Bile salt export pump
Details
- Name
- Bile salt export pump
- Synonyms
- 7.6.2.-
- ATP-binding cassette sub-family B member 11
- BSEP
- Gene Name
- ABCB11
- UniProtKB Entry
- O95342Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010492|Bile salt export pump MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLV QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI S
- Number of residues
- 1321
- Molecular Weight
- 146405.83
- Theoretical pI
- 6.52
- GO Classification
- FunctionsABC-type bile acid transporter activity / ABC-type xenobiotic transporter activity / ATP hydrolysis activity / bile acid transmembrane transporter activity / carbohydrate transmembrane transporter activityProcessesbile acid signaling pathway / cholesterol homeostasis / fatty acid metabolic process / lipid homeostasis / phospholipid homeostasis / positive regulation of bile acid secretion / protein ubiquitination / regulation of bile acid metabolic process / regulation of fatty acid beta-oxidation / response to estrogen / response to ethanol / response to organic cyclic compound / response to oxidative stress / transmembrane transport / xenobiotic export from cell / xenobiotic metabolic process / xenobiotic transmembrane transportComponentsapical plasma membrane / cell surface / endosome / Golgi membrane / intracellular canaliculus / recycling endosome / recycling endosome membrane
- General Function
- Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:15791618, PubMed:16332456, PubMed:18985798, PubMed:19228692, PubMed:20010382, PubMed:20398791, PubMed:22262466, PubMed:24711118, PubMed:29507376, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269)
- Specific Function
- Abc-type bile acid transporter activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 63-83 148-168 216-236 241-261 320-340 354-374 756-776 795-815 870-890 891-911 980-1000 1012-1032
- Cellular Location
- Apical cell membrane
- Gene sequence
>lcl|BSEQ0010493|Bile salt export pump (ABCB11) ATGTCTGACTCAGTAATTCTTCGAAGTATAAAGAAATTTGGAGAGGAGAATGATGGTTTT GAGTCAGATAAATCATATAATAATGATAAGAAATCAAGGTTACAAGATGAGAAGAAAGGT GATGGCGTTAGAGTTGGCTTCTTTCAATTGTTTCGGTTTTCTTCATCAACTGACATTTGG CTGATGTTTGTGGGAAGTTTGTGTGCATTTCTCCATGGAATAGCCCAGCCAGGCGTGCTA CTCATTTTTGGCACAATGACAGATGTTTTTATTGACTACGACGTTGAGTTACAAGAACTC CAGATTCCAGGAAAAGCATGTGTGAATAACACCATTGTATGGACTAACAGTTCCCTCAAC CAGAACATGACAAATGGAACACGTTGTGGGTTGCTGAACATCGAGAGCGAAATGATCAAA TTTGCCAGTTACTATGCTGGAATTGCTGTCGCAGTACTTATCACAGGATATATTCAAATA TGCTTTTGGGTCATTGCCGCAGCTCGTCAGATACAGAAAATGAGAAAATTTTACTTTAGG AGAATAATGAGAATGGAAATAGGGTGGTTTGACTGCAATTCAGTGGGGGAGCTGAATACA AGATTCTCTGATGATATTAATAAAATCAATGATGCCATAGCTGACCAAATGGCCCTTTTC ATTCAGCGCATGACCTCGACCATCTGTGGTTTCCTGTTGGGATTTTTCAGGGGTTGGAAA CTGACCTTGGTTATTATTTCTGTCAGCCCTCTCATTGGGATTGGAGCAGCCACCATTGGT CTGAGTGTGTCCAAGTTTACGGACTATGAGCTGAAGGCCTATGCCAAAGCAGGGGTGGTG GCTGATGAAGTCATTTCATCAATGAGAACAGTGGCTGCTTTTGGTGGTGAGAAAAGAGAG GTTGAAAGGTATGAGAAAAATCTTGTGTTCGCCCAGCGTTGGGGAATTAGAAAAGGAATA GTGATGGGATTCTTTACTGGATTCGTGTGGTGTCTCATCTTTTTGTGTTATGCACTGGCC TTCTGGTACGGCTCCACACTTGTCCTGGATGAAGGAGAATATACACCAGGAACCCTTGTC CAGATTTTCCTCAGTGTCATAGTAGGAGCTTTAAATCTTGGCAATGCCTCTCCTTGTTTG GAAGCCTTTGCAACTGGACGTGCAGCAGCCACCAGCATTTTTGAGACAATAGACAGGAAA CCCATCATTGACTGCATGTCAGAAGATGGTTACAAGTTGGATCGAATCAAGGGTGAAATT GAATTCCATAATGTGACCTTCCATTATCCTTCCAGACCAGAGGTGAAGATTCTAAATGAC CTCAACATGGTCATTAAACCAGGGGAAATGACAGCTCTGGTAGGACCCAGTGGAGCTGGA AAAAGTACAGCACTGCAACTCATTCAGCGATTCTATGACCCCTGTGAAGGAATGGTGACC GTGGATGGCCATGACATTCGCTCTCTTAACATTCAGTGGCTTAGAGATCAGATTGGGATA GTGGAGCAAGAGCCAGTTCTGTTCTCTACCACCATTGCAGAAAATATTCGCTATGGCAGA GAAGATGCAACAATGGAAGACATAGTCCAAGCTGCCAAGGAGGCCAATGCCTACAACTTC ATCATGGACCTGCCACAGCAATTTGACACCCTTGTTGGAGAAGGAGGAGGCCAGATGAGT GGTGGCCAGAAACAAAGGGTAGCTATCGCCAGAGCCCTCATCCGAAATCCCAAGATTCTG CTTTTGGACATGGCCACCTCAGCTCTGGACAATGAGAGTGAAGCCATGGTGCAAGAAGTG CTGAGTAAGATTCAGCATGGGCACACAATCATTTCAGTTGCTCATCGCTTGTCTACGGTC AGAGCTGCAGATACCATCATTGGTTTTGAACATGGCACTGCAGTGGAAAGAGGGACCCAT GAAGAATTACTGGAAAGGAAAGGTGTTTACTTCACTCTAGTGACTTTGCAAAGCCAGGGA AATCAAGCTCTTAATGAAGAGGACATAAAGGATGCAACTGAAGATGACATGCTTGCGAGG ACCTTTAGCAGAGGGAGCTACCAGGATAGTTTAAGGGCTTCCATCCGGCAACGCTCCAAG TCTCAGCTTTCTTACCTGGTGCACGAACCTCCATTAGCTGTTGTAGATCATAAGTCTACC TATGAAGAAGATAGAAAGGACAAGGACATTCCTGTGCAGGAAGAAGTTGAACCTGCCCCA GTTAGGAGGATTCTGAAATTCAGTGCTCCAGAATGGCCCTACATGCTGGTAGGGTCTGTG GGTGCAGCTGTGAACGGGACAGTCACACCCTTGTATGCCTTTTTATTCAGCCAGATTCTT GGGACTTTTTCAATTCCTGATAAAGAGGAACAAAGGTCACAGATCAATGGTGTGTGCCTA CTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTT GCTAAATCTGGGGAGCTCCTAACAAAAAGGCTACGTAAATTTGGTTTCAGGGCAATGCTG GGGCAAGATATTGCCTGGTTTGATGACCTCAGAAATAGCCCTGGAGCATTGACAACAAGA CTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTC AATTCCTTCACTAACGTCACTGTGGCCATGATCATTGCCTTCTCCTTTAGCTGGAAGCTG AGCCTGGTCATCTTGTGCTTCTTCCCCTTCTTGGCTTTATCAGGAGCCACACAGACCAGG ATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACA AATGAAGCCCTCAGTAACATCCGCACTGTTGCTGGAATTGGAAAGGAGAGGCGGTTCATT GAAGCACTTGAGACTGAGCTGGAGAAGCCCTTCAAGACAGCCATTCAGAAAGCCAATATT TACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTAC AGATATGGAGGTTACTTAATCTCCAATGAGGGGCTCCATTTCAGCTATGTGTTCAGGGTG ATCTCTGCAGTTGTACTGAGTGCAACAGCTCTTGGAAGAGCCTTCTCTTACACCCCAAGT TATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCA ATCAGTGTATACAATACTGCAGGTGAAAAATGGGACAACTTCCAGGGGAAGATTGATTTT GTTGATTGTAAATTTACATATCCTTCTCGACCTGACTCGCAAGTTCTGAATGGTCTCTCA GTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGC ACTAGCATTCAGCTGTTGGAACGTTTCTATGATCCTGATCAAGGGAAGGTGATGATAGAT GGTCATGACAGCAAAAAAGTAAATGTCCAGTTCCTCCGCTCAAACATTGGAATTGTTTCC CAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACC AAAGAAATTCCCATGGAAAGAGTCATAGCAGCTGCAAAACAGGCTCAGCTGCATGATTTT GTCATGTCACTCCCAGAGAAATATGAAACTAACGTTGGGTCCCAGGGGTCTCAACTCTCT AGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTG CTACTAGATGAAGCCACTTCTGCCTTAGACACAGAAAGTGAAAAGACGGTGCAGGTTGCT CTAGACAAAGCCAGAGAGGGTCGGACCTGCATTGTCATTGCCCATCGCTTGTCCACCATC CAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCAT GAAGAACTGATGGCCCAAAAAGGAGCCTACTACAAACTAGTCACCACTGGATCCCCCATC AGTTGA
- Chromosome Location
- 2
- Locus
- 2q31.1
- External Identifiers
Resource Link UniProtKB ID O95342 UniProtKB Entry Name ABCBB_HUMAN GenBank Protein ID 3873243 GenBank Gene ID AF091582 GeneCard ID ABCB11 GenAtlas ID ABCB11 HGNC ID HGNC:42 PDB ID(s) 6LR0, 7DV5, 7E1A, 8PM6, 8PMD, 8PMJ KEGG ID hsa:8647 IUPHAR/Guide To Pharmacology ID 778 NCBI Gene ID 8647 - General References
- Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Nemeth A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet. 1998 Nov;20(3):233-8. [Article]
- Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
- Mochizuki K, Kagawa T, Numari A, Harris MJ, Itoh J, Watanabe N, Mine T, Arias IM: Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G818-28. Epub 2006 Nov 2. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ, Koning JH, De Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CM, Gouw A, Van Goor H, Thompson RJ, Muller M: Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology. 1999 Dec;117(6):1370-9. [Article]
- Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47(1):38-50. [Article]
- Chen HL, Chang PS, Hsu HC, Ni YH, Hsu HY, Lee JH, Jeng YM, Shau WY, Chang MH: FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels. J Pediatr. 2002 Jan;140(1):119-24. [Article]
- van Mil SW, van der Woerd WL, van der Brugge G, Sturm E, Jansen PL, Bull LN, van den Berg IE, Berger R, Houwen RH, Klomp LW: Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology. 2004 Aug;127(2):379-84. [Article]
- Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA: Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics. 2004 Feb;14(2):91-102. [Article]
- Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Mullhaupt B, Meier PJ, Pauli-Magnus C: Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J Hepatol. 2005 Sep;43(3):536-43. [Article]
- Lang T, Haberl M, Jung D, Drescher A, Schlagenhaufer R, Keil A, Mornhinweg E, Stieger B, Kullak-Ublick GA, Kerb R: Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). Drug Metab Dispos. 2006 Sep;34(9):1582-99. Epub 2006 Jun 8. [Article]
- Meier Y, Pauli-Magnus C, Zanger UM, Klein K, Schaeffeler E, Nussler AK, Nussler N, Eichelbaum M, Meier PJ, Stieger B: Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology. 2006 Jul;44(1):62-74. [Article]
- Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C: Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet Genomics. 2007 Jan;17(1):47-60. [Article]
- Hu G, He P, Liu Z, Chen Q, Zheng B, Zhang Q: Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing. Mol Med Rep. 2014 Sep;10(3):1264-74. doi: 10.3892/mmr.2014.2349. Epub 2014 Jun 20. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Bile salt export pump (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details ATP investigational, nutraceutical unknown target Details Glyburide approved unknown target inhibitor Details Ursodeoxycholic acid approved, investigational unknown transporter substrateinhibitorinducer Details Deoxycholic acid approved unknown transporter inducer Details Taurocholic acid approved, experimental unknown transporter substrateinducer Details Cholic Acid approved unknown transporter substrateinhibitorinducer Details Dexamethasone approved, investigational, vet_approved unknown transporter inducer Details Phenobarbital approved, investigational unknown transporter inducer Details Ethinylestradiol approved unknown transporter inhibitor Details Rifampin approved unknown transporter inhibitor Details Glycochenodeoxycholic Acid experimental unknown transporter substrateinhibitor Details Glyburide approved unknown transporter substrateinhibitor Details Cyclosporine approved, investigational, vet_approved unknown transporter substrateinhibitor Details Reserpine approved, investigational, withdrawn unknown transporter inhibitor Details Vinblastine approved no transporter substrateinhibitor Details Progesterone approved, vet_approved unknown transporter inhibitor Details Ketoconazole approved, investigational unknown transporter inhibitor Details Troglitazone approved, investigational, withdrawn unknown transporter inhibitor Details Paclitaxel approved, vet_approved no transporter substrateinhibitor Details Fusidic acid approved, investigational unknown transporter inhibitor Details Bosentan approved, investigational unknown transporter inhibitor Details Doxorubicin approved, investigational unknown transporter substrate Details Fluorescein approved unknown transporter substrate Details Vincristine approved, investigational unknown transporter substrate Details Digoxin approved unknown transporter substrate Details Pravastatin approved no transporter substrate Details Rosuvastatin approved unknown transporter substrate Details Simeprevir approved unknown transporter inhibitor Details Letermovir approved, investigational unknown transporter inhibitor Details Tipranavir approved, investigational unknown transporter substrateinhibitor Details Clotrimazole approved, vet_approved unknown transporter substrateinhibitor Details Lenvatinib approved, investigational unknown transporter inhibitor Details Telmisartan approved, investigational no transporter substrate Details Indocyanine green acid form approved, investigational no transporter substrate Details Nefazodone approved, withdrawn no transporter substrate Details Saquinavir approved, investigational no transporter substrate Details Lopinavir approved no transporter inhibitor Details Ritonavir approved, investigational no transporter inhibitor Details Mifepristone approved, investigational no transporter substrate Details Loratadine approved, investigational unknown transporter substrate Details Dihydroergocristine approved, experimental no transporter substrate Details Benzbromarone investigational, withdrawn no transporter substrate Details Nicardipine approved, investigational no transporter substrate Details Lovastatin approved, investigational no transporter substrate Details Felodipine approved, investigational no transporter substrate Details Diethylstilbestrol approved, investigational, withdrawn no transporter substrate Details Losartan approved no transporter substrate Details Glimepiride approved no transporter substrate Details Disulfiram approved no transporter substrate Details Simvastatin approved no transporter substrate Details Spironolactone approved no transporter substrate Details Atorvastatin approved no transporter substrate Details Cerivastatin approved, withdrawn no transporter substrate Details Isradipine approved, investigational no transporter substrate Details Ezetimibe approved no transporter substrate Details Dipyridamole approved no transporter substrate Details Pitavastatin approved no transporter substrate Details Fenofibrate approved no transporter substrate Details Atazanavir approved, investigational no transporter substrate Details Repaglinide approved, investigational no transporter substrate Details Sulfinpyrazone approved no transporter substrate Details Ranolazine approved, investigational no transporter substrate Details Rosiglitazone approved, investigational no transporter substrate Details Nelfinavir approved no transporter substrate Details Budesonide approved no transporter substrate Details Indinavir approved no transporter substrate Details Celecoxib approved, investigational no transporter inhibitor Details Cefaclor approved no transporter substrate Details Prasterone sulfate investigational no transporter substrate Details Astemizole approved, withdrawn no transporter substrate Details Amiodarone approved, investigational no transporter substrateinhibitor Details Tinidazole approved, investigational no transporter substrate Details Pilsicainide investigational no transporter substrate Details Nitrofurantoin approved, vet_approved no transporter substrate Details Imatinib approved no transporter substrate Details Indomethacin approved, investigational no transporter substrate Details Fluvoxamine approved, investigational no transporter substrate Details Ofloxacin approved no transporter substrate Details Glipizide approved, investigational no transporter substrate Details Olmesartan approved, investigational no transporter inhibitor Details Atenolol approved no transporter substrate Details Efavirenz approved, investigational no transporter substrate Details Terfenadine approved, withdrawn no transporter substrate Details Clarithromycin approved no transporter substrate Details Glycyrrhizic acid approved, experimental no transporter substrate Details Atropine approved, vet_approved no transporter substrate Details Flucloxacillin approved, investigational no transporter substrate Details Nitrendipine approved, investigational no transporter substrate Details Erythromycin approved, investigational, vet_approved no transporter substrateinhibitor Details Diclofenac approved, vet_approved no transporter substrate Details Nifedipine approved no transporter inhibitor Details Sulfamethoxazole approved no transporter inhibitor Details Naproxen approved, vet_approved no transporter substrate Details Chlorpromazine approved, investigational, vet_approved no transporter inhibitor Details Cimetidine approved, investigational unknown transporter inhibitor Details Quinidine approved, investigational no transporter inhibitor Details Tamoxifen approved no transporter inhibitor Details Valinomycin experimental no transporter inhibitor Details Obeticholic acid approved unknown transporter inhibitorinducer Details Remdesivir approved, investigational unknown transporter inhibitor Details Dexamethasone acetate approved, investigational, vet_approved unknown transporter inducer Details Belantamab mafodotin approved unknown transporter substrate Details Pralsetinib approved, investigational no transporter inhibitor Details Infigratinib approved, investigational no transporter inhibitor Details Brincidofovir approved, investigational no transporter inhibitor Details Avapritinib approved, investigational unknown transporter inhibitor Details Romidepsin approved, investigational no transporter inhibitor Details Tauroursodeoxycholic acid approved, investigational unknown transporter regulator Details Tepotinib approved, investigational no transporter inhibitor Details Palovarotene approved, investigational no transporter inhibitor Details Aprocitentan approved, investigational no transporter inhibitor Details Resmetirom approved, investigational unknown transporter inhibitor Details Ceftobiprole medocaril approved, experimental, investigational no transporter inhibitor Details Ceftobiprole approved, investigational no transporter inhibitor Details Elafibranor approved, investigational unknown transporter inhibitor Details Deuruxolitinib investigational unknown transporter inhibitor Details