Diabetic Macular Edema (DME)

Also known as: Diabetic Macular Edema(DME) / Diabetic Macular Oedema / Macular Edema, Diabetic / Diabetic Macular Edema / Macular edema due to diabetes mellitus (disorder) / Diabetic retinal oedema / Diabetic retinal edema

Drug	Drug Name	Drug Description
DB08885	Aflibercept	A vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy.
DB01234	Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DB15303	Faricimab	An IgG1-derived bispecific antibody against VEGF-A and Ang-2 for the treatment of age-related macular degeneration and diabetic macular edema.
DB00591	Fluocinolone acetonide	A corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.
DB01270	Ranibizumab	A recombinant humanized monoclonal antibody and VEGF-A antagonist used for the management of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Drug	Drug Name	Target	Type
DB08885	Aflibercept	Vascular endothelial growth factor A	target
DB08885	Aflibercept	Placenta growth factor	target
DB08885	Aflibercept	Vascular endothelial growth factor B	target
DB01234	Dexamethasone	Glucocorticoid receptor	target
DB01234	Dexamethasone	Annexin A1	target
DB01234	Dexamethasone	Nitric oxide synthase, inducible	target
DB01234	Dexamethasone	Nuclear receptor subfamily 0 group B member 1	target
DB01234	Dexamethasone	Cytochrome P450 3A4	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A5	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A7	enzyme
DB01234	Dexamethasone	Bile salt export pump	transporter
DB01234	Dexamethasone	P-glycoprotein 1	transporter
DB01234	Dexamethasone	Canalicular multispecific organic anion transporter 1	transporter
DB01234	Dexamethasone	Solute carrier organic anion transporter family member 1A2	transporter
DB01234	Dexamethasone	ATP-binding cassette sub-family G member 2	transporter
DB01234	Dexamethasone	Steroid 17-alpha-hydroxylase/17,20 lyase	enzyme
DB01234	Dexamethasone	Cytochrome P450 1A1	enzyme
DB01234	Dexamethasone	Cytochrome P450 2A6	enzyme
DB01234	Dexamethasone	Cytochrome P450 2B6	enzyme
DB01234	Dexamethasone	Cytochrome P450 2C19	enzyme
DB01234	Dexamethasone	Cytochrome P450 2C8	enzyme
DB01234	Dexamethasone	Cytochrome P450 2E1	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A43	enzyme
DB01234	Dexamethasone	Cytochrome P450 4A11	enzyme
DB01234	Dexamethasone	Nuclear receptor subfamily 1 group I member 2	target
DB01234	Dexamethasone	Cytochrome P450 11B1, mitochondrial	enzyme
DB01234	Dexamethasone	Serum albumin	carrier
DB01234	Dexamethasone	Corticosteroid 11-beta-dehydrogenase isozyme 2	enzyme
DB01234	Dexamethasone	Corticosteroid 11-beta-dehydrogenase isozyme 1	enzyme
DB01234	Dexamethasone	Solute carrier family 22 member 8	transporter
DB15303	Faricimab	Vascular endothelial growth factor A	target
DB15303	Faricimab	Angiopoietin-2	target
DB00591	Fluocinolone acetonide	Corticosteroid-binding globulin	carrier
DB00591	Fluocinolone acetonide	Glucocorticoid receptor	target
DB00591	Fluocinolone acetonide	Cytochrome P450 3A4	enzyme
DB00591	Fluocinolone acetonide	Annexin A1	target
DB00591	Fluocinolone acetonide	Annexin A2	target
DB00591	Fluocinolone acetonide	Annexin A3	target
DB00591	Fluocinolone acetonide	Annexin A4	target
DB00591	Fluocinolone acetonide	Annexin A5	target
DB00591	Fluocinolone acetonide	Phospholipase A2	target
DB01270	Ranibizumab	Vascular endothelial growth factor A	target

Drug	Drug Name	Phase	Status	Count
DB08885	Aflibercept	1	Completed	2
DB00963	Bromfenac	1	Unknown Status	1
DB00095	Efalizumab	1	Withdrawn	1
DB11611	Lifitegrast	1	Terminated	1
DB15330	Nesvacumab	1	Completed	1
DB01270	Ranibizumab	1	Completed	1
DB01270	Ranibizumab	1	Withdrawn	2
DB00877	Sirolimus	1	Completed	1
DB06343	Teprotumumab	1	Completed	1
DB00620	Triamcinolone	1	Completed	2
DB00620	Triamcinolone	1	Unknown Status	1
DB08885	Aflibercept	1 / 2	Completed	3
DB00112	Bevacizumab	1 / 2	Completed	1
DB01200	Bromocriptine	1 / 2	Withdrawn	1
DB01234	Dexamethasone	1 / 2	Completed	1
DB00514	Dextromethorphan	1 / 2	Completed	1
DB11981	Elamipretide	1 / 2	Completed	1
DB00065	Infliximab	1 / 2	Unknown Status	1
DB00264	Metoprolol	1 / 2	Withdrawn	1
DB01017	Minocycline	1 / 2	Completed	1
DB01270	Ranibizumab	1 / 2	Completed	6
DB01270	Ranibizumab	1 / 2	Unknown Status	2
DB16353	Razuprotafib	1 / 2	Completed	1
DB14911	Risuteganib	1 / 2	Withdrawn	1
DB00706	Tamsulosin	1 / 2	Withdrawn	1
DB00620	Triamcinolone	1 / 2	Completed	1
DB00620	Triamcinolone	1 / 2	Unknown Status	1
DB08885	Aflibercept	2	Active Not Recruiting	1
DB08885	Aflibercept	2	Completed	4
DB08885	Aflibercept	2	Recruiting	1
DB08885	Aflibercept	2	Terminated	1
DB08885	Aflibercept	2	Withdrawn	3
DB09026	Aliskiren	2	Terminated	1
DB00112	Bevacizumab	2	Completed	6
DB06642	Bevasiranib	2	Completed	1
DB12460	Conbercept	2	Recruiting	1
DB01406	Danazol	2	Completed	2
DB01234	Dexamethasone	2	Completed	9
DB01234	Dexamethasone	2	Not Yet Recruiting	1
DB01234	Dexamethasone	2	Recruiting	1
DB01234	Dexamethasone	2	Withdrawn	1
DB00988	Dopamine	2	Recruiting	1
DB00869	Dorzolamide	2	Completed	1
DB15303	Faricimab	2	Completed	2
DB13873	Fenofibric acid	2	Completed	1
DB00591	Fluocinolone acetonide	2	Completed	1
DB00741	Hydrocortisone	2	Completed	1
DB16817	Ixoberogene soroparvovec	2	Active Not Recruiting	1
DB04465	Lactose	2	Recruiting	1
DB16021	Levosulpiride	2	Recruiting	1
DB00678	Losartan	2	Completed	1
DB00657	Mecamylamine	2	Completed	1
DB06802	Nepafenac	2	Completed	1
DB15330	Nesvacumab	2	Completed	1
DB05028	Ocriplasmin	2	Completed	1
DB08888	Ocriplasmin	2	Completed	1
DB14955	PF-04634817	2	Terminated	1
DB04895	Pegaptanib	2	Completed	1
DB01270	Ranibizumab	2	Completed	17
DB01270	Ranibizumab	2	Recruiting	3
DB01270	Ranibizumab	2	Terminated	2
DB01270	Ranibizumab	2	Withdrawn	2
DB16353	Razuprotafib	2	Completed	1
DB14911	Risuteganib	2	Completed	1
DB00877	Sirolimus	2	Completed	1
DB01268	Sunitinib	2	Completed	1
DB00373	Timolol	2	Completed	1
DB06273	Tocilizumab	2	Withdrawn	1
DB00620	Triamcinolone	2	Completed	6
DB00620	Triamcinolone	2	Recruiting	1
DB05268	iCo-007	2	Terminated	1
DB08885	Aflibercept	2 / 3	Active Not Recruiting	1
DB08885	Aflibercept	2 / 3	Completed	2
DB08885	Aflibercept	2 / 3	Unknown Status	1
DB00443	Betamethasone	2 / 3	Completed	1
DB00112	Bevacizumab	2 / 3	Active Not Recruiting	2
DB00112	Bevacizumab	2 / 3	Completed	1
DB00112	Bevacizumab	2 / 3	Unknown Status	2
DB00112	Bevacizumab	2 / 3	Withdrawn	1
DB01234	Dexamethasone	2 / 3	Active Not Recruiting	1
DB01234	Dexamethasone	2 / 3	Unknown Status	1
DB00869	Dorzolamide	2 / 3	Active Not Recruiting	1
DB00591	Fluocinolone acetonide	2 / 3	Completed	1
DB00591	Fluocinolone acetonide	2 / 3	Withdrawn	1
DB01270	Ranibizumab	2 / 3	Unknown Status	2
DB01270	Ranibizumab	2 / 3	Withdrawn	1
DB00373	Timolol	2 / 3	Active Not Recruiting	1
DB00620	Triamcinolone	2 / 3	Completed	4
DB08885	Aflibercept	3	Active Not Recruiting	3
DB08885	Aflibercept	3	Completed	13
DB08885	Aflibercept	3	Recruiting	1
DB08885	Aflibercept	3	Withdrawn	1
DB00112	Bevacizumab	3	Active Not Recruiting	1
DB00112	Bevacizumab	3	Completed	9
DB00112	Bevacizumab	3	Recruiting	1
DB00112	Bevacizumab	3	Unknown Status	3
DB14864	Brolucizumab	3	Completed	4
DB14864	Brolucizumab	3	Withdrawn	1
DB12460	Conbercept	3	Unknown Status	1
DB01234	Dexamethasone	3	Completed	4
DB15303	Faricimab	3	Active Not Recruiting	1
DB15303	Faricimab	3	Completed	3
DB08162	Fasudil	3	Completed	1
DB00591	Fluocinolone acetonide	3	Completed	3
DB00065	Infliximab	3	Terminated	1
DB06802	Nepafenac	3	Completed	1
DB04895	Pegaptanib	3	Completed	1
DB15212	Pemafibrate	3	Terminated	1
DB01270	Ranibizumab	3	Active Not Recruiting	1
DB01270	Ranibizumab	3	Completed	13
DB01270	Ranibizumab	3	Recruiting	1
DB01270	Ranibizumab	3	Unknown Status	1
DB11829	Ruboxistaurin	3	Completed	1
DB00620	Triamcinolone	3	Completed	8
DB00620	Triamcinolone	3	Unknown Status	2
DB08885	Aflibercept	4	Active Not Recruiting	1
DB08885	Aflibercept	4	Completed	11
DB08885	Aflibercept	4	Recruiting	5
DB08885	Aflibercept	4	Unknown Status	6
DB08885	Aflibercept	4	Withdrawn	1
DB00126	Ascorbic acid	4	Completed	1
DB00112	Bevacizumab	4	Completed	9
DB00112	Bevacizumab	4	Recruiting	1
DB00112	Bevacizumab	4	Terminated	1
DB00112	Bevacizumab	4	Unknown Status	1
DB00963	Bromfenac	4	Completed	2
DB06724	Calcium carbonate	4	Completed	1
DB11059	Carboxymethylcellulose	4	Unknown Status	1
DB00169	Cholecalciferol	4	Completed	1
DB00115	Cyanocobalamin	4	Completed	1
DB01234	Dexamethasone	4	Completed	8
DB01234	Dexamethasone	4	Recruiting	3
DB01234	Dexamethasone	4	Terminated	2
DB01234	Dexamethasone	4	Unknown Status	3
DB00586	Diclofenac	4	Unknown Status	1
DB01075	Diphenhydramine	4	Completed	1
DB15303	Faricimab	4	Not Yet Recruiting	2
DB15303	Faricimab	4	Recruiting	1
DB00591	Fluocinolone acetonide	4	Completed	2
DB00591	Fluocinolone acetonide	4	Recruiting	2
DB00591	Fluocinolone acetonide	4	Withdrawn	1
DB00158	Folic acid	4	Completed	1
DB01592	Iron	4	Completed	1
DB06802	Nepafenac	4	Completed	1
DB06802	Nepafenac	4	Unknown Status	1
DB02701	Nicotinamide	4	Completed	1
DB04895	Pegaptanib	4	Completed	3
DB06715	Potassium Iodide	4	Completed	1
DB15566	Prednisolone acetate	4	Terminated	1
DB00165	Pyridoxine	4	Completed	1
DB01270	Ranibizumab	4	Completed	8
DB01270	Ranibizumab	4	Recruiting	2
DB01270	Ranibizumab	4	Terminated	2
DB01270	Ranibizumab	4	Unknown Status	5
DB01270	Ranibizumab	4	Withdrawn	1
DB00140	Riboflavin	4	Completed	1
DB00152	Thiamine	4	Completed	1
DB00620	Triamcinolone	4	Completed	2
DB00163	Vitamin E	4	Completed	1
DB09321	Zinc oxide	4	Completed	1
DB08885	Aflibercept	Not Available	Active Not Recruiting	1
DB08885	Aflibercept	Not Available	Completed	8
DB08885	Aflibercept	Not Available	Not Yet Recruiting	1
DB08885	Aflibercept	Not Available	Recruiting	3
DB08885	Aflibercept	Not Available	Unknown Status	2
DB00009	Alteplase	Not Available	Terminated	1
DB00126	Ascorbic acid	Not Available	Unknown Status	1
DB00112	Bevacizumab	Not Available	Completed	5
DB00112	Bevacizumab	Not Available	Recruiting	1
DB00112	Bevacizumab	Not Available	Terminated	1
DB00112	Bevacizumab	Not Available	Withdrawn	1
DB12460	Conbercept	Not Available	Recruiting	1
DB00151	Cysteine	Not Available	Unknown Status	1
DB01234	Dexamethasone	Not Available	Completed	7
DB01234	Dexamethasone	Not Available	Not Yet Recruiting	1
DB01234	Dexamethasone	Not Available	Terminated	1
DB01234	Dexamethasone	Not Available	Withdrawn	1
DB00869	Dorzolamide	Not Available	Unknown Status	1
DB15303	Faricimab	Not Available	Recruiting	1
DB00591	Fluocinolone acetonide	Not Available	Unknown Status	1
DB11735	Galactose	Not Available	Terminated	1
DB04077	Glycerin	Not Available	Completed	1
DB08818	Hyaluronic acid	Not Available	Unknown Status	1
DB04335	Inosine	Not Available	Unknown Status	1
DB00465	Ketorolac	Not Available	Completed	1
DB00281	Lidocaine	Not Available	Completed	1
DB14596	Loteprednol etabonate	Not Available	Completed	1
DB00563	Methotrexate	Not Available	Terminated	1
DB01017	Minocycline	Not Available	Unknown Status	1
DB02701	Nicotinamide	Not Available	Unknown Status	1
DB04895	Pegaptanib	Not Available	Available	1
DB04895	Pegaptanib	Not Available	Completed	1
DB06812	Povidone-iodine	Not Available	Unknown Status	1
DB00807	Proparacaine	Not Available	Completed	2
DB01270	Ranibizumab	Not Available	Active Not Recruiting	1
DB01270	Ranibizumab	Not Available	Completed	9
DB01270	Ranibizumab	Not Available	Recruiting	3
DB09085	Tetracaine	Not Available	Completed	1
DB11251	Tocopherol	Not Available	Unknown Status	1
DB12647	Tocotrienol	Not Available	Unknown Status	1
DB00620	Triamcinolone	Not Available	Completed	2
DB00620	Triamcinolone	Not Available	Recruiting	1
DB00809	Tropicamide	Not Available	Recruiting	1
DB09270	Ubidecarenone	Not Available	Unknown Status	1