Cholestatic pruritus

Also known as: Cholestatic pruritis / Cholestatic pruritus (disorder)

Drug	Drug Name	Drug Description
DB16226	Maralixibat	An ileal bile acid transporter inhibitor indicated to treat cholestatic pruritus in patients with Alagille syndrome.
DB00704	Naltrexone	A narcotic antagonist used in opioid overdose.
DB16261	Odevixibat	An ileal sodium/bile acid cotransporter inhibitor indicated in the treatment of pruritus in patients with progressive familial intrahepatic cholestasis.
DB00904	Ondansetron	A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB01045	Rifampin	An antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.

Drug	Drug Name	Target	Type
DB16226	Maralixibat	Ileal sodium/bile acid cotransporter	target
DB16226	Maralixibat	Solute carrier organic anion transporter family member 2B1	transporter
DB16226	Maralixibat	Cytochrome P450 3A4	enzyme
DB16226	Maralixibat	Hepatic sodium/bile acid cotransporter	target
DB00704	Naltrexone	Mu-type opioid receptor	target
DB00704	Naltrexone	Kappa-type opioid receptor	target
DB00704	Naltrexone	Delta-type opioid receptor	target
DB00704	Naltrexone	UDP-glucuronosyltransferase 1A1	enzyme
DB00704	Naltrexone	Sigma non-opioid intracellular receptor 1	target
DB16261	Odevixibat	Ileal sodium/bile acid cotransporter	target
DB16261	Odevixibat	ATP-dependent translocase ABCB1	transporter
DB00904	Ondansetron	5-hydroxytryptamine receptor 3A	target
DB00904	Ondansetron	Cytochrome P450 3A4	enzyme
DB00904	Ondansetron	Cytochrome P450 1A2	enzyme
DB00904	Ondansetron	Cytochrome P450 2D6	enzyme
DB00904	Ondansetron	Cytochrome P450 3A5	enzyme
DB00904	Ondansetron	Cytochrome P450 3A7	enzyme
DB00904	Ondansetron	5-hydroxytryptamine receptor 4	target
DB00904	Ondansetron	5-hydroxytryptamine receptor 1A	target
DB00904	Ondansetron	5-hydroxytryptamine receptor 1B	target
DB00904	Ondansetron	Mu-type opioid receptor	target
DB00904	Ondansetron	Cytochrome P450 2C9	enzyme
DB00904	Ondansetron	Cytochrome P450 2E1	enzyme
DB01045	Rifampin	Nuclear receptor subfamily 1 group I member 2	target
DB01045	Rifampin	Cytochrome P450 3A4	enzyme
DB01045	Rifampin	Cytochrome P450 1A2	enzyme
DB01045	Rifampin	Cytochrome P450 2C8	enzyme
DB01045	Rifampin	UDP-glucuronosyltransferase 1A1	enzyme
DB01045	Rifampin	Cytochrome P450 2C9	enzyme
DB01045	Rifampin	Cytochrome P450 2B6	enzyme
DB01045	Rifampin	Cytochrome P450 2C19	enzyme
DB01045	Rifampin	ATP-binding cassette sub-family C member 3	transporter
DB01045	Rifampin	ATP-binding cassette sub-family C member 5	transporter
DB01045	Rifampin	ATP-dependent translocase ABCB1	transporter
DB01045	Rifampin	ATP-binding cassette sub-family C member 2	transporter
DB01045	Rifampin	Solute carrier organic anion transporter family member 2B1	transporter
DB01045	Rifampin	Bile salt export pump	transporter
DB01045	Rifampin	Multidrug resistance-associated protein 1	transporter
DB01045	Rifampin	Solute carrier organic anion transporter family member 1A2	transporter
DB01045	Rifampin	Solute carrier organic anion transporter family member 1B3	transporter
DB01045	Rifampin	Solute carrier family 22 member 7	transporter
DB01045	Rifampin	Solute carrier organic anion transporter family member 1B1	transporter
DB01045	Rifampin	Cytochrome P450 2A6	enzyme
DB01045	Rifampin	Cytochrome P450 2E1	enzyme
DB01045	Rifampin	Cytochrome P450 3A43	enzyme
DB01045	Rifampin	Cytochrome P450 3A7	enzyme
DB01045	Rifampin	Solute carrier family 22 member 6	transporter
DB01045	Rifampin	Organic anion transporter 3	transporter
DB01045	Rifampin	UDP-glucuronosyltransferase 1A9	enzyme
DB01045	Rifampin	Cytochrome P450 3A5	enzyme
DB01045	Rifampin	Albumin	carrier
DB01045	Rifampin	alpha1-acid glycoprotein	carrier
DB01045	Rifampin	DNA-directed RNA polymerase subunit beta	target

Drug	Drug Name	Phase	Status	Count
DB11938	Difelikefalin	2	Terminated	1