Clinically Isolated Syndrome (CIS) (DBCOND0062611)

Identifiers

Synonyms
Clinically Isolated Syndrome / Clinically Isolated Syndromes / Clinically Isolated System / Clinically isolated syndrome (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Dimethyl fumarate
A medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
Diroximel fumarate
A drug used for the treatment of relapsing forms of Multiple Sclerosis (MS).
Fingolimod
A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
Glatiramer
An immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS).
Ocrelizumab
A CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
Ofatumumab
An anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
Ozanimod
A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
Peginterferon beta-1a
An interferon beta used to treat relapsing forms of multiple sclerosis.
Ponesimod
A sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
Ublituximab
A low-fucose CD20-targeted monoclonal antibody used in the treatment of relapsing forms of multiple sclerosis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02549703
Mitochondrial Dysfunction and Disease ProgressionNo drug interventionsNot AvailableNot Availablecompleted
NCT01039103
Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)Not Available2terminated
NCT04798651
Pathogenicity of B and CD4 T Cell Subsets in Multiple SclerosisNo drug interventionsotherNot Availablerecruiting
NCT03872583
Understanding Magnetic Resonance Imaging in Multiple SclerosisNo drug interventionsotherNot Availablecompleted
NCT06274671
Glymphatic MRI in Clinically Isolated SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT06395909
A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT06455332
Predictive Value of the Optic Nerve Involvement in Clinically Isolated SyndromeNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT06526000
Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 TherapiesNo drug interventionsNot AvailableNot Availablecompleted
NCT05154370
China National Registry of Neuro-Inflammatory DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT03541226
Clinical Monitoring, MRI and Neuro-Ophthalmology of a Cohort of Patients With a Clinically Isolated Syndrome (CIS)No drug interventionsNot AvailableNot Availableunknown_status
NCT05706220
Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple SclerosisNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01737372
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT04998812
A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancyother4active_not_recruiting
NCT04705610
Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculographyNo drug interventionsotherNot Availablecompleted
NCT06280755
Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02043964
Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis CriterionNo drug interventionsdiagnosticNot Availablecompleted
NCT00287079
A Prospective Study Looking at the Use of Rebif® in Subjects With Clinically Isolated Syndrometreatment3completed
NCT03004079
Clinical Importance of Glucose Regulation in Relapsing MSNo drug interventionsNot AvailableNot Availableunknown_status
NCT04998851
A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumabother4recruiting
NCT04009005
Clinically Isolated Syndrome and Relapsing-Remitting Multiple SclerosisNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00819897
Longitudinal Study in Clinically Isolated Syndrome (CIS) Patients Treated With Interferon BetaNo drug interventionsNot AvailableNot Availableterminated
NCT00617383
AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MSNo drug interventionsNot AvailableNot Availablecompleted
NCT00232193
Safety/Effectiveness of Adding Monthly Dexamethasone to Weekly Avonex for MSNo drug interventionsNot AvailableNot Availablecompleted
NCT01371071
Cohort Study of Clinically Isolated Syndrome and Early Multiple SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT00813709
Long-term Follow-Up of Patients Who Participated in Study 27025 (REFLEX)treatment3completed
NCT04291456
Minocycline in MS: Confirmation of Benefittreatment3terminated
NCT05204459
MS-ResearchBiomarkerSNo drug interventionsNot AvailableNot Availablerecruiting
NCT03586986
Risk Factors in Early Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03610139
Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis PatientsNo drug interventionsotherNot Availableunknown_status
NCT01728922
Dose-related Effects of Vitamin D3 on Immune Responses in Patients With Clinically Isolated SyndromeNo drug interventionstreatment1 / 2completed
NCT03438357
Evaluation of an Automatic Segmentation Software (Pixyl.Neuro) to Track Lesions in Multiple Sclerosis Patients Via Cerebral MRINo drug interventionsNot AvailableNot Availablecompleted
NCT06541626
Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT00595920
Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple SclerosisNo drug interventionstreatment2terminated
NCT02671682
Immunoadsorption vs. Plasmapheresis in the Escalation Therapy of Relapse in Multiple SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT05057676
Autoimmune Intervention Mastery Course StudyNo drug interventionssupportive_careNot Availablerecruiting
NCT03979391
Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated SyndromeNo drug interventionsdiagnosticNot Availablerecruiting
NCT05277740
Implementation of a Novel Functional Eye-Tracking Biomarker for Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02254304
Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™treatment4completed
NCT04387110
Ocrelizumab in BreastmilkNot AvailableNot Availablecompleted
NCT03451955
The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CISNo drug interventionstreatmentNot Availablecompleted
NCT04466150
Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onsetbasic_science4active_not_recruiting
NCT04599023
Assessing the Feasibility of the MSPT Device in Routine Clinical Practice in the Swiss Healthcare SystemNo drug interventionsNot AvailableNot Availableterminated
NCT00666887
Minocycline in Clinically Isolated Syndromes (CIS)prevention3completed
NCT02308579
Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT01804647
Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04038541
Prebiotic vs Probiotic in Multiple SclerosisNo drug interventionsotherNot Availablecompleted
NCT05010902
Pregnancy Cohort in Multiple Sclerosis (MS)No drug interventionsNot AvailableNot Availablerecruiting
NCT02695394
Emotional Processing in Multiple Sclerosis / Clinically Isolated Syndrome: A Neuropsychological fMRI-studyNo drug interventionsNot AvailableNot Availablecompleted
NCT01414816
Betaferon® Regulatory Post-Marketing SurveillanceNot AvailableNot Availablecompleted