Carcinoma of the Head and Neck (DBCOND0030102)

Identifiers

Synonyms
Carcinoma of Head and Neck / Head and Neck Carcinoma / Head-and-neck Carcinoma

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Gemcitabine
A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
Mitomycin
An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
Uracil
An antineoplastic agent used in combination with tegafur to treat various cancers, including breast, prostate, and liver cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00865098
Study of Cetuximab With Concomitant-boost Radiotherapy in Patients With Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)treatment2completed
NCT00184028
Combination of Taxotere and Oxaliplatin in Squamous Cell Carcinoma of the Head and Necktreatment2terminated
NCT02626000
Talimogene Laherparepvec With Pembrolizumab for Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY232 / KEYNOTE-137)treatment1completed
NCT00257335
Intensity-Modulated Radiotherapy for Recurrent Head and Neck CancerNo drug interventionstreatment2withdrawn
NCT05461430
Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)No drug interventionsNot AvailableNot Availablerecruiting
NCT04985357
Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to DrugsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01007240
Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine NanoparticlesNo drug interventionsprevention1unknown_status
NCT00050388
Phase II Trial of Allovectin-7® for Head and Neck CancerNo drug interventionstreatment3completed
NCT03001570
Accelerated Modulated Fractionation (SIB-IMRT) for Head and Neck Districttreatment2recruiting
NCT03733210
Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancerdiagnostic1completed
NCT05012397
Milademetan in Advanced/Metastatic Solid Tumorstreatment2terminated
NCT05077072
Interdisciplinary Interventions to Address Pain Management Among Head and Neck Cancer PatientsNo drug interventionssupportive_care2recruiting
NCT02465060
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)screening2active_not_recruiting
NCT06572423
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)No drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT02543320
Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients with Head and Neck CancerNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT06627270
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancertreatment2not_yet_recruiting
NCT04870762
Customized 3D Printed Oral Stents During Head and Neck RadiotherapyNo drug interventionstreatment2recruiting
NCT05075980
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Studytreatment2recruiting
NCT05224271
Evaluating Patient Reported Outcomes in Radiation Therapy, the PRO-RT StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05544136
A Study of Decreasing Radiation Therapy and Chemotherapy in People with Head and Neck Cancertreatment2recruiting
NCT06079697
An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing Head and Neck Cancer SurgeryNo drug interventionssupportive_careNot Availablerecruiting
NCT01384890
Feasibility of VMAT and CBCT for Head and Neck CarcinomasNo drug interventionstreatment1completed
NCT03602079
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 GeneNo drug interventionstreatment1 / 2completed
NCT03888651
Clinical Data Collection in Studying Clinical Factors Associated With Post-Surgery Chronic Opioid Use in Patients With Head and Neck CancersNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03993353
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancertreatment2recruiting
NCT03268993
Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and Neck CancerNo drug interventionsbasic_scienceNot Availablecompleted
NCT04618432
Collection of Clinical Data and Specimens for Research on Head and Neck and Communication DisordersNo drug interventionsNot AvailableNot Availableterminated
NCT06289049
Heavy Strength Training in Head and Neck Cancer SurvivorsNo drug interventionsother2not_yet_recruiting
NCT04110249
Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck CancerNo drug interventionsdiagnosticNot Availableterminated
NCT06420219
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and RecurrenceNo drug interventionsNot AvailableNot Availablerecruiting
NCT05650034
Post-Operative Radiotherapy De-Escalation of Negative Nodal Regions in Head and Neck Squamous Cell CarcinomaNo drug interventionstreatmentNot Availableunknown_status
NCT03964896
Nurse-Driven Telephone Intervention in Improving Side Effects in Cancer Patients Undergoing ChemotherapyNo drug interventionssupportive_careNot Availablecompleted
NCT02369835
Modified Dakin's Solution in Reducing Radiation-Induced Dermatitis in Patients With Head and Neck Cancer Undergoing Radiation Therapysupportive_care3completed
NCT05115825
Pain Management for Head and Neck Cancer SurvivorsNo drug interventionssupportive_careNot Availablerecruiting
NCT03602066
Study Evaluating The Role of ClO2 on Mucositis for Pt. Undergoing Head/Neck Radiotherapysupportive_care2terminated
NCT01228565
Trial of OTD70DERM® in Radio-dermatitis Induced by Radiotherapy-Erbitux®No drug interventionsprevention3completed
NCT03135782
Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation TherapyNo drug interventionshealth_services_researchNot Availablecompleted
NCT03612531
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer SurvivorsNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03370276
Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinomatreatment1 / 2active_not_recruiting
NCT03261180
Nestle Impact Advanced Recovery in Improving Surgery Recovery in Patients With Head and Neck CancerNo drug interventionssupportive_careNot Availablewithdrawn
NCT06007092
Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal CancerNo drug interventionstreatment1 / 2recruiting
NCT06248944
AIOCC Italian Registry on Head and Neck CarcinomasNo drug interventionsNot AvailableNot Availablerecruiting
NCT05828004
Effect of Whole-Course Multidisciplinary Care Intervention on Patients With Head and Neck CarcinomaNo drug interventionspreventionNot Availablecompleted
NCT05073172
StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Patientssupportive_careNot Availablewithdrawn
NCT04655469
Personal Health Train for Radiation Oncology in India and The NetherlandsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06494046
Defining Musical Toxicity and Its Effect on Patient Well-beingNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03795610
Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinomatreatment2recruiting
NCT02474095
Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck CancerNo drug interventionssupportive_careNot Availablecompleted
NCT05018208
Remote Monitoring in Cancer Care: A Platform StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03154190
Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With CancerNo drug interventionshealth_services_researchNot Availableunknown_status
NCT03745690
Near-Infrared Image Guided Surgical Resection With Indocyanine Green in Treating Patients With Head and Neck Cancertreatment1 / 2withdrawn
NCT04788264
Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer TreatmentNo drug interventionssupportive_careNot Availablecompleted
NCT01973179
Re-irradiation of Recurrent Head and Neck CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT02586987
A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumourstreatment1completed
NCT04666428
Effects of Human Papillomavirus Diagnosis on Relationships of Patients With Head and Neck CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT03556228
Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphomatreatment1recruiting
NCT01627093
Medical Data Collection of Patients With Head and Neck Cancer Treated With Proton TherapyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03663985
FALCOn (Facteur AnthropoLogique Cancer Orl)No drug interventionsNot AvailableNot Availablecompleted
NCT03489252
Remote Activity Monitored by Fitbit Charge 3 in Investigating Daily Step and Sleep Data in Participants With Head and Neck Cancer Undergoing Radiation TherapyNo drug interventionssupportive_careNot Availablecompleted
NCT02615275
Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Cancer Undergoing Radiation TherapyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05565313
Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AINo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04890834
Dyadic Yoga Intervention for the Improvement of Healthcare Utilization and Quality of Life in Patients With Head and Neck Cancer Undergoing Chemoradiation and Their CaregiversNo drug interventionssupportive_careNot Availablerecruiting
NCT05526924
Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancertreatment1recruiting
NCT04814524
A Digital Intervention Protocol to Enhance Recovery After Head and Neck SurgeryNo drug interventionssupportive_careNot Availablecompleted
NCT03902535
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their CaregiversNo drug interventionsNot AvailableNot Availablecompleted
NCT03524326
Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinomatreatment1completed
NCT03591666
A Study of Anlotinib in Recurrent/Metastatic Head and Neck Adenocarcinomastreatment2unknown_status
NCT02718820
Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancertreatment1 / 2completed
NCT04151082
High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivorssupportive_care1 / 2recruiting
NCT02555176
Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC)No drug interventionsbasic_scienceNot Availablecompleted
NCT04147494
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer TissuesNo drug interventionsbasic_science0recruiting
NCT00991094
Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01831089
Phase I Study of Lurbinectedin (PM01183) in Combination With Paclitaxel, With or Without Bevacizumab, in Selected Advanced Solid Tumorstreatment1completed
NCT04475640
Cancer Genetic Testing in Ethnic PopulationsNo drug interventionsscreeningNot Availablerecruiting
NCT01507467
IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell Carcinoma of the Head and NeckNo drug interventionstreatment3terminated
NCT05512767
A Pneumatic Compression Device for the Treatment of Lymphedema in Patients With Stage II-IV Head and Neck Cancer After ChemoradiationNo drug interventionstreatmentNot Availablewithdrawn
NCT06183268
Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton TherapyNo drug interventionssupportive_careNot Availablerecruiting
NCT02649569
Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastrointestinal CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05334069
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03340038
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free FlapsNo drug interventionshealth_services_researchNot Availablecompleted