Leiomyosarcoma (LMS) (DBCOND0118909)

Identifiers

Synonyms
LMS - Leiomyosarcoma / Leiomyosarcomas / Leiomyosarcoma / Leiomyosarcoma (morphologic abnormality) / Leiomyosarcoma NOS / Leiomyosarcoma (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Sorafenib
A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02822495
Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or MalignanciesNot AvailableNot Availableno_longer_available
NCT04727242
CytoreductiveSurgery & HIPEC W/Gemcitabine+Chemotherapy W/Dacarbazine in Uterine Leiomyosarcomatreatment2recruiting
NCT05227326
AOH1996 for the Treatment of Refractory Solid TumorsNo drug interventionstreatment1recruiting
NCT05080790
Treatment with Dinutuximab Beta, Zoledronic Acid and Low-dose Interleukin (IL-2) in Patients with Leiomyosarcomatreatment2active_not_recruiting
NCT06498648
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcomatreatment1 / 2not_yet_recruiting
NCT06638931
Agnostic Therapy in Rare Solid TumorsNo drug interventionstreatment2recruiting
NCT02180867
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgerytreatment2 / 3active_not_recruiting
NCT06088290
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcomatreatment2 / 3recruiting
NCT06299163
NM32-2668 in Adult Patients With Selected Advanced Solid TumorsNo drug interventionstreatment1recruiting
NCT02249702
Activity of Trabectedin or Gemcitabine + Docetaxel in Uterine Leiomyosarcomatreatment2completed
NCT01956084
Cytotoxic T Cells to Treat Relapsed EBV-positive LymphomaNo drug interventionstreatment1active_not_recruiting
NCT03526679
Lenvatinib and Eribulin in Advanced Soft Tissue Sarcomatreatment1 / 2unknown_status
NCT05548179
Exploring Clinical Trial Experiences of People With LeiomyosarcomaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06277154
MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcomatreatment2not_yet_recruiting
NCT04031677
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal SarcomaNo drug interventionstreatment3recruiting
NCT03241745
A Study of Nivolumab in Selected Uterine Cancer Patientstreatment2completed
NCT00815945
Multicenter Trial With PegLiposomal Doxorubicin and Carboplatin Combination Chemotherapy in Gynecological Sarcomas and Mixed Epithelial-Mesenchymal Tumorstreatment2completed
NCT03899805
A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomastreatment2active_not_recruiting
NCT06526897
Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue SarcomaNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT05116683
ATX-101 in Advanced Dedifferentiated Liposarcoma and Leiomyosarcomatreatment2terminated
NCT05427461
Circulating " Cancer Cells / Macrophage " HYbrid Cells in Patients With Sarcoma, Part 2No drug interventionsotherNot Availablerecruiting
NCT05653388
Metastatic Leiomyosarcoma Biomarker ProtocolNo drug interventionsNot AvailableNot Availablerecruiting
NCT02584309
Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcomatreatment2completed
NCT05204524
Temozolomide for Injection Combined With Epirubicin in First-line Treatment of LeiomyosarcomatreatmentNot Availableunknown_status
NCT03989596
Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue SarcomasNo drug interventionstreatment2unknown_status
NCT02983539
Detection of Circulating Tumor Cells in Patients With SarcomasNo drug interventionsNot AvailableNot Availableunknown_status
NCT00837148
Sorafenib and Dacarbazine in Soft Tissue Sarcomatreatment2completed
NCT00668148
A Five-Tier, Open-Label Study of IMC-A12 in Advanced Sarcomatreatment2completed
NCT04214457
Development of a Predictive Model for Early Differential Diagnosis of Uterine Leiomyomas and LeiomyosarcomasNo drug interventionsNot AvailableNot Availableunknown_status
NCT04055220
Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone SarcomastreatmentNot Availablerecruiting
NCT06521060
The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial LesionsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00093080
Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)treatment2completed
NCT02247544
Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcomatreatment2completed
NCT01418001
Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS)treatment1 / 2terminated
NCT05094804
A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agentstreatment1 / 2recruiting
NCT00062868
LMP-specific T-cells for Patients With Relapsed EBV-positive LymphomaNo drug interventionstreatment1completed
NCT00400569
Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcomatreatment2completed
NCT06528769
A Phase II Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcomatreatment2not_yet_recruiting
NCT03761095
A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)treatment1completed
NCT00503295
Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lungtreatment2completed
NCT03420014
Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)treatment2recruiting
NCT05269355
A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)treatment2 / 3active_not_recruiting
NCT00856050
Letrozole in Women With Advanced Estrogen/Progesterone Receptor Positive Uterine Leiomyosarcomatreatment2completed
NCT04242238
Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomastreatment1active_not_recruiting
NCT00282087
Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcomatreatment2completed
NCT01426633
Combination Therapy of Gemcitabine and Trabectedin in L-sarcomastreatment1completed
NCT03959033
Patient Reported Outcome Measures (PROMs) With TrabectedinNo drug interventionsNot AvailableNot Availableterminated
NCT04099277
A Study of LY3435151 in Participants With Solid Tumorstreatment1terminated
NCT04535271
Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Leiomyosarcomatreatment2recruiting
NCT04624178
A Study of Rucaparib and Nivolumab in People With Leiomyosarcomatreatment2active_not_recruiting
NCT02923778
Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgerytreatment2active_not_recruiting
NCT03509207
Vorinostat (SAHA) in Uterine Sarcomatreatment2terminated
NCT00887809
Gemcitabine and Docetaxel With Bevacizumab in Selected Sarcoma Subtypestreatment2completed
NCT01447056
Most Closely HLA-Matched CTLs for Relapsed Epstein Barr Virus(EBV)-Associated DiseasesNo drug interventionstreatment1completed
NCT05116800
Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcomatreatment2withdrawn
NCT04420975
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcomatreatment1active_not_recruiting
NCT03651375
Hypofractionated Radiotherapy With Sequential Chemotherapy in Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk WallNo drug interventionstreatment2unknown_status
NCT03437070
Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent Leiomyosarcomatreatment1withdrawn
NCT06308419
A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletionstreatment1recruiting
NCT03016819
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)treatment3active_not_recruiting
NCT02940041
Concordance Between Sonography Amd MRI for Presurgical Diagnosis of Uterine Mesenchymal Malignant TumorsNo drug interventionsNot AvailableNot Availableterminated
NCT04811196
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patientstreatment1active_not_recruiting
NCT02275286
Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patientstreatment1 / 2recruiting
NCT00356031
Bevacizumab and Radiation Therapy for Sarcomastreatment2completed
NCT04906876
A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomastreatment2withdrawn
NCT00414076
Letrozole Versus Observation in Patients With Newly Diagnosed Uterine Leiomyosarcomatreatment2terminated
NCT03718091
M6620 (VX-970) in Selected Solid Tumorstreatment2completed
NCT01442662
Efficacy of Gemcitabine With Pazopanib as Second Line Treatment in Patient With Metastatic or Relapsed Uterinetreatment2completed
NCT04925089
Localized Leiomyosarcoma Biomarker ProtocolNo drug interventionsNot AvailableNot Availablerecruiting
NCT00060944
A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancertreatment2completed
NCT04996004
A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcomatreatment2terminated
NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordNo drug interventionsNot AvailableNot Availablerecruiting
NCT03773510
Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedintreatment3withdrawn
NCT03851614
Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumorstreatment2active_not_recruiting
NCT04554914
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseasestreatment2recruiting