Clinically Isolated Syndrome (CIS)

Also known as: Clinically Isolated Syndrome / Clinically Isolated Syndromes / Clinically Isolated System / Clinically isolated syndrome (disorder)

Drug	Drug Name	Drug Description
DB08908	Dimethyl fumarate	A medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB14783	Diroximel fumarate	A drug used for the treatment of relapsing forms of Multiple Sclerosis (MS).
DB08868	Fingolimod	A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
DB05259	Glatiramer	An immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS).
DB11988	Ocrelizumab	A CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
DB06650	Ofatumumab	An anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
DB12612	Ozanimod	A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
DB09122	Peginterferon beta-1a	An interferon beta used to treat relapsing forms of multiple sclerosis.
DB12016	Ponesimod	A sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
DB11850	Ublituximab	A low-fucose CD20-targeted monoclonal antibody used in the treatment of relapsing forms of multiple sclerosis.

Drug	Drug Name	Target	Type
DB08908	Dimethyl fumarate	Kelch-like ECH-associated protein 1	target
DB08908	Dimethyl fumarate	Transcription factor p65	target
DB14783	Diroximel fumarate	Neuronal acetylcholine receptor subunit alpha-10	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 5	target
DB08868	Fingolimod	Sphingosine kinase 1	enzyme
DB08868	Fingolimod	Cytochrome P450 2E1	enzyme
DB08868	Fingolimod	Leukotriene-B(4) omega-hydroxylase 1	enzyme
DB08868	Fingolimod	Histone deacetylase 1	target
DB08868	Fingolimod	Excitatory amino acid transporter 2	transporter
DB08868	Fingolimod	Excitatory amino acid transporter 1	transporter
DB08868	Fingolimod	P-glycoprotein 1	transporter
DB08868	Fingolimod	Multidrug resistance-associated protein 1	transporter
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 1	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 4	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 3	target
DB05259	Glatiramer	HLA class II histocompatibility antigen, DRB1-1 beta chain	target
DB05259	Glatiramer	HLA class II histocompatibility antigen, DRB1-15 beta chain	target
DB05259	Glatiramer	HLA class II histocompatibility antigen, DRB1-4 beta chain	target
DB11988	Ocrelizumab	B-lymphocyte antigen CD20	target
DB06650	Ofatumumab	B-lymphocyte antigen CD20	target
DB12612	Ozanimod	Sphingosine 1-phosphate receptor 1	target
DB12612	Ozanimod	Sphingosine 1-phosphate receptor 5	target
DB12612	Ozanimod	Amine oxidase [flavin-containing] B	transporter
DB12612	Ozanimod	ATP-binding cassette sub-family G member 2	transporter
DB12612	Ozanimod	P-glycoprotein 1	transporter
DB12612	Ozanimod	Fatty aldehyde dehydrogenase	enzyme
DB12612	Ozanimod	Alcohol dehydrogenase class-3	enzyme
DB12612	Ozanimod	Arylamine N-acetyltransferase 2	enzyme
DB12612	Ozanimod	Cytochrome P450 2C8	enzyme
DB12612	Ozanimod	Amine oxidase [flavin-containing] B	enzyme
DB12612	Ozanimod	Aldo-keto reductase family 1 member C1	enzyme
DB12612	Ozanimod	Aldo-keto reductase family 1 member C2	enzyme
DB12612	Ozanimod	Cytochrome P450 3A4	enzyme
DB09122	Peginterferon beta-1a	Cytochrome P450 1A2	enzyme
DB09122	Peginterferon beta-1a	Interferon alpha/beta receptor 1	target
DB12016	Ponesimod	Sphingosine 1-phosphate receptor 1	target
DB12016	Ponesimod	Cytochrome P450 2J2	enzyme
DB12016	Ponesimod	Cytochrome P450 3A4	enzyme
DB12016	Ponesimod	Cytochrome P450 3A5	enzyme
DB12016	Ponesimod	Cytochrome P450 4F3	enzyme
DB12016	Ponesimod	Cytochrome P450 4F12	enzyme
DB12016	Ponesimod	UDP-glucuronosyltransferase 1-1	enzyme
DB12016	Ponesimod	UDP-glucuronosyltransferase 2B7	enzyme
DB11850	Ublituximab	B-lymphocyte antigen CD20	target

Drug	Drug Name	Phase	Status	Count
DB00959	Methylprednisolone	2	Terminated	1
DB14644	Methylprednisolone hemisuccinate	2	Terminated	1
DB14631	Prednisolone phosphate	2	Terminated	1
DB00060	Interferon beta-1a	3	Completed	2
DB01017	Minocycline	3	Completed	1
DB01017	Minocycline	3	Terminated	1
DB00060	Interferon beta-1a	4	Completed	1
DB11988	Ocrelizumab	4	Active Not Recruiting	3
DB00068	Interferon beta-1b	Not Available	Completed	1
DB11988	Ocrelizumab	Not Available	Completed	1