Nocturnal Enuresis (DBCOND0001411)

Identifiers

Synonyms

Bedwetting / Enuresis, Nocturnal / Bed Wetting / Nocturnal enuresis / Nocturnal enuresis (disorder) / Enuresis / Enuresis NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Potassium voltage-gated channel subfamily KQT member 2target Alpha-2A adrenergic receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Histamine H1 receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 1Atarget Alpha-1A adrenergic receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Potassium voltage-gated channel subfamily A member 1target Alpha-1D adrenergic receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget High affinity nerve growth factor receptortarget BDNF/NT-3 growth factors receptortarget Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Histamine H2 receptortarget Histamine H4 receptortarget Sigma non-opioid intracellular receptor 1target 5-hydroxytryptamine receptor 2Ctarget Alpha-1B adrenergic receptortarget 5-hydroxytryptamine receptor 7target 5-hydroxytryptamine receptor 1Dtarget Mu-type opioid receptortarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 6target Potassium voltage-gated channel subfamily KQT member 3target UDP-glucuronosyltransferase 2B10enzyme 5-hydroxytryptamine receptor 2Ctarget Muscarinic acetylcholine receptortarget HERG human cardiac K+ channeltarget ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A4enzyme Glutathione S-transferases (Cytosolic)enzyme
Trimipramine	A tricyclic antidepressant used to treat depression.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Cytochrome P450 2D6enzyme Sodium-dependent dopamine transportertarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 1Atarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget D(2) dopamine receptortarget Alpha-2B adrenergic receptortarget Histamine H1 receptortarget Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 1Dtarget Alpha-2A adrenergic receptortarget D(1) dopamine receptortarget Beta adrenergic receptortarget Muscarinic acetylcholine receptortarget 5-hydroxytryptamine receptor 2Ctarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06135311	Optimal Pulse Width Used in Transcutaneous Electrical Nerve Stimulation for Treating Nocturnal Enuresis in Children	No drug interventions	treatment	Not Available	recruiting
NCT02747849	Hand & Foot Nocturnal Enuresis TENS Study	No drug interventions	treatment	Not Available	completed
NCT05214131	Randomized Study Of Novel Enuresis Alarm vs Standard Bedwetting Alarm	No drug interventions	treatment	Not Available	recruiting
NCT02315560	Foot Neuromodulation for Nocturnal Enuresis	No drug interventions	treatment	Not Available	completed
NCT02747810	Pilot Study: Foot Neuromodulation for Nocturnal Enuresis in Children	No drug interventions	treatment	Not Available	withdrawn
NCT02900495	Transcutaneous Electric Nerve Stimulation (TENS) for the Treatment of Nocturnal Enuresis in Children	No drug interventions	treatment	Not Available	completed
NCT06185361	Selective Serotonin Reuptake Inhibitors, Fluoxetine Versus the Standard Oral Desmopressin for Management of Mono-symptomatic Nocturnal Enuresis.	Desmopressin Fluoxetine	treatment	Not Available	active_not_recruiting
NCT05126732	Ganglion Cell Thickness in Enuresis Nocturna	No drug interventions	Not Available	Not Available	unknown_status
NCT03522818	Enuresis Alarm - Is a Manual Trigger System Beneficial?	No drug interventions	treatment	Not Available	unknown_status
NCT06488976	Nocturnal Enuresis Symptom Score	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03543995	The Relationship Between Nocturnal Enuresis And Spina Bifida Occulta	No drug interventions	Not Available	Not Available	completed
NCT04280887	MyPad - Intelligent Bladder Pre-void Alerting System	No drug interventions	device_feasibility	Not Available	completed
NCT04413461	Comparative Study of the Efficacy of TENS Versus Placebo in Isolated Primary Enuresis	No drug interventions	other	Not Available	recruiting
NCT04260646	Alarm Treatment for Combined Enuresis and Daytime Urinary Incontinence in Children	No drug interventions	treatment	Not Available	completed
NCT03389412	The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.	Desmopressin	treatment	4	completed
NCT05151081	Overactive Bladder Syndrome	No drug interventions	Not Available	Not Available	completed
NCT02154152	A Clinical Study on Causticum 200 Centesimal Potency in Primary Enuresis	Potassium	treatment	3	unknown_status
NCT04313192	TENS Treatment for Bedwetting	No drug interventions	treatment	Not Available	recruiting
NCT06586476	The Role of Timed Awakening in Treatment of Enuresis	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT02538302	Minirin Versus Oxybutynin for Nocturnal Enuresis in Children	Desmopressin Oxybutynin	treatment	3	completed
NCT02636387	Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease	Desmopressin	Not Available	Not Available	terminated
NCT04620356	Effect of Use of DryNites Absorbent Pants on the Rate of Spontaneous Resolution of Paediatric Nocturnal Enuresis (NE)	No drug interventions	treatment	Not Available	unknown_status
NCT04420585	Desmopressin for Bedwetting in Children With SCD	Desmopressin	treatment	4	terminated
NCT03510975	A New Check-list Method for Nocturnal Enuresis	Desmopressin	treatment	4	completed
NCT01582542	Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction	Desmopressin	treatment	4	unknown_status
NCT05710718	PureWick™ France and U.S. At-Home Pilot Study	No drug interventions	treatment	Not Available	enrolling_by_invitation
NCT04049019	Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria	No drug interventions	diagnostic	Not Available	completed
NCT05178641	Overnight Pant Study for Children With Nocturnal Enuresis	No drug interventions	other	Not Available	completed
NCT03883724	Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production	No drug interventions	other	Not Available	completed
NCT04191863	Sleep Architecture in Valproate-induced Nocturnal Enuresis in Primary School and Preschool Children.	Valproic acid	Not Available	Not Available	completed
NCT02600676	Transcutaneous Electric Nerve Stimulation (TENS) in Children With Enuresis	No drug interventions	treatment	Not Available	completed
NCT02068560	The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion	Desmopressin	basic_science	Not Available	completed
NCT03477812	Sleep and Nocturnal Enuresis: Ambulatory Polysomnographic Study	No drug interventions	Not Available	Not Available	unknown_status
NCT05617664	Mirabegron 25 mg for Treatment of Primary Nocturnal Enuresis	Desmopressin Mirabegron	treatment	Not Available	recruiting
NCT00245479	A Study of Oral Desmopressin in Previously Untreated Children Aged 5 to 15 Years With Primary Nocturnal Enuresis	No drug interventions	treatment	4	completed
NCT01078753	Study With Two Different Doses of Desmopressin Orally Lyophilisate Tablet With Nocturnal Enuresis	Desmopressin	treatment	3	completed
NCT01575678	The Effect of Melatonin on Nocturnal Enuresis	Lactose Melatonin	treatment	2	unknown_status
NCT06243042	Vitamin D Serum Levels in Monosymptomatic Enuretic and Non Enuretic Children	No drug interventions	Not Available	Not Available	completed
NCT06285006	Desmopressin Monotherapy for Monosymptomatic Nocturnal Enuresis	Desmopressin	treatment	Not Available	recruiting
NCT02621736	Copeptin for Prediction of Treatment Response in Children With Monosymptomatic Nocturnal Enuresis (MEN).	No drug interventions	Not Available	Not Available	completed
NCT02337413	Urotherapy vs. Urotherapy With Constipation Treatment for Nocturnal Enuresis	Oxyphenisatin Polyethylene glycol	treatment	4	withdrawn
NCT01368913	MINRIN® Orally Disintegrating Tablet (Fast Dissolving Desmopressin) and Tablets in Treatment of Primary Nocturnal Enuresis	No drug interventions	Not Available	Not Available	completed
NCT04676139	The Safety and Efficacy of Fluoxetine for Refractory Primary Mono-symptomatic Nocturnal Enuresis in Children	Fluoxetine	treatment	3	unknown_status
NCT05306639	Treatment of Monosymptomatic Nocturnal Enuresis	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT02178826	Nocturnal Enuresis and Rapid Maxillary Expansion	No drug interventions	treatment	Not Available	completed
NCT03047720	Scheduled Awakenings for the Treatment of Nocturnal Enuresis	No drug interventions	treatment	Not Available	completed
NCT03812094	Basic Bladder Advice and Alarm Therapy in Nocturnal Enuresis	No drug interventions	treatment	Not Available	completed
NCT06231394	Effectiveness of Multimodal Pelvic Floor Rehabilitation Program in Children With Different Types of Urinary Incontinence	No drug interventions	treatment	Not Available	recruiting
NCT02328092	A Double-blind Randomized Clinical Trial on the Efficacy of Magnetic Sacral Roots Stimulation for the Treatment of NE	No drug interventions	treatment	Not Available	completed
NCT03199508	Clinical Values of Voiding Diary for Diagnosis and Treatment for Monosymptomatic Enuresis in Children	No drug interventions	diagnostic	Not Available	unknown_status