Induction of anesthesia therapy (DBCOND0024330)

Identifiers

Synonyms

Induction of Anesthesia / Anaesthetic induction / Anesthetic induction / Induction of anaesthesia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alfentanil	An opioid agonist used to induce and maintain anesthesia, as well as an analgesic.	Mu-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier Albumincarrier Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter
Fentanyl	An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.	Mu-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Kappa-type opioid receptortarget ATP-dependent translocase ABCB1target Albumincarrier alpha1-acid glycoproteincarrier
Glycopyrronium	An anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M2target Cytochrome P450 2D6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Albumincarrier alpha1-acid glycoproteincarrier
Methohexital	An anesthetic used to induce deep sedation.	Gamma-aminobutyric acid receptor subunit alpha-1target
Propofol	A medication used in general anesthesia and for sedation.	Cytochrome P450 2B6enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A9enzyme Gamma-aminobutyric acid receptor subunit beta-2target Gamma-aminobutyric acid receptor subunit beta-3target Albumincarrier Sodium channel protein type 4 subunit alphatarget Sodium channel protein type 2 subunit alphatarget Fatty-acid amide hydrolase 1enzyme Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1-6enzyme GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04208984	Diversion Device With Breath Control	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03808844	A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of General Anesthesia in Elective Surgery Subjects	HSK-3486 Propofol	treatment	3	completed
NCT02999126	Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance	Propofol Remifentanil	diagnostic	4	unknown_status
NCT05166330	Two Ratios of Propofol-ketamine Admixture for Rapid-sequence Induction Anesthesia for Emergency Laparotomy	No drug interventions	prevention	4	unknown_status
NCT05429086	Explore the Advantages of Remimazolam Used on Gastroscopy	Propofol Remimazolam	prevention	4	unknown_status