropteroate synthasetarget
Piperacillin	A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.	Solute carrier family 22 member 6transporter Penicillin-binding protein 3target Penicillin-binding protein 2Btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Organic anion transporter 3transporter
Tosylchloramide	A chlorinated disinfectant of the genitals and injured skin.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT02600611	Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1	Iclaprim Vancomycin	treatment	3	completed
NCT02607618	Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-2	Iclaprim Vancomycin	treatment	3	completed
NCT00876850	Phase 3 Study - Safety and Efficacy of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI)	Linezolid Moxifloxacin Omadacycline	treatment	3	withdrawn
NCT01984684	Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections	Aztreonam Delafloxacin Vancomycin	treatment	3	completed
NCT02863874	The PLUS Study: Comparison of VicrylPlus® Versus Vicryl® for Repair of Perineal Tears	No drug interventions	prevention	Not Available	completed
NCT02877927	Oral Omadacycline vs. Oral Linezolid for the Treatment of ABSSSI	Linezolid Omadacycline	treatment	3	completed
NCT02378480	Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23)	Linezolid Omadacycline	treatment	3	completed