Severe, active Rheumatoid arthritis

DrugDrug NameDrug Description
DB11817BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB06674GolimumabA TNF╬▒ inhibitor used in the symptomatic treatment of various active inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
DB11767SarilumabA monoclonal antibody used to treat moderate to severe rheumatoid arthritis who have responded poorly or are intolerant of other DMARDs.
DB06273TocilizumabAn interleukin-6 (IL-6) receptor antagonist used to treat Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA).
DrugDrug NameTargetType
DB11817BaricitinibSolute carrier family 22 member 8transporter
DB11817BaricitinibATP-binding cassette sub-family G member 2transporter
DB11817BaricitinibMultidrug and toxin extrusion protein 2transporter
DB11817BaricitinibCytochrome P450 3A4enzyme
DB11817BaricitinibTyrosine-protein kinase JAK1target
DB11817BaricitinibTyrosine-protein kinase JAK2target
DB11817BaricitinibSolute carrier family 22 member 6transporter
DB11817BaricitinibSolute carrier family 22 member 2transporter
DB11817BaricitinibSolute carrier organic anion transporter family member 1B3transporter
DB11817BaricitinibTyrosine-protein kinase JAK3target
DB11817BaricitinibP-glycoprotein 1transporter
DB11817BaricitinibNon-receptor tyrosine-protein kinase TYK2target
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineP-glycoprotein 1transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB06674GolimumabTumor necrosis factortarget
DB11767SarilumabCytochrome P450 3A4enzyme
DB11767SarilumabInterleukin-6 receptor subunit alphatarget
DB11767SarilumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB06273TocilizumabInterleukin-6 receptor subunit alphatarget
DB06273TocilizumabCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount