Cushing's Syndrome (DBCOND0028130)

Identifiers

Synonyms
Cushing s Syndrome / Cushing Syndrome / Cushing’s syndrome / Cushing's syndrome / Cushings syndrome / Cushing's syndrome, unspecified / Syndrome Cushing's / Hypercortisolism (disorder) / Adrenal Cushing's syndrome (disorder) / Hypercorticoidism / Hyperadrenalcorticalism / Hyperadrenocorticalism / Hypercortisolaemia / Adrenal cortical hyperfunctions / Adrenal cortex hyperfunction / Hyperadrenalism / Hyperadrenocorticism / Adrenocortical Hyperfunction / Hypercortisolemia / Adrenocortical hyperfunction (disorder) / Hypercortisolism / Hypercortisonism / Adrenal hypercorticism / Hypercorticism adrenal

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cortisone acetate
A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.
Dexamethasone
A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
Mitotane
An adrenal cortex inhibitor used to treat adrenocortical tumors and Cushing's syndrome.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06246357
Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolismdiagnostic2recruiting
NCT06573723
Institutional Registry of Rare DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT06008184
Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological FluidsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05347979
Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participantstreatment1completed
NCT02001051
Study of Adrenalectomy Versus Observation for Subclinical HypercortisolismNo drug interventionstreatment2terminated
NCT06326853
Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical ModelsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02791698
The Accuracy of Late Night Urinary Free Cortisol/Creatinine and Hair Cortisol in Cushing's Syndrome DiagnosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05456997
Metabolic Myopathy in EndocrinopathyNo drug interventionsNot AvailableNot Availableterminated
NCT02543697
Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal TumorsNo drug interventionsdiagnosticNot Availableunknown_status
NCT03673761
Muscle in Acromegaly and Cushing's SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT03697109
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrometreatment3completed
NCT04045015
Liquorice and Salivary CortisolNo drug interventionsdiagnosticNot Availableunknown_status
NCT03474237
A Prospective Cohort Study for Patients With Adrenal DiseasesNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03343470
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)No drug interventionsNot AvailableNot Availablerecruiting
NCT02934399
Dynamic Hormone Diagnostics in Endocrine DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT06250699
A Single Center Randomized Controlled Study on the Promotion of Rapid RecoveryNo drug interventionstreatmentNot Availablerecruiting
NCT04433819
Nailfold Capillaroscopy Evaluation in Cushing Syndrome PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00081341
Cognition, Steroids, and Imaging in Cushings DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03379363
Retrospective Chart Review Study of Pediatric Patients Treated With Korlym for Cushing SyndromeNo drug interventionsNot AvailableNot Availableterminated
NCT00669266
Adrenal Tumors - Pathogenesis and TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01382420
Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal IncidentalomaNo drug interventionstreatmentNot Availableunknown_status
NCT04872920
Observational Registry on Patients With Endogenous CS to Document Safety and Effectiveness of Ketoconazole.No drug interventionsNot AvailableNot Availableunknown_status
NCT02618694
Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative StudyNo drug interventionstreatmentNot Availablecompleted
NCT05521529
Cushing's Syndrome Before and After Treatment (CORRECT)No drug interventionsNot AvailableNot Availablerecruiting
NCT04890444
China Adrenal Disease RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT05804669
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's SyndromeNo drug interventionstreatment1 / 2recruiting
NCT03364803
Collecting Information About Treatment Results for Patients With Cushing's SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT04374721
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersNo drug interventionsotherNot Availablerecruiting
NCT05568602
Appropriate Limit Value for 1 mg DST in Patients With Chronic Renal FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04543253
Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS)No drug interventionsNot AvailableNot Availablerecruiting
NCT03604198
Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrometreatment2enrolling_by_invitation
NCT06229405
Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World DataNo drug interventionsNot AvailableNot Availablerecruiting
NCT05881005
NAC- NAFLD and CushingNo drug interventionsdiagnosticNot Availablerecruiting
NCT03053271
A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrometreatment2terminated
NCT03145285
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinomatreatment2unknown_status
NCT00029952
Long Term Post Operative Follow-Up of Cushing SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00001849
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndromediagnostic2completed
NCT03211624
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT06050057
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted AdrenalectomyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05911620
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous HypercorticismNo drug interventionsdiagnosticNot Availablerecruiting
NCT03621280
Open-label Treatment in Cushing's Syndrometreatment3completed
NCT03229395
Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by GlucocorticoidsNo drug interventionsNot AvailableNot Availablecompleted
NCT05633953
Osilodrostat for the Treatment of Non-Cushing's Disease Cushing's SyndromeNot AvailableNot Availablecompleted
NCT00682084
Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's SyndromeNo drug interventionsNot AvailableNot Availableterminated
NCT00457587
Preclinical Study Towards an Immunotherapy in Adrenocortical CarcinomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00361777
Diagnostic Performance of Screening Tests for Cushing s SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT02297945
Effects of Metyrapone in Patients With Endogenous Cushing's Syndrometreatment3completed
NCT02663609
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00001452
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney ComplexNo drug interventionsNot AvailableNot Availablecompleted
NCT00004334
Study of Depression, Peptides, and Steroids in Cushing's SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT02922257
Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT00004326
Hippocampal Complex Volume and Memory Dysfunction in Cushing's SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00422201
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretiontreatment2terminated
NCT01504555
Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?No drug interventionsNot AvailableNot Availableunknown_status
NCT03606408
Roll-over Study in Patients With Endogenous Cushing's Syndrome for LCI699treatment2completed
NCT00004343
Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT00001453
Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00796783
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of HypercortisolemiaNo drug interventionsNot AvailableNot Availableterminated
NCT01959711
Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyNo drug interventionstreatment4completed
NCT02468193
Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrometreatment2completed
NCT00006278
Study of Cushing's Syndrome Not Related to ACTH ProductionNo drug interventionsNot AvailableNot Availablecompleted
NCT02019706
Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndromediagnostic2recruiting
NCT00936741
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrometreatment3completed
NCT02889224
In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in ManNo drug interventionsotherNot Availablecompleted
NCT01371565
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrometreatment3completed
NCT00569582
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrometreatment3completed
NCT00001180
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal InsufficiencyNot AvailableNot Availablecompleted
NCT03817840
Novel Mediators of the Lipodystrophy and Metabolic Consequences of Cushing's DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02804750
Study to Evaluate CORT125134 in Participants With Cushing's Syndrometreatment2completed
NCT00088608
A Study to Assess SOM230 in Patients With Pituitary Cushing's Diseasetreatment2completed
NCT02646553
Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children.No drug interventionsNot AvailableNot Availableunknown_status