Intraabdominal Infections (DBCOND0046593)

Identifiers

Synonyms

Intra Abdominal Infections / Infection, Intra-abdominal / Intra abdominal infection / Intra-Abdominal Infections / Intra-Abdominal Infection / Abdominal infection / Infectious disease of abdomen (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amikacin	An aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.	30S ribosomal protein S12target
Aztreonam	A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.	Penicillin-binding protein 3target Beta-lactamasetarget Beta-lactamase Toho-1target Peptidoglycan synthase FtsItarget
Cefoperazone	A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts.	Albumincarrier Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget
Cefotetan	An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections.	Albumincarrier Penicillin-binding protein 3target
Cefoxitin	A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Peptidoglycan synthase FtsItarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine endopeptidasetarget Beta-lactamaseenzyme Penicillin-binding protein 3target Penicillin-binding protein 1btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Ceftriaxone	A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.	Albumincarrier Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Penicillin-binding protein 2Btarget Glutamine synthetaseenzyme Solute carrier family 22 member 11target Solute carrier family 22 member 6target Organic anion transporter 3target Solute carrier family 15 member 1target ATP-dependent translocase ABCB1transporter
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Clavulanic acid	A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.	Bacterial beta-lactamase enzymestarget Sodium/glucose cotransporter 1transporter Beta-lactamasetarget
Eravacycline	A tetracycline antibiotic used to treat complicated intra-abdominal infections.	Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme 30S ribosomal protein S4target
Imipenem	A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 3target Dipeptidase 1enzyme Penicillin-binding protein 4target Beta-lactamase SHV-1enzyme Beta-lactamase TEMenzyme Beta-lactamase CTX-Menzyme Beta-lactamaseenzyme Beta-lactamasetarget
Piperacillin	A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.	Solute carrier family 22 member 6transporter Penicillin-binding protein 3target Penicillin-binding protein 2Btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Organic anion transporter 3transporter
Sulbactam	An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.	Beta-lactamasetarget Solute carrier family 22 member 6transporter
Technetium Tc-99m exametazime	A radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.	No drug targets
Tobramycin	An aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections.	16S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget 23S ribosomal RNAtarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02979951	Fosfomycin i.v. for Treatment of Severely Infected Patients	No drug interventions	Not Available	Not Available	recruiting
NCT03482245	The Role of Circadian Clock Proteins in Innate and Adaptive Immunity	No drug interventions	basic_science	Not Available	recruiting
NCT02831556	Point of Care 3D Ultrasound for Various Applications: A Pilot Study	No drug interventions	Not Available	Not Available	completed
NCT04612413	A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients	Allocetra	treatment	2	active_not_recruiting
NCT03744741	HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study	No drug interventions	Not Available	Not Available	completed
NCT01763008	A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections	No drug interventions	Not Available	Not Available	completed
NCT03544203	Multicentre Observational Study on Community Acquired Intraabdominal Infections Management	No drug interventions	Not Available	Not Available	completed
NCT04700787	Safety, Tolerability, and Pharmacokinetics of Sulopenem in Adolescents	No drug interventions	treatment	1	withdrawn
NCT03862378	Prediction of Intra-abdominal Infectious Complication by Drainage Fluid Analysis	No drug interventions	Not Available	Not Available	unknown_status
NCT01069900	Moxifloxacin in Pediatric Subjects With Complicated Intra-abdominal Infection	No drug interventions	treatment	3	completed
NCT03061500	Prognostic Value of Proadrenomedullin in Intra-abdominal Sepsis	No drug interventions	Not Available	Not Available	unknown_status
NCT03358576	Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI)	Amoxicillin Ciprofloxacin Clavulanic acid Ertapenem Metronidazole Probenecid Sulopenem Sulopenem etzadroxil	treatment	3	completed
NCT03997929	Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)	No drug interventions	Not Available	Not Available	completed
NCT00769171	Dragon Study (the Safety and Efficacy for Treatment of Patients With Complicated Intra Abdominal Infections)	No drug interventions	treatment	3	completed
NCT06304779	The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI	No drug interventions	prevention	Not Available	active_not_recruiting
NCT00481702	A Study to Evaluate the Safety and Effectiveness of Ertapenem Versus Ceftriaxone/Metronidazole in the Treatment of Intra-abdominal Infections in Adults (0826-802)	No drug interventions	treatment	3	completed
NCT04519086	The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30	No drug interventions	diagnostic	Not Available	suspended
NCT00952796	A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections	Ampicillin Moxifloxacin Sulbactam	treatment	4	completed
NCT00488345	Study Evaluating the Pharmacokinetics (PK), Safety, and Tolerability of Tigecycline in Patients 8 to 11 Years of Age	No drug interventions	treatment	2	completed
NCT04882085	Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults	No drug interventions	treatment	4	completed
NCT04229511	Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT05127109	The PASTDUe Nutrition Ecosystem Project (PASTDUe)	No drug interventions	treatment	4	recruiting
NCT05187871	Study for Rapid Diagnosis of Postoperative Abdominal Infection	No drug interventions	Not Available	Not Available	unknown_status
NCT02739997	Study of Ceftolozane/Tazobactam (MK-7625A) in Combination With Metronidazole in Japanese Participants With Complicated Intra-abdominal Infection (MK-7625A-013)	No drug interventions	treatment	3	completed
NCT01561066	Autologous Fibrin Glues for Fistulas Closure	Octreotide	treatment	1	completed
NCT00630513	T.E.A. Study Three Days Ertapenem Versus Three Days Ampicillin- Sulbactam	No drug interventions	treatment	4	completed
NCT00244088	Study Evaluating the Etiology of Intra-Abdominal Infections	No drug interventions	Not Available	Not Available	completed
NCT00230971	Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)	Ceftriaxone Metronidazole Tigecycline	treatment	4	completed
NCT06507423	Performance of the SeptiCyte LAB Test for Antibiotic Stewardship in Mesenteric Ischemia	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05549076	Hellenic Registry for cIAIs (HERCO-II)	No drug interventions	Not Available	Not Available	completed
NCT02533869	The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis	No drug interventions	diagnostic	Not Available	completed
NCT01721408	A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection	No drug interventions	treatment	4	completed
NCT00621192	Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections	No drug interventions	treatment	1 / 2	completed
NCT03354754	LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Intra-abdominal Infection (cIAI)	No drug interventions	basic_science	2	terminated
NCT01789905	Tygacil Drug Use Investigation	Tigecycline	Not Available	Not Available	completed
NCT05628493	Gut Microbiota Analysis in IAI Patients With Sepsis-associated Liver Dysfunction	No drug interventions	Not Available	Not Available	completed
NCT01506271	Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)	Cilastatin Imipenem Relebactam	treatment	2	completed
NCT04240288	Procalcitonin Guided Antibiotic Therapy	No drug interventions	other	Not Available	withdrawn
NCT01473836	A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection	Ceftriaxone Metronidazole	treatment	3	completed
NCT04094818	HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis	No drug interventions	Not Available	Not Available	recruiting
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT00827541	Post-Authorization Study Evaluating Safety Of Tigecycline	No drug interventions	Not Available	Not Available	completed
NCT02442596	Abdominal SepsiS Study: Epidemiology of Etiology and Outcome	No drug interventions	Not Available	Not Available	completed
NCT00965848	A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections	No drug interventions	treatment	4	completed
NCT05639504	Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED)	No drug interventions	Not Available	Not Available	withdrawn