Depression Acute (DBCOND0126328)

Identifiers

Synonyms

Acute Depression / Acute depression (disorder) / Major depressive disorder, recurrent, unspecified / Depressive state / Depression NOS / Depressed state / Depression / Depression mental

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Potassium voltage-gated channel subfamily KQT member 2target Alpha-2A adrenergic receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Histamine H1 receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 1Atarget Alpha-1A adrenergic receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Potassium voltage-gated channel subfamily A member 1target Alpha-1D adrenergic receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget High affinity nerve growth factor receptortarget BDNF/NT-3 growth factors receptortarget Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Histamine H2 receptortarget Histamine H4 receptortarget Sigma non-opioid intracellular receptor 1target 5-hydroxytryptamine receptor 2Ctarget Alpha-1B adrenergic receptortarget 5-hydroxytryptamine receptor 7target 5-hydroxytryptamine receptor 1Dtarget Mu-type opioid receptortarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 6target Potassium voltage-gated channel subfamily KQT member 3target UDP-glucuronosyltransferase 2B10enzyme 5-hydroxytryptamine receptor 2Ctarget Muscarinic acetylcholine receptortarget HERG human cardiac K+ channeltarget ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A4enzyme Glutathione S-transferases (Cytosolic)enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04266288	Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department	Ketamine Sodium chloride	treatment	4	completed
NCT02378415	Subanesthetic IV Bolus Ketamine in the Treatment of Acute Depression	Ketamine	treatment	1	terminated
NCT03323073	Study of Functional Networks in Resting fMRI	No drug interventions	health_services_research	Not Available	terminated