Chordomas (DBCOND0042698)

Identifiers

Synonyms
Chordoma / Chordoma (disorder) / Chordoma (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Imatinib
A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Sirolimus
An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02834013
Nivolumab and Ipilimumab in Treating Patients With Rare Tumorstreatment2active_not_recruiting
NCT06625190
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumorstreatment1 / 2not_yet_recruiting
NCT05033288
Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the BoneNo drug interventionsNot AvailableNot Availablerecruiting
NCT05407441
Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumorstreatment1 / 2recruiting
NCT06029218
Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton TherapyNo drug interventionstreatmentNot Availablerecruiting
NCT04087902
Long-Term Longitudinal QoL in Patients Undergoing EEANo drug interventionsNot AvailableNot Availablerecruiting
NCT01182779
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull BaseNo drug interventionstreatment3unknown_status
NCT05861245
Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull BaseNo drug interventionstreatmentNot Availablerecruiting
NCT01407198
Nilotinib With Radiation for High Risk Chordomatreatment1active_not_recruiting
NCT02520128
A Study of IMRT in Primary Bone and Soft Tissue SarcomaNo drug interventionstreatmentNot Availablecompleted
NCT04246671
TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing CancerNo drug interventionstreatment1active_not_recruiting
NCT03083678
Afatinib in Locally Advanced and Metastatic Chordomatreatment2unknown_status
NCT00713037
Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With ChordomasNo drug interventionsdiagnosticNot Availablecompleted
NCT00410670
Chordoma Family StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02986516
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT03910465
Children and Adults With ChordomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00464620
Trial of Dasatinib in Advanced Sarcomastreatment2completed
NCT04486820
Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis CareNo drug interventionsNot AvailableNot Availablecompleted
NCT03242382
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression.treatment2recruiting
NCT05041127
Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordomatreatment2recruiting
NCT00150072
Efficacy and Safety of Imatinib in Chordomatreatment2completed
NCT03623854
Nivolumab and Relatlimab in Treating Participants With Advanced Chordomatreatment2completed
NCT02383498
QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordomatreatment2completed
NCT06535997
Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILENo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04042597
Anlotinib Hydrochloride Versus Imatinib Mesylate in Locally Advanced, Unresectable or Metastatic Chordomatreatment2unknown_status
NCT03595228
BN Brachyury and Radiation in ChordomaNo drug interventionstreatment2completed
NCT01347307
Stereotactic Body Radiotherapy for Spine TumorsNo drug interventionstreatmentNot Availablecompleted
NCT01175109
Study of Imatinib, a Platelet-derived Growth Factor Receptor Inhibitor, and LBH589, a Histone Deacetylase Inhibitor, in the Treatment of Newly Diagnosed and Recurrent Chordomatreatment1unknown_status
NCT06140732
Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordomatreatment2recruiting
NCT03955042
Pemetrexed for the Treatment of Chordomatreatment1completed
NCT02989636
Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordomatreatment1active_not_recruiting
NCT00496119
Proton Beam Therapy for Chordoma PatientsNo drug interventionstreatment2active_not_recruiting
NCT00349024
Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancersupportive_careNot Availableunknown_status
NCT00592748
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical SpineNo drug interventionstreatment1 / 2completed
NCT00003926
Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumorssupportive_care1terminated
NCT03190174
Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancerstreatment1 / 2completed
NCT04832620
Image Assisted Optimization of Proton Radiation Therapy in Chordomas and ChondrosarcomasNo drug interventionsNot AvailableNot Availablerecruiting
NCT00341627
Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma FamiliesNo drug interventionsNot AvailableNot Availablecompleted
NCT03110744
CDK4/6 Inhibition in Locally Advanced/Metastatic Chordomatreatment2completed
NCT00919269
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue SarcomaNo drug interventionsNot AvailableNot Availablecompleted
NCT01567046
Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue SarcomasNo drug interventionsNot AvailableNot Availablecompleted
NCT04091295
BLESSED: Expanded Access for DeltaRex-G for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of BreastNot AvailableNot Availableavailable
NCT03647423
QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma.treatment1 / 2withdrawn
NCT00797602
Proton Therapy for Chordomas and/or ChondrosarcomasNo drug interventionsNot AvailableNot Availablecompleted
NCT01449149
Proton Radiation for Chordomas and ChondrosarcomasNo drug interventionstreatmentNot Availableactive_not_recruiting