First Line Chemotherapy (DBCOND0042658)

Identifiers

Synonyms

First-line chemotherapy

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amivantamab	An EGF and MET receptor targeted antibody indicated in the treatment of non-small cell lung cancer with an EGFR 20 exon insertion mutation.	Epidermal growth factor receptortarget Hepatocyte growth factor receptortarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget
Avelumab	An anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.	Programmed cell death 1 ligand 1target
Axitinib	An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.	Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Tyrosine-protein kinase ABL1target
Bevacizumab	A monoclonal anti-vascular endothelial growth factor antibody used in combination with antineoplastic agents for the treatment of many types of cancer.	Vascular endothelial growth factor A, long formtarget Complement C1q subcomponent subunit Atarget Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget High affinity immunoglobulin gamma Fc receptor Itarget
Cemiplimab	A programmed death receptor-1 blocking antibody used to treat cutaneous squamous cell carcinoma, basal cell carcinoma, and non-small cell lung cancer.	Programmed cell death protein 1target
Durvalumab	An antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.	Programmed cell death 1 ligand 1target Programmed cell death protein 1target
Hyaluronidase (ovine)	A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.	Transforming growth factor beta-1 proproteintarget Albumincarrier Hyaluronantarget
Ipilimumab	A human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.	Cytotoxic T-lymphocyte protein 4target
Irinotecan	A topoisomerase inhibitor used to treat metastatic carcinoma of the colon or rectum and pancreatic adenocarcinoma.	DNA topoisomerase I, mitochondrialtarget DNA topoisomerase 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 1B1transporter Multidrug resistance-associated protein 1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Human Carboxylesterasesenzyme
Lazertinib	A tyrosine kinase inhibitor used in combiantion with amivantamab to treat non-small cell lung cancer with EGFR mutations.	Cytochrome P450 3A4enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A1enzyme Glutathione S-transferase Mu 1enzyme Solute carrier family 22 member 1transporter Epidermal growth factor receptortarget
Osimertinib	A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.	Epidermal growth factor receptortarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme
Rituximab	A monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis.	B-lymphocyte antigen CD20target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05729737	Radiographic Response to Chemotherapy in Unresected Localized Pancreatic Cancer	No drug interventions	Not Available	Not Available	recruiting
NCT00816634	Efficacy Comparison Study of Combination Regimens to Treat Advanced Esophageal Squamous Cell Carcinoma	Capecitabine Cisplatin Paclitaxel	treatment	2	unknown_status