Parkinsonism

Also known as: Parkinsonism, unspecified / Parkinsonian Disorders / Parkinsonism (disorder) / Hypokinetic-rigid syndrome / Secondary parkinsonism, unspecified / Symptomatic parkinsonism (disorder) / Secondary parkinsonism (disorder) / Parkinson Disease, Secondary / Secondary parkinsonism

DrugDrug NameDrug Description
DB00915AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
DB00572AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB00245BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
DB00424HyoscyamineAn anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis.
DB01235LevodopaA dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
DB00387ProcyclidineAn antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms.
DB00392ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
DrugDrug NameTargetType
DB00915AmantadineDopamine D2 receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00572AtropineAlpha-1-acid glycoprotein 1carrier
DB00245BenzatropineMuscarinic acetylcholine receptor M1target
DB00245BenzatropineSodium-dependent dopamine transportertarget
DB00245BenzatropineHistamine H1 receptortarget
DB00245BenzatropineSerum albumincarrier
DB00245BenzatropineSodium-dependent serotonin transportertarget
DB00245BenzatropineSodium-dependent noradrenaline transportertarget
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00424HyoscyamineAdenylate cyclase type 1target
DB01235LevodopaDopamine D1 receptortarget
DB01235LevodopaDopamine D2 receptortarget
DB01235LevodopaAromatic-L-amino-acid decarboxylaseenzyme
DB01235LevodopaSolute carrier family 15 member 1transporter
DB01235LevodopaMonocarboxylate transporter 10transporter
DB01235LevodopaDopamine D3 receptortarget
DB01235LevodopaDopamine D4 receptortarget
DB01235LevodopaDopamine D5 receptortarget
DB01235LevodopaLarge neutral amino acids transporter small subunit 1transporter
DB01235LevodopaLarge neutral amino acids transporter small subunit 2transporter
DB01235LevodopaSerum albumincarrier
DB00387ProcyclidineMuscarinic acetylcholine receptor M1target
DB00387ProcyclidineMuscarinic acetylcholine receptor M2target
DB00387ProcyclidineMuscarinic acetylcholine receptor M4target
DB00387ProcyclidineMuscarinic acetylcholine receptor M3target
DB00392ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
DB00392ProfenamineMuscarinic acetylcholine receptor M1target
DB00392ProfenamineCholinesteraseenzyme
DB00392ProfenamineMuscarinic acetylcholine receptor M2target
DrugDrug NamePhaseStatusCount
DB19222THK-53512Completed1
DB19223THK-5351 F-182Completed1
DB00915Amantadine4Completed1
DB06262Droxidopa4Terminated1
DB09420Iodide I-1234Enrolling by Invitation1
DB08824Ioflupane I-1234Enrolling by Invitation1
DB01273Varenicline4Unknown Status1
DB00399Zoledronic acid4Recruiting1
DB00909Zonisamide4Suspended1
DB00980RamelteonNot AvailableTerminated1